Search Results - "Buttenshaw, Ron"

Oncogenic PIK3CA mutations in colorectal cancers and polyps by Whitehall, Vicki L.J., Rickman, Celestine, Bond, Catherine E., Ramsnes, Ingunn, Greco, Sonia A., Umapathy, Aarti, McKeone, Diane, Faleiro, Rebecca J., Buttenshaw, Ron L., Worthley, Daniel L., Nayler, Sam, Zhao, Zhen Zhen, Montgomery, Grant W., Mallitt, Kylie-Ann, Jass, Jeremy R., Matsubara, Nagahide, Notohara, Kenji, Ishii, Tatsuhiro, Leggett, Barbara A.

“…Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic…”
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Chromosomal instability in BRAF mutant, microsatellite stable colorectal cancers by Bond, Catherine E, Umapathy, Aarti, Buttenshaw, Ron L, Wockner, Leesa, Leggett, Barbara A, Whitehall, Vicki L J

“…The BRAF oncogene is mutated in 15% of sporadic colorectal cancers. Approximately half of these BRAF mutant cancers demonstrate frequent frameshift mutations…”
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p53 mutation is common in microsatellite stable, BRAF mutant colorectal cancers by Bond, Catherine E., Umapathy, Aarti, Ramsnes, Ingunn, Greco, Sonia A., Zhen Zhao, Zhen, Mallitt, Kylie-Ann, Buttenshaw, Ron L., Montgomery, Grant W., Leggett, Barbara A., Whitehall, Vicki L.J.

“…The majority of “serrated pathway” colorectal cancers have mutation of the BRAF oncogene and display the CpG island methylator phenotype (CIMP). Half these…”
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Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development by Loh, Kim, Chia, June A., Greco, Sonia, Cozzi, Sarah-Jane, Buttenshaw, Ron L., Bond, Catherine E., Simms, Lisa A., Pike, Tanya, Young, Joanne P., Jass, Jeremy R., Spring, Kevin J., Leggett, Barbara A., Whitehall, Vicki L. J.

“…Bone morphogenic proteins (BMPs) are members of the TGFB growth factor superfamily with well‐described functions in bone formation. Although disrupted BMP…”
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Hyperplastic Polyposis Syndrome Is Associated With Cigarette Smoking, Which May Be a Modifiable Risk Factor by WALKER, R. Griff, LANDMANN, Juergen K, HEWETT, David G, WORTHLEY, Daniel L, BUTTENSHAW, Ron L, KNIGHT, Ngaire, WEBB, Penny M, WHITEMAN, David C, WHITEHALL, Vicki L, LEGGETT, Barbara A

“…Hyperplastic polyposis syndrome (HPS) confers an increased risk of colorectal cancer and is difficult to manage clinically. Because both polyps and resultant…”
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Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers by SIMMS, L. A, RADFORD-SMITH, G, BIDEN, K. G, BUTTENSHAW, R, CUMMINGS, M, JASS, J. R, YOUNG, J, MELTZER, S. J, LEGGETT, B. A

“…Though most colorectal cancers show allelic losses, a subset of colorectal cancers (microsatellite instability or MSI-positive cancers) develop numerous small…”
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No evidence of increased risk of colorectal cancer in individuals heterozygous for the Cys282Tyr haemochromatosis mutation by Macdonald, Graeme A, Tarish, Jabsar, Whitehall, Vicki Jl, M, Sally J, Mellick, George D, Buttenshaw, Ron L, Johnson, Anthony G, Young, Joanne, Leggett, Barbara A

“…Background and Aims : Previous studies have suggested that increased body iron stores and heterozygosity for haemochromatosis are associated with an increased…”
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Features of Colorectal Cancers with High-Level Microsatellite Instability Occurring in Familial and Sporadic Settings : Parallel Pathways of Tumorigenesis by Young, Joanne, Simms, Lisa A, Biden, Kelli G, Wynter, Coral, Whitehall, Vicki, Karamatic, Rozemary, George, Jill, Goldblatt, Jack, Walpole, Ian, Robin, Sally-Anne, Borten, Michael M, Stitz, Russell, Searle, Jeffrey, McKeone, Diane, Fraser, Leigh, Purdie, David R, Podger, Kay, Price, Rachael, Buttenshaw, Ron, Walsh, Michael D, Barker, Melissa, Leggett, Barbara A, Jass, Jeremy R

“…High-level microsatellite instability (MSI-H) is demonstrated in 10 to 15% of sporadic colorectal cancers and in most cancers presenting in the inherited…”
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Abstract 106: Chromosomal instability in BRAF mutant, microsatellite stable colorectal cancers by Bond, Catherine E., Umapathy, Aarti, Buttenshaw, Ron L., Wockner, Leesa, Leggett, Barbara A., Whitehall, Vicki LJ

