Search Results - "Buzder, Timea"
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Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma
Published in Blood (29-09-2016)“…To elucidate the mechanisms underlying relapse from chemotherapy in multiple myeloma, we performed a longitudinal study of 33 patients entered into Total…”
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Extensive Regional Intra-Clonal Heterogeneity in Multiple Myeloma - Implications for Diagnostics, Risk Stratification and Targeted Treatment
Published in Blood (02-12-2016)“…INTRODUCTION In multiple myeloma (MM) samples for diagnostics, prognostication and response evaluation are most commonly obtained from the patients' posterior…”
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Induction of renal endonuclease G by cisplatin is reduced in DNase I-deficient mice
Published in Journal of the American Society of Nephrology (01-09-2007)“…Nephrotoxicity from the chemotherapeutic drug cisplatin is associated with DNA fragmentation and cell death. We have recently demonstrated that DNase I…”
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Uptake of foreign nucleic acids in kidney tubular epithelial cells deficient in proapoptotic endonucleases
Published in DNA and cell biology (01-09-2009)“…Degradation of DNA during gene delivery is an obstacle for gene transfer and for gene therapy. DNases play a major role in degrading foreign DNA. However,…”
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523. Deoxyribonuclease I and Endonuclease G Are Host Defense Enzymes Responsible for Inactivation of Foreign DNA in Kidney Tubular Epithelial Cells
Published in Molecular therapy (01-05-2006)“…Gene delivery to kidney cells is essential for the development of gene therapy of nephropathy. Maintaining DNA stability is crucial for successful gene…”
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