Search Results - "Buzzai, Monica"

AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint by Jones, Russell G., Plas, David R., Kubek, Sara, Buzzai, Monica, Mu, James, Xu, Yang, Birnbaum, Morris J., Thompson, Craig B.

“…Replicative cell division is an energetically demanding process that can be executed only if cells have sufficient metabolic resources to support a doubling of…”
Get full text

Akt stimulates aerobic glycolysis in cancer cells by ELSTROM, Rebecca L, BAUER, Daniel E, THOMPSON, Craig B, BUZZAI, Monica, KARNAUSKAS, Robyn, HARRIS, Marian H, PLAS, David R, HONGMING ZHUANG, CINALLI, Ryan M, ALAVI, Abass, RUDIN, Charles M

“…Cancer cells frequently display high rates of aerobic glycolysis in comparison to their nontransformed counterparts, although the molecular basis of this…”
Get full text

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation by BUZZAI, Monica, BAUER, Daniel E, JONES, Russell G, DEBERARDINIS, Ralph J, HATZIVASSILIOU, Georgia, ELSTROM, Rebecca L, THOMPSON, Craig B

“…Activation of the oncogenic kinase Akt stimulates glucose uptake and metabolism in cancer cells and renders these cells susceptible to death in response to…”
Get full text

Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth by Fei, Peiwen, Wang, Wenge, Kim, Seok-hyun, Wang, Shulin, Burns, Timothy F., Sax, Joanna K., Buzzai, Monica, Dicker, David T., McKenna, W.Gillies, Bernhard, Eric J., El-Deiry, Wafik S.

“…p53-dependent apoptosis is a major determinant of its tumor suppressor activity and can be triggered by hypoxia. No p53 target is known to be induced by p53 or…”
Get full text

Reduced expression of α5β1 integrin prevents spreading-dependent cell proliferation by Davey, Gabriela, Buzzai, Monica, Assoian, Richard K.

“…ABSTRACT Cell adhesion to substratum results in the initiation of integrin signaling and an integrin-dependent organization of the cytoskeleton (cell…”
Get full text

Distinct Effects of Mitogens and the Actin Cytoskeleton on CREB and Pocket Protein Phosphorylation Control the Extent and Timing of Cyclin A Promoter Activity by Bottazzi, Maria Elena, Buzzai, Monica, Zhu, Xiaoyun, Desdouets, Chantal, Bréchot, Christian, Assoian, Richard K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth by BUZZAI, Monica, JONES, Russell G, AMARAVADI, Ravi K, LUM, Julian J, DEBERARDINIS, Ralph J, FANGPING ZHAO, VIOLLET, Benoit, THOMPSON, Craig B

“…The effect of the antidiabetic drug metformin on tumor growth was investigated using the paired isogenic colon cancer cell lines HCT116 p53(+/+) and HCT116…”
Get full text

New molecular concepts and targets in acute myeloid leukemia by Buzzai, Monica, Licht, Jonathan D

“…PURPOSE OF REVIEWMost patients with acute myeloid leukemia treated with chemotherapy relapse. It is increasingly recognized that the cause of chemoresistance…”
Get full text

Transcriptional Profiling of Polycythemia Vera Identifies Gene Expression Patterns Both Dependent and Independent from the Action of JAK2V617F by BERKOFSKY-FESSLER, Windy, BUZZAI, Monica, WEIJIA ZHANG, LEVINE, Ross, GARY GILLILAND, D, CALOGERO, Raffaele, LICHT, Jonathan D, KIM, Marianne K-H, FRUCHTMAN, Steven, NAJFELD, Vesna, MIN, Dong-Joon, COSTA, Fabricio F, BISCHOF, Jared M, SOARES, Marcelo B, MCCONNELL, Melanie Jane

“…To understand the changes in gene expression in polycythemia vera (PV) progenitor cells and their relationship to JAK2V617F. Messenger RNA isolated from…”
Get full text

Specific MicroRNA Deregulated in Myleoproliferative Neoplasm Are Regulated by JAK2V617F and May Contribute to Aberrant Hematopoiesis by Lin, Xiaoqing, Buzzai, Monica, Carroll, Martin, Hexner, Elizabeth, Costa, Fabricio F, Soares, Marcelo B., Licht, Jonathan D.

“…Abstract 965 The myeloproliferative neoplasms (MPN), PV, ET and IMF, harbor the same gain-of-function mutation JAK2V617F at a high frequency (∼100%, 70% and…”
Get full text

NFIB: A Gene Consistently Upregulated in MPD and Frequently Co-Amplified with JAK2V617F Augments Growth of Erythropoietin Dependent Cells by Lin, Xiaoqing, Buzzai, Monica, Levine, Ross L, Berkofsky-Fessler, Windy, Zhang, Weijia, Ebert, Benjamin L., Gilliland, D. Gary, Licht, Jonathan D.

“…Myeloproliferative disorders (MPDs) are characterized by abnormal proliferation of one or more myeloid lineages. Among MPDs, three distinct yet related…”
Get full text

Integrative Analysis of Genomic Aberration and Gene Expression Suggests That MPD with Loss of Heterozygosity or Gain of Chromosome 9 Represents a Distinct Entity by Zhang, Weijia, Ebert, Benjamin L., Berkofsky-Fessler, Windy, Buzzai, Monica, Sun, Yezhou, Xi, Caixia, Levine, Ross L, Gilliland, D. Gary, Licht, Jonathan D.

“…Polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF) can all be associated with the JAK2V617F gain of function mutation…”
Get full text

The role of AMPK in modulating the metabolism and survival of cancer cells by Buzzai, Monica

“…Cells need a constant supply of energy to maintain bioenergetic and survival. Upregulation of aerobic glycolysis, a phenomenon known as the Warburg effect, is…”
Get full text

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid -oxidation by Buzzai, Monica, Bauer, Daniel E, Jones, Russell G, DeBerardinis, Ralph J, Hatzivassiliou, Georgia, Elstrom, Rebecca L, Thompson, Craig B

“…Activation of the oncogenic kinase Akt stimulates glucose uptake and metabolism in cancer cells and renders these cells susceptible to death in response to…”
Get full text

An AMPK-p53 Connection Mediates a Checkpoint to Inhibit Cell Proliferation in Response to Low Glucose

“…Researchers at the University of Pennsylvania School of Medicine have identified in normal cells that a common metabolic enzyme, which acts as a rheostat of…”
Get full text

The role of AMPK in modulating the metabolism and survival of cancer cells by Buzzai, Monica

“…Cells need a constant supply of energy to maintain bioenergetic and survival. Upregulation of aerobic glycolysis, a phenomenon known as the Warburg effect, is…”
Get full text

cDNA Characterization and Chromosome Mapping of the Human GAS2 Gene by Collavin, Licio, Buzzai, Monica, Saccone, Salvatore, Bernard, Loris, Federico, Concetta, DellaValle, Giuliano, Brancolini, Claudio, Schneider, Claudio

“…Murine Gas2 is a microfilament-associated protein whose expression is increased at growth arrest in mammalian cells. During apoptosis, Gas2 is specifically…”
Get full text