Search Results - "Butterfield, D. A."
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Nutritional approaches to modulate oxidative stress in Alzheimer's disease
Published in Current Alzheimer research (01-08-2011)“…Alzheimer's disease (AD) brain is characterized by amyloid β-peptide (Aβ) deposits, neurofibrillary tangles, synapse loss, and extensive oxidative stress…”
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Evidence of increased oxidative damage in subjects with mild cognitive impairment
Published in Neurology (12-04-2005)“…To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes…”
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Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain
Published in Neuroscience (31-03-2010)“…Abstract Adriamycin (ADR) is a chemotherapeutic for the treatment of solid tumors. This quinone-containing anthracycline is well known to produce large amounts…”
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Organic Biogeochemistry in West Mata, NE Lau Hydrothermal Vent Fields
Published in Geochemistry, geophysics, geosystems : G3 (01-04-2021)“…Abstract The impact of submarine hydrothermal systems on organic carbon in the ocean—one of the largest fixed carbon reservoirs on Earth—could be profound…”
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The 1998 eruption of Axial Seamount: New insights on submarine lava flow emplacement from high‐resolution mapping
Published in Geochemistry, geophysics, geosystems : G3 (01-10-2013)“…Axial Seamount, an active submarine volcano on the Juan de Fuca Ridge at 46°N, 130°W, erupted in January 1998 along 11 km of its upper south rift zone. We use…”
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A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury
Published in Neuroscience (22-04-2008)“…Abstract Alzheimer's disease (AD) is associated with β-amyloid accumulation, oxidative stress and mitochondrial dysfunction. However, the effects of genetic…”
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Layer-by-Layer-Assembled Microfiltration Membranes for Biomolecule Immobilization and Enzymatic Catalysis
Published in Langmuir (21-11-2006)“…Multilayer assemblies of polyelectrolytes, for protein immobilization, have been created within the membrane pore domain. This approach was taken for two…”
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Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment
Published in Free radical biology & medicine (01-07-2014)“…Doxorubicin (DOX), one of the most effective anticancer drugs, is known to generate progressive cardiac damage, which is due, in part, to DOX-induced reactive…”
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Vitamin E is essential for Purkinje neuron integrity
Published in Neuroscience (28-02-2014)“…Highlights • Vitamin E deficiency results in elevated oxidative stress in the cerebellum. • Vitamin E deficiency results in impaired motor and cognitive…”
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Calcification and organic production on a Hawaiian coral reef
Published in Marine chemistry (20-12-2011)“…Net ecosystem calcification rates (NEC) and net photosynthesis (NP) were determined from CO 2 seawater parameters on the barrier coral reef of Kaneohe Bay,…”
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Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid β-peptide (1–42) into rat brain: Implications for Alzheimer’s disease
Published in Neuroscience (2005)“…Protein oxidation has been shown to result in loss of protein function. There is increasing evidence that protein oxidation plays a role in the pathogenesis of…”
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Protein oxidation in the brain in Alzheimer's disease
Published in Neuroscience (01-01-2001)“…In this study we used immunohistochemistry and two-dimensional fingerprinting of oxidatively modified proteins (two-dimensional Oxyblot) together to…”
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DIFFERENTIAL EXPRESSION AND REDOX PROTEOMICS ANALYSES OF AN ALZHEIMER DISEASE TRANSGENIC MOUSE MODEL: EFFECTS OF THE AMYLOID-β PEPTIDE OF AMYLOID PRECURSOR PROTEIN
Published in Neuroscience (17-03-2011)“…Among the pathological factors known to be associated with Alzheimer disease (AD), oxidative stress induced by the amyloid-β peptide (Aβ) has been demonstrated…”
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Activity and abundance of denitrifying bacteria in the subsurface biosphere of diffuse hydrothermal vents of the Juan de Fuca Ridge
Published in Biogeosciences (22-11-2012)“…Little is known about fixed nitrogen (N) transformation and elimination at diffuse hydrothermal vents where anoxic fluids are mixed with oxygenated crustal…”
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Modelling phosphorus dynamics in multi-branch river systems: A study of the Black River, Lake Simcoe, Ontario, Canada
Published in The Science of the total environment (15-12-2011)“…High rates of nutrient loading from agricultural and urban development have resulted in surface water eutrophication and groundwater contamination in regions…”
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Sources of organic nitrogen at the serpentinite-hosted Lost City hydrothermal field
Published in Geobiology (01-03-2013)“…The reaction of ultramafic rocks with water during serpentinization at moderate temperatures results in alkaline fluids with high concentrations of reduced…”
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Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants
Published in Neurology (28-01-2003)“…To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that may block this oxidative stress. Brain…”
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Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta(1--42) and A beta(25--35)
Published in Journal of the American Chemical Society (20-06-2001)“…Oxidative stress induced by amyloid beta-peptide (A beta) has been implicated in the neurodegeneration observed in Alzheimer's disease (AD) brain. However, the…”
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Chemical, Physical, and Gel-forming Properties of Oxidized Myofibrils and Whey- and Soy-protein Isolates
Published in Journal of food science (01-08-2000)“…ABSTRACT Myofibrils, oxidized with FeCl3/H2O2/ascorbate, exhibited an increase in carbonyls and amines, SH→SS conversion, peptide scission, myosin…”
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Seismic precursors and magma ascent before the April 2011 eruption at Axial Seamount
Published in Nature geoscience (01-07-2012)“…For volcanoes at submarine rift zones, a direct link between seismicity, seafloor deformation and magma intrusion has not been demonstrated. Recordings from…”
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