Search Results - "Buynak, John D."

C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation by Stewart, Nichole K, Toth, Marta, Alqurafi, Maha A, Chai, Weirui, Nguyen, Thu Q, Quan, Pojun, Lee, Mijoon, Buynak, John D, Smith, Clyde A, Vakulenko, Sergei B

“…Acinetobacter baumannii has become a major nosocomial pathogen, as it is often multidrug-resistant, which results in infections characterized by high mortality…”
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Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226 by Ke, Wei, Bethel, Christopher R, Papp-Wallace, Krisztina M, Pagadala, Sundar Ram Reddy, Nottingham, Micheal, Fernandez, Daniel, Buynak, John D, Bonomo, Robert A, van den Akker, Focco

“…Class A carbapenemases are a major threat to the potency of carbapenem antibiotics. A widespread carbapenemase, KPC-2, is not easily inhibited by β-lactamase…”
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Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3 by Papp-Wallace, Krisztina M, Senkfor, Baui, Gatta, Julian, Chai, Weirui, Taracila, Magdalena A, Shanmugasundaram, Veerabahu, Han, Seungil, Zaniewski, Richard P, Lacey, Brian M, Tomaras, Andrew P, Skalweit, Marion J, Harris, Michael E, Rice, Louis B, Buynak, John D, Bonomo, Robert A

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Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies by Zhu, Dunming, Yang, Yan, Buynak, John D, Hua, Ling

“…In our effort to search for effective carbonyl reductases, the activity and enantioselectivity of a carbonyl reductase from Sporobolomyces salmonicolor have…”
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Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against Acinetobacter spp by Lasarte-Monterrubio, Cristina, Vázquez-Ucha, Juan C, Maneiro, Maria, Arca-Suárez, Jorge, Alonso, Isaac, Guijarro-Sánchez, Paula, Buynak, John D, Bou, Germán, González-Bello, Concepción, Beceiro, Alejandro

“…Treatment of infections caused by spp., particularly , is a major clinical problem due to its high rates of antibiotic resistance. New strategies must be…”
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Triethysilyl enol ethers in the synthesis of carbapenem precursors by Nguyen, Thu Q., Chai, Weirui, Gu, Jane, Cook, Katie, Kim, Eugene, Goetz, Sam, Farni, Zach, Chepuru, Monica, Cox, Melina, Nguyen, Pauline, Raja, Hashim, Magistrado, Patrick, Michael, Faith, Oelschlaeger, Peter, Buynak, John D.

“…[Display omitted] A diastereoselective process for the formation of intermediates suitable for the preparation of C1 substituted carbapenems was developed. The…”
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Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition by Rodkey, Elizabeth A, Winkler, Marisa L, Bethel, Christopher R, Pagadala, Sundar Ram Reddy, Buynak, John D, Bonomo, Robert A, van den Akker, Focco

“…β-Lactamases are the major reason β-lactam resistance is seen in Gram-negative bacteria. To combat this resistance mechanism, β-lactamase inhibitors are…”
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Cutting and Stitching: The Cross-Linking of Peptidoglycan in the Assembly of the Bacterial Cell Wall by Buynak, John D

“…The machinery responsible for bacterial cell wall synthesis has proven to be an invaluable antibiotic target. Nearly 80 years after the discovery of…”
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Penicillin Sulfone Inhibitors of Class D β-Lactamases by DRAWZ, Sarah M, BETHEL, Christopher R, BONOMO, Robert A, DOPPALAPUDI, Venkata R, SHERI, Anjaneyulu, SUNDAR RAM REDDY PAGADALA, HUJER, Andrea M, SKALWEIT, Marion J, ANDERSON, Vernon E, CHEN, Shu G, BUYNAK, John D

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Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation by Ke, Wei, Pattanaik, Priyaranjan, Bethel, Christopher R, Sheri, Anjaneyulu, Buynak, John D, Bonomo, Robert A, van den Akker, Focco

