Search Results - "Buus, Søren"

Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification by Andreatta, Massimo, Karosiene, Edita, Rasmussen, Michael, Stryhn, Anette, Buus, Søren, Nielsen, Morten

“…A key event in the generation of a cellular response against malicious organisms through the endocytic pathway is binding of peptidic antigens by major…”
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Improved methods for predicting peptide binding affinity to MHC class II molecules by Jensen, Kamilla Kjærgaard, Andreatta, Massimo, Marcatili, Paolo, Buus, Søren, Greenbaum, Jason A., Yan, Zhen, Sette, Alessandro, Peters, Bjoern, Nielsen, Morten

“…Summary Major histocompatibility complex class II (MHC‐II) molecules are expressed on the surface of professional antigen‐presenting cells where they display…”
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Pan-Specific Prediction of Peptide-MHC Class I Complex Stability, a Correlate of T Cell Immunogenicity by Rasmussen, Michael, Fenoy, Emilio, Harndahl, Mikkel, Kristensen, Anne Bregnballe, Nielsen, Ida Kallehauge, Nielsen, Morten, Buus, Søren

“…Binding of peptides to MHC class I (MHC-I) molecules is the most selective event in the processing and presentation of Ags to CTL, and insights into the…”
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NetMHCIIpan-3.0, a common pan-specific MHC class II prediction method including all three human MHC class II isotypes, HLA-DR, HLA-DP and HLA-DQ by Karosiene, Edita, Rasmussen, Michael, Blicher, Thomas, Lund, Ole, Buus, Søren, Nielsen, Morten

“…Major histocompatibility complex class II (MHCII) molecules play an important role in cell-mediated immunity. They present specific peptides derived from…”
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NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11 by Lundegaard, Claus, Lamberth, Kasper, Harndahl, Mikkel, Buus, Søren, Lund, Ole, Nielsen, Morten

“…NetMHC-3.0 is trained on a large number of quantitative peptide data using both affinity data from the Immune Epitope Database and Analysis Resource (IEDB) and…”
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NNAlign_MA; MHC Peptidome Deconvolution for Accurate MHC Binding Motif Characterization and Improved T-cell Epitope Predictions by Alvarez, Bruno, Reynisson, Birkir, Barra, Carolina, Buus, Søren, Ternette, Nicola, Connelley, Tim, Andreatta, Massimo, Nielsen, Morten

“…The set of peptides presented on a cell's surface by MHC molecules is poly-specific (it contains multiple sequence motifs matching the quantity of MHC…”
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MHC Class II epitope predictive algorithms by Nielsen, Morten, Lund, Ole, Buus, Søren, Lundegaard, Claus

“…Major histocompatibility complex class II (MHC-II) molecules sample peptides from the extracellular space, allowing the immune system to detect the presence of…”
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Peptide‐MHC class I stability is a better predictor than peptide affinity of CTL immunogenicity by Harndahl, Mikkel, Rasmussen, Michael, Roder, Gustav, Dalgaard Pedersen, Ida, Sørensen, Mikael, Nielsen, Morten, Buus, Søren

“…Efficient presentation of peptide‐MHC class I (pMHC‐I) complexes to immune T cells should benefit from a stable peptide‐MHC‐I interaction. However, it has been…”
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NetMHCpan, a method for MHC class I binding prediction beyond humans by Hoof, Ilka, Peters, Bjoern, Sidney, John, Pedersen, Lasse Eggers, Sette, Alessandro, Lund, Ole, Buus, Søren, Nielsen, Morten

“…Binding of peptides to major histocompatibility complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular…”
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Footprints of antigen processing boost MHC class II natural ligand predictions by Barra, Carolina, Alvarez, Bruno, Paul, Sinu, Sette, Alessandro, Peters, Bjoern, Andreatta, Massimo, Buus, Søren, Nielsen, Morten

“…Major histocompatibility complex class II (MHC-II) molecules present peptide fragments to T cells for immune recognition. Current predictors for peptide to…”
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MHCcluster, a method for functional clustering of MHC molecules by Thomsen, Martin, Lundegaard, Claus, Buus, Søren, Lund, Ole, Nielsen, Morten

