Search Results - "Buzková, Helena"

Lipid-lowering effect of fluvastatin in relation to cytochrome P450 2C9 variant alleles frequently distributed in the Czech population by Buzková, Helena, Pechandová, Kristina, Danzig, Vilém, Vareka, Tomá, Perlik, Frantisek, Zak, Ales, Slanar, Ondrej

“…CYP2C9*3 allele has been reported to correlate with increased plasma concentration of fluvastatin active form in healthy volunteers. We analyzed the…”
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Frequency of single nucleotide polymorphisms of CYP2D6 in the Czech population by Buzková, Helena, Pechandová, Kristina, Slanař, Ondřej, Perlík, František

“…CYP2D6 is a member of cytochrome P450 enzymes that metabolise over 25% of commonly used drugs. Genetic polymorphisms can cause insufficient drug efficacy at…”
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Polymorphisms of the TPMT Gene in the Czech Healthy Population and Patients with Inflammatory Bowel Disease by Slanař, Ondřej, Bortlík, Martin, Buzková, Helena, Donoval, Robert, Pechandová, Kristina, Šebesta, Ivan, Lukáš, Milan, Perlík, František

“…Genetic variation in thiopurine S-methyltransferase (TPMT) is a major factors for wide variation in the metabolism and safety of thiopurine drugs. We…”
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Genetic polymorphisms of CYP2C8 in the Czech Republic by Pechandova, Kristina, Buzkova, Helena, Matouskova, Olga, Perlik, Frantisek, Slanar, Ondrej

“…CYP2C8 represents 7% of the hepatic cytochrome system and metabolizes around 5% of drugs in phase I processes. It also plays a significant role in metabolism…”
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