Search Results - "Buts, Lieven