“…The identification of peptides binding to major histocompatibility complexes (MHC) is a critical step in the understanding of T cell immune responses. The…”
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Immunoinformatics: Predicting Peptide-MHC Binding by Nielsen, Morten, Andreatta, Massimo, Peters, Bjoern, Buus, Søren

“…Immunoinformatics is a discipline that applies methods of computer science to study and model the immune system. A fundamental question addressed by…”
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High-resolution Mapping of Linear Antibody Epitopes Using Ultrahigh-density Peptide Microarrays by Buus, Søren, Rockberg, Johan, Forsström, Björn, Nilsson, Peter, Uhlen, Mathias, Schafer-Nielsen, Claus

“…Antibodies empower numerous important scientific, clinical, diagnostic, and industrial applications. Ideally, the epitope(s) targeted by an antibody should be…”
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Major histocompatibility complex class I binding predictions as a tool in epitope discovery by Lundegaard, Claus, Lund, Ole, Buus, Søren, Nielsen, Morten

“…Over the last decade, in silico models of the major histocompatibility complex (MHC) class I pathway have developed significantly. Before, peptide binding…”
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NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and -B locus protein of known sequence by Nielsen, Morten, Lundegaard, Claus, Blicher, Thomas, Lamberth, Kasper, Harndahl, Mikkel, Justesen, Sune, Røder, Gustav, Peters, Bjoern, Sette, Alessandro, Lund, Ole, Buus, Søren

“…Binding of peptides to Major Histocompatibility Complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular…”
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Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding by Chappell, Paul, Meziane, El Kahina, Harrison, Michael, Magiera, Łukasz, Hermann, Clemens, Mears, Laura, Wrobel, Antony G, Durant, Charlotte, Nielsen, Lise Lotte, Buus, Søren, Ternette, Nicola, Mwangi, William, Butter, Colin, Nair, Venugopal, Ahyee, Trudy, Duggleby, Richard, Madrigal, Alejandro, Roversi, Pietro, Lea, Susan M, Kaufman, Jim

“…Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of…”
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Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpan by Nielsen, Morten, Lundegaard, Claus, Blicher, Thomas, Peters, Bjoern, Sette, Alessandro, Justesen, Sune, Buus, Søren, Lund, Ole

“…CD4 positive T helper cells control many aspects of specific immunity. These cells are specific for peptides derived from protein antigens and presented by…”
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Dataset size and composition impact the reliability of performance benchmarks for peptide-MHC binding predictions by Kim, Yohan, Sidney, John, Buus, Søren, Sette, Alessandro, Nielsen, Morten, Peters, Bjoern

“…It is important to accurately determine the performance of peptide:MHC binding predictions, as this enables users to compare and choose between different…”
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T Cell Responses Induced by Attenuated Flavivirus Vaccination Are Specific and Show Limited Cross-Reactivity with Other Flavivirus Species by Grifoni, Alba, Voic, Hannah, Dhanda, Sandeep Kumar, Kidd, Conner K, Brien, James D, Buus, Søren, Stryhn, Anette, Durbin, Anna P, Whitehead, Stephen, Diehl, Sean A, De Silva, Aruna D, Balmaseda, Angel, Harris, Eva, Weiskopf, Daniela, Sette, Alessandro

“…Members of the flavivirus genus share a high level of sequence similarity and often circulate in the same geographical regions. However, whether T cells…”
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Efficient Induction of T Cells against Conserved HIV-1 Regions by Mosaic Vaccines Delivered as Self-Amplifying mRNA by Moyo, Nathifa, Vogel, Annette B, Buus, Søren, Erbar, Stephanie, Wee, Edmund G, Sahin, Ugur, Hanke, Tomáš

“…Focusing T cell responses on the most vulnerable parts of HIV-1, the functionally conserved regions of HIV-1 proteins, is likely a key prerequisite for vaccine…”
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