“…BRAF mutant colorectal cancers can be stratified according to the presence of microsatellite instability (MSI). MSI cancers with a BRAF mutation are associated…”
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Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer by Young, Joanne, Barker, Melissa A, Simms, Lisa A, Walsh, Michael D, Biden, Kelli G, Buchanan, Daniel, Buttenshaw, Ron, Whitehall, Vicki L J, Arnold, Sven, Jackson, Leigh, Kambara, Takeshi, Spring, Kevin J, Jenkins, Mark A, Walker, Graeme J, Hopper, John L, Leggett, Barbara A, Jass, Jeremy R

“…Recently, an alternative pathway of tumorigenesis has been identified in the colorectum associated with serrated precursor lesions, variable levels of…”
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199 DNA Methylation Throughout the Normal Human Colorectum: Evidence of An Epigenetic Field Effect by Worthley, Daniel L, Whitehall, Vicki L, Buttenshaw, Ron, Mallitt, Kylie-Ann, Le Leu, Richard K, Young, Graeme P, Leggett, Barbara A

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T2076 DNA Methylation Profiles Within Normal Human Colorectal Mucosa Are Gene Specific and Influenced By Region, Patient Age and Pathology by Worthley, Daniel L, Whitehall, Vicki, Buttenshaw, Ron, Scott, Justin R, Leggett, Barbara A

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Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population by Biden, K, Young, J, Buttenshaw, R, Searle, J, Cooksley, G, Xu, D B, Leggett, B

“…The tumor suppressor gene CDKN2A (MTS1/p16), located on chromosome 9p21, is inactivated in a variety of tumors including melanomas and tumors of the biliary…”
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Genomic instability occurs in colorectal carcinomas but not in adenomas by Young, J, Leggett, B, Gustafson, C, Ward, M, Searle, J, Thomas, L, Buttenshaw, R, Chenevix-Trench, G

“…Genomic instability, as demonstrated by the presence of additional alleles at short tandemly repeated (STR) loci, has recently been observed in colorectal…”
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Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability by BIDEN, K. G, SIMMS, L. A, YOUNG, J, CUMMINGS, M, BUTTENSHAW, R, SCHOCH, E, SEARLE, J, GOBE, G, JASS, J. R, MELTZER, S. J, LEGGETT, B. A

“…Bcl-2 is known to inhibit apoptosis and is thought to play a role in colorectal tumour development. Studies of the promoter region of bcl-2 have indicated the…”
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A family with attenuated familial adenomatous polyposis due to a mutation in the alternatively spliced region of APC exon 9 by Young, Joanne, Simms, Lisa A., Tarish, Jabbar, Buttenshaw, Ron, Knight, Ngaire, Anderson, Gregory J., Bell, Andrew, Leggett, Barbara

“…A family is presented with attenuated familial adenomatous polyposis of variable phenotype. The clinical features range from sparse right‐sided polyposis and…”
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Angiogenic factor VEGF is decreased in human colorectal neoplasms showing DNA microsatellite instability by Wynter, Coral V. A., Simms, Lisa A., Buttenshaw, Ron L., Biden, Kelli G., Young, Joanne, Leggett, Barbara A., Conrad, Rod J., Schoch, Estelle M., Jass, Jeremy R., Praga Pillay, S.

“…Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are two important determinants of angiogenesis in human cancers. Expression…”
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Features of Colorectal Cancers with High-Level Microsatellite Instability Occurring in Familial and Sporadic Settings by Young, Joanne, Simms, Lisa A., Biden, Kelli G., Wynter, Coral, Whitehall, Vicki, Karamatic, Rozemary, George, Jill, Goldblatt, Jack, Walpole, Ian, Robin, Sally-Anne, Borten, Michael M., Stitz, Russell, Searle, Jeffrey, McKeone, Diane, Fraser, Leigh, Purdie, David R., Podger, Kay, Price, Rachael, Buttenshaw, Ron, Walsh, Michael D., Barker, Melissa, Leggett, Barbara A., Jass, Jeremy R.

“…High-level microsatellite instability (MSI-H) is demonstrated in 10 to 15% of sporadic colorectal cancers and in most cancers presenting in the inherited…”
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Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers by Young, J, Buttenshaw, R, Butterworth, L, Ward, M, Searle, J, Leggett, B, Chenevix-Trench, G

“…L-myc is a nuclear oncogene which is sometimes activated late in tumourigenesis. Digestion of DNA with EcoRI reveals a simple restriction fragment length…”
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