Search Results - "Buzon, Maria J"

Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations by Grau-Expósito, Judith, Luque-Ballesteros, Laura, Navarro, Jordi, Curran, Adrian, Burgos, Joaquin, Ribera, Esteban, Torrella, Ariadna, Planas, Bibiana, Badía, Rosa, Martin-Castillo, Mario, Fernández-Sojo, Jesús, Genescà, Meritxell, Falcó, Vicenç, Buzon, Maria J

“…Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are ineffective at decreasing the size of the latent reservoir in…”
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Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells by Grau-Expósito, Judith, Perea, David, Suppi, Marina, Massana, Núria, Vergara, Ander, Soler, Maria José, Trinite, Benjamin, Blanco, Julià, García-Pérez, Javier, Alcamí, José, Serrano-Mollar, Anna, Rosado, Joel, Falcó, Vicenç, Genescà, Meritxell, Buzon, Maria J

“…The development of physiological models that reproduce SARS-CoV-2 infection in primary human cells will be instrumental to identify host-pathogen interactions…”
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Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa by Cantero-Pérez, Jon, Grau-Expósito, Judith, Serra-Peinado, Carla, Rosero, Daniela A., Luque-Ballesteros, Laura, Astorga-Gamaza, Antonio, Castellví, Josep, Sanhueza, Tamara, Tapia, Gustavo, Lloveras, Belen, Fernández, Marco A., Prado, Julia G., Solé-Sedeno, Josep M., Tarrats, Antoni, Lecumberri, Carla, Mañalich-Barrachina, Laura, Centeno-Mediavilla, Cristina, Falcó, Vicenç, Buzon, Maria J., Genescà, Meritxell

“…HIV viral reservoirs are established very early during infection. Resident memory T cells (T RM ) are present in tissues such as the lower female genital…”
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A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4 + T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients by Grau-Expósito, Judith, Serra-Peinado, Carla, Miguel, Lucia, Navarro, Jordi, Curran, Adrià, Burgos, Joaquin, Ocaña, Imma, Ribera, Esteban, Torrella, Ariadna, Planas, Bibiana, Badía, Rosa, Castellví, Josep, Falcó, Vicenç, Crespo, Manuel, Buzon, Maria J

“…Cells that actively transcribe HIV-1 have been defined as the "active viral reservoir" in HIV-infected individuals. However, important technical limitations…”
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A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes by Jones, R Brad, Mueller, Stefanie, O'Connor, Rachel, Rimpel, Katherine, Sloan, Derek D, Karel, Dan, Wong, Hing C, Jeng, Emily K, Thomas, Allison S, Whitney, James B, Lim, So-Yon, Kovacs, Colin, Benko, Erika, Karandish, Sara, Huang, Szu-Han, Buzon, Maria J, Lichterfeld, Mathias, Irrinki, Alivelu, Murry, Jeffrey P, Tsai, Angela, Yu, Helen, Geleziunas, Romas, Trocha, Alicja, Ostrowski, Mario A, Irvine, Darrell J, Walker, Bruce D

“…Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little…”
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Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication by Kladnik, Jerneja, Dolinar, Ana, Kljun, Jakob, Perea, David, Grau-Expósito, Judith, Genescà, Meritxell, Novinec, Marko, Buzon, Maria J., Turel, Iztok

“…Zinc pyrithione (1a), together with its analogues 1b-h and ruthenium pyrithione complex 2a, were synthesised and evaluated for the stability in biologically…”
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Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab by Serra-Peinado, Carla, Grau-Expósito, Judith, Luque-Ballesteros, Laura, Astorga-Gamaza, Antonio, Navarro, Jordi, Gallego-Rodriguez, Jenny, Martin, Mario, Curran, Adrià, Burgos, Joaquin, Ribera, Esteban, Raventós, Berta, Willekens, Rein, Torrella, Ariadna, Planas, Bibiana, Badía, Rosa, Garcia, Felipe, Castellví, Josep, Genescà, Meritxell, Falcó, Vicenç, Buzon, Maria J.

“…The identification of exclusive markers to target HIV-reservoir cells will represent a significant advance in the search for therapies to cure HIV. Here, we…”
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Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response by Astorga-Gamaza, Antonio, Grau-Expósito, Judith, Burgos, Joaquín, Navarro, Jordi, Curran, Adrià, Planas, Bibiana, Suanzes, Paula, Falcó, Vicenç, Genescà, Meritxell, Buzon, Maria

“…HIV establishes a persistent infection in heterogeneous cell reservoirs, which can be maintained by different mechanisms including cellular proliferation, and…”
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A Cell-Intrinsic Inhibitor of HIV-1 Reverse Transcription in CD4+ T Cells from Elite Controllers by Leng, Jin, Ho, Hsin-Pin, Buzon, Maria J., Pereyra, Florencia, Walker, Bruce D., Yu, Xu G., Chang, Emmanuel J., Lichterfeld, Mathias

“…HIV-1 reverse transcription represents the predominant target for pharmacological inhibition of viral replication, but cell-intrinsic mechanisms that can block…”
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Inhibition of HIV-1 Integration in Ex Vivo-Infected CD4 T Cells from Elite Controllers by BUZON, Maria J, SEISS, Katherine, WEISS, Robert, BRASS, Abraham L, ROSENBERG, Eric S, PEREYRA, Florencia, YU, Xu G, LICHTERFELD, Mathias

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Transcriptional Profiling of CD4 T Cells Identifies Distinct Subgroups of HIV-1 Elite Controllers by VIGNEAULT, Francois, WOODS, Matthew, TELENTI, Amalio, YU, Xu G, LICHTERFELD, Mathias, BUZON, Maria J, CHUN LI, PEREYRA, Florencia, CROSBY, Seth D, RYCHERT, Jennifer, CHURCH, George, MARTINEZ-PICADO, Javier, ROSENBERG, Eric S

