Search Results - "Butschek, Grant J"

Aptamer-Based Imaging of Polyisoprenoids in the Malaria Parasite by Zimbres, Flavia M, Merino, Emilio F, Butschek, Grant J, Butler, Joshua H, Ducongé, Frédéric, Cassera, Maria B

“…Dolichols are isoprenoid end-products of the mevalonate and 2 -methyl-D-erythritol-4-phosphate pathways. The synthesis of dolichols is initiated with the…”
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Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor by Valenciano, Ana Lisa, Fernández-Murga, Maria L., Merino, Emilio F., Holderman, Nicole R., Butschek, Grant J., Shaffer, Karl J., Tyler, Peter C., Cassera, Maria Belen

“…The shikimate pathway, a metabolic pathway absent in humans, is responsible for the production of chorismate, a branch point metabolite. In the malaria…”
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Malaria Box-Inspired Discovery of N‑Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials by Mathew, Jopaul, Ding, Sha, Kunz, Kevin A, Stacy, Emily E, Butler, Joshua H, Haney, Reagan S, Merino, Emilio F, Butschek, Grant J, Rizopoulos, Zaira, Totrov, Maxim, Cassera, Maria B, Carlier, Paul R

“…Virtual ligand screening of a publicly available database of antimalarial hits using a pharmacophore derived from antimalarial MMV008138 identified…”
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Enantiopure Benzofuran-2-carboxamides of 1‑Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro by Almolhim, Hanan, Ding, Sha, Butler, Joshua H, Bremers, Emily K, Butschek, Grant J, Slebodnick, Carla, Merino, Emilio F, Rizopoulos, Zaira, Totrov, Maxim, Cassera, Maria B, Carlier, Paul R

“…The tetrahydro-β-carboline scaffold has proven fertile ground for the discovery of antimalarial agents (e.g., MMV008138 (1) and cipargamin (2)). Similarity…”
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