“…Bacterial β-lactamase enzymes are in large part responsible for the decreased ability of β-lactam antibiotics to combat infections. The inability to overcome…”
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Ligand-Dependent Disorder of the Ω Loop Observed in Extended-Spectrum SHV-Type β-Lactamase by SAMPSON, Jared M, WEI KE, BETHEL, Christopher R, PAGADALA, S. R. R, NOTTINGHAM, Michael D, BONOMO, Robert A, BUYNAK, John D, VAN DEN AKKER, Focco

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β-Lactamase inhibitors: a review of the patent literature (2010 - 2013) by Buynak, John D

“…New β-lactamases with ever-broadening substrate specificity are rapidly disseminating globally, thereby threatening the efficacy of our best β-lactam…”
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Virtual Screening and Experimental Testing of B1 Metallo-β-lactamase Inhibitors by Kang, Joon S, Zhang, Antonia L, Faheem, Mohammad, Zhang, Charles J, Ai, Ni, Buynak, John D, Welsh, William J, Oelschlaeger, Peter

“…The global rise of metallo-β-lactamases (MBLs) is problematic due to their ability to inactivate most β-lactam antibiotics. MBL inhibitors that could be…”
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Evaluation of β-Lactamase Inhibitors in Disk Tests for Detection of Plasmid-Mediated AmpC β-Lactamases in Well-Characterized Clinical Strains of Klebsiella spp by BLACK, Jennifer A, THOMSON, Kenneth S, BUYNAK, John D, PITOUT, Johann D. D

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Understanding the longevity of the β-lactam antibiotics and of antibiotic/β-lactamase inhibitor combinations by Buynak, John D.

“…Microbial resistance necessitates the search for new targets and new antibiotics. However, it is likely that resistance problems will eventually threaten these…”
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Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii by Vázquez-Ucha, Juan Carlos, Martínez-Guitián, Marta, Maneiro, María, Conde-Pérez, Kelly, Álvarez-Fraga, Laura, Torrens, Gabriel, Oliver, Antonio, Buynak, John D, Bonomo, Robert A, Bou, Germán, González-Bello, Concepción, Poza, Margarita, Beceiro, Alejandro

“…The carbapenem-hydrolyzing class D β-lactamases (CHDLs) are the main mechanism of carbapenem resistance in CHDLs are not effectively inactivated by clinically…”
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An efficient and general urazole synthesis by Chai, Weirui, Chang, Yuan, Buynak, John D.

“…A general two-step scheme for the synthesis of N4 substituted urazoles (i.e., 1,2,4-triazolin-3,5-diones) is described. The first step involves the reaction of…”
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The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases by Smith, Clyde A., Stewart, Nichole K., Toth, Marta, Quan, Pojun, Buynak, John D., Vakulenko, Sergei B.

“…The wide spread of carbapenem-hydrolyzing β-lactamases in Gram-negative bacteria has diminished the utility of the last-resort carbapenem antibiotics,…”
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LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48 by Vallejo, Juan A, Martínez-Guitián, Marta, Vázquez-Ucha, Juan C, González-Bello, Concepción, Poza, Margarita, Buynak, John D, Bethel, Christopher R, Bonomo, Robert A, Bou, German, Beceiro, Alejandro

“…Carbapenemases are the most important mechanism responsible for carbapenem resistance in Enterobacteriaceae. Among carbapenemases, OXA-48 presents unique…”
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Structure-Activity Relationships of Different β-Lactam Antibiotics against a Soluble Form of Enterococcus faecium PBP5, a Type II Bacterial Transpeptidase by HUJER, Andrea M, KANIA, Malgosia, GERKEN, Thomas, ANDERSON, Vernon E, BUYNAK, John D, XIAOXIA GE, CASPERS, Patrick, PAGE, Malcolm G. P, RICE, Louis B, BONOMO, Robert A

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