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Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells by Kobayashi-Ishihara, Mie, Frazão Smutná, Katarína, Alonso, Florencia E., Argilaguet, Jordi, Esteve-Codina, Anna, Geiger, Kerstin, Genescà, Meritxell, Grau-Expósito, Judith, Duran-Castells, Clara, Rogenmoser, Selina, Böttcher, René, Jungfleisch, Jennifer, Oliva, Baldomero, Martinez, Javier P., Li, Manqing, David, Michael, Yamagishi, Makoto, Ruiz-Riol, Marta, Brander, Christian, Tsunetsugu-Yokota, Yasuko, Buzon, Maria J., Díez, Juana, Meyerhans, Andreas

“…Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are…”
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The active human immunodeficiency virus reservoir during antiretroviral therapy: emerging players in viral persistence by Astorga-Gamaza, Antonio, Buzon, Maria J.

“…To discuss the role of CD4+ T cells with active Human immunodeficiency virus (HIV), meaning infected cells with transcriptional and/or translational viral…”
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HIV-1 persistence in CD4+ T cells with stem cell–like properties by Buzon, Maria J, Sun, Hong, Li, Chun, Shaw, Amy, Seiss, Katherine, Ouyang, Zhengyu, Martin-Gayo, Enrique, Leng, Jin, Henrich, Timothy J, Li, Jonathan Z, Pereyra, Florencia, Zurakowski, Ryan, Walker, Bruce D, Rosenberg, Eric S, Yu, Xu G, Lichterfeld, Mathias

“…Understanding how and where HIV-1 infection persists in the body is crucial for efforts to eradicate the viral reservoir. Now Mathias Lichterfeld and his…”
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Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells by Buzon, Maria J, Martin-Gayo, Enrique, Pereyra, Florencia, Ouyang, Zhengyu, Sun, Hong, Li, Jonathan Z, Piovoso, Michael, Shaw, Amy, Dalmau, Judith, Zangger, Nadine, Martinez-Picado, Javier, Zurakowski, Ryan, Yu, Xu G, Telenti, Amalio, Walker, Bruce D, Rosenberg, Eric S, Lichterfeld, Mathias

“…Initiation of antiretroviral therapy during the earliest stages of HIV-1 infection may limit the seeding of a long-lasting viral reservoir, but long-term…”
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HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects by J Buzón, Maria, Massanella, Marta, Llibre, Josep M, Esteve, Anna, Dahl, Viktor, Puertas, Maria C, Gatell, Josep M, Domingo, Pere, Paredes, Roger, Sharkey, Mark, Palmer, Sarah, Stevenson, Mario, Clotet, Bonaventura, Blanco, Julià, Martinez-Picado, Javier

“…Despite highly active antiretroviral therapy, active replication persists and drives immune activation in some individuals with HIV. This activation is higher…”
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Recommendations for measuring HIV reservoir size in cure-directed clinical trials by Abdel-Mohsen, Mohamed, Richman, Douglas, Siliciano, Robert F., Nussenzweig, Michel C., Howell, Bonnie J., Martinez-Picado, Javier, Chomont, Nicolas, Bar, Katharine J., Yu, Xu G., Lichterfeld, Mathias, Alcami, Jose, Hazuda, Daria, Bushman, Frederic, Siliciano, Janet D., Betts, Michael R., Spivak, Adam M., Planelles, Vicente, Hahn, Beatrice H., Smith, Davey M., Ho, Ya-Chi, Buzon, Maria J., Gaebler, Christian, Paiardini, Mirko, Li, Qingsheng, Estes, Jacob D., Hope, Thomas J., Kostman, Jay, Mounzer, Karam, Caskey, Marina, Fox, Lawrence, Frank, Ian, Riley, James L., Tebas, Pablo, Montaner, Luis J.

“…Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or to achieve virologic control in the absence of antiretroviral…”
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Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers by PEREYRA, Florencia, LO, Janet, ABBARA, Suhny, GRINSPOON, Steven K, TRIANT, Virginia A, WEI, Jeffrey, BUZON, Maria J, FITCH, Kathleen V, HWANG, Janice, CAMPBELL, Jennifer H, BURDO, Tricia H, WILLIAMS, Kenneth C

“…HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary…”
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Hepatitis C Therapy With Interferon-α and Ribavirin Reduces CD4 T-Cell–Associated HIV-1 DNA in HIV-1/Hepatitis C Virus–Coinfected Patients by Sun, Hong, Buzon, Maria J., Shaw, Amy, Berg, Randi Karteebahn, Yu, Xu G., Ferrando-Martinez, Sara, Leal, Manuel, Ruiz-Mateos, Ezequiel, Lichterfeld, Mathias

“…Combined treatment with interferon alpha (IFN-α) and ribavirin (RBV) can effectively cure HCV infection in a significant proportion of patients, but effects of…”
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Antibody cooperative adsorption onto AuNPs and its exploitation to force natural killer cells to kill HIV-infected T cells by Astorga-Gamaza, Antonio, Vitali, Michele, Borrajo, Mireya L., Suárez-López, Rosa, Jaime, Carlos, Bastus, Neus, Serra-Peinado, Carla, Luque-Ballesteros, Laura, Blanch-Lombarte, Oscar, Prado, Julia G., Lorente, Juan, Pumarola, Felix, Pellicer, Marc, Falcó, Vicenç, Genescà, Meritxell, Puntes, Víctor, Buzon, Maria J.

“…•We generate a new nanotool consisting of bispecific nanoparticles with cooperatively-adsorbed antibodies at their surface.•No modification of antibodies or…”
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