Search Results - "Butter, Falk"
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A DNA methylation reader complex that enhances gene transcription
Published in Science (American Association for the Advancement of Science) (07-12-2018)“…DNA methylation generally functions as a repressive transcriptional signal, but it is also known to activate gene expression. In either case, the downstream…”
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2
Misactivation of multiple starvation responses in yeast by loss of tRNA modifications
Published in Nucleic acids research (27-07-2020)“…Abstract Previously, combined loss of different anticodon loop modifications was shown to impair the function of distinct tRNAs in Saccharomyces cerevisiae…”
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Proteotranscriptomics assisted gene annotation and spatial proteomics of Bombyx mori BmN4 cell line
Published in BMC genomics (06-10-2020)“…The process of identifying all coding regions in a genome is crucial for any study at the level of molecular biology, ranging from single-gene cloning to…”
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4
Quantitative Proteomics to Identify Nuclear RNA-Binding Proteins of Malat1
Published in International journal of molecular sciences (10-02-2020)“…The long non-coding RNA Malat1 has been implicated in several human cancers, while the mechanism of action is not completely understood. As RNAs in cells…”
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Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression
Published in Cell death & disease (01-04-2022)“…Overexpression of histone deacetylases (HDACs) in cancer commonly causes resistance to genotoxic-based therapies. Here, we report on the novel mechanism…”
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6
The RNA fold interactome of evolutionary conserved RNA structures in S. cerevisiae
Published in Nature communications (03-06-2020)“…RNA-binding proteins play key roles in regulation of gene expression via recognition of structural features in RNA molecules. Here we apply a quantitative RNA…”
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7
The nuclear proteome of Trypanosoma brucei
Published in PloS one (20-07-2017)“…Trypanosoma brucei is a protozoan flagellate that is transmitted by tsetse flies into the mammalian bloodstream. The parasite has a huge impact on human health…”
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A novel SNF2 ATPase complex in Trypanosoma brucei with a role in H2A.Z-mediated chromatin remodelling
Published in PLoS pathogens (01-06-2022)“…A cascade of histone acetylation events with subsequent incorporation of a histone H2A variant plays an essential part in transcription regulation in various…”
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The developmental proteome of Drosophila melanogaster
Published in Genome research (01-07-2017)“…is a widely used genetic model organism in developmental biology. While this model organism has been intensively studied at the RNA level, a comprehensive…”
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10
Proteotranscriptomics – A facilitator in omics research
Published in Computational and structural biotechnology journal (01-01-2022)“…Applications in omics research, such as comparative transcriptomics and proteomics, require the knowledge of the species-specific gene sequence and benefit…”
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Correction to: Proteotranscriptomics assisted gene annotation and spatial proteomics of Bombyx mori BmN4 cell line
Published in BMC genomics (12-11-2020)“…An amendment to this paper has been published and can be accessed via the original article…”
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The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1
Published in Nature communications (11-05-2021)“…Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans…”
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Quantifying post-transcriptional regulation in the development of Drosophila melanogaster
Published in Nature communications (26-11-2018)“…Even though proteins are produced from mRNA, the correlation between mRNA levels and protein abundances is moderate in most studies, occasionally attributed to…”
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The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei
Published in Scientific reports (15-09-2021)“…The biosynthesis of ribosomes is a complex cellular process involving ribosomal RNA, ribosomal proteins and several further trans-acting factors. DExD/H box…”
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15
Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators
Published in Genome research (01-12-2013)“…Telomeres are actively transcribed into telomeric repeat-containing RNA (TERRA), which has been implicated in the regulation of telomere length and…”
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TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
Published in Nature (London) (23-08-2012)“…Genome-wide association studies in combination with functional analyses identify a genetic variant that explains why anti-tumour necrosis factor therapy, used…”
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Revealing the Arabidopsis AtGRP7 mRNA binding proteome by specific enhanced RNA interactome capture
Published in BMC plant biology (14-06-2024)“…The interaction of proteins with RNA in the cell is crucial to orchestrate all steps of RNA processing. RNA interactome capture (RIC) techniques have been…”
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Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus
Published in Nature communications (14-09-2024)“…Cell-cell junctions, and specifically desmosomes, are crucial for robust intercellular adhesion. Desmosomal function is compromised in the autoimmune…”
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Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition
Published in Genome research (01-07-2017)“…During the maternal-to-zygotic transition (MZT), transcriptionally silent embryos rely on post-transcriptional regulation of maternal mRNAs until zygotic…”
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Quantitative Proteomics Uncovers Novel Factors Involved in Developmental Differentiation of Trypanosoma brucei
Published in PLoS pathogens (24-02-2016)“…Developmental differentiation is a universal biological process that allows cells to adapt to different environments to perform specific functions. African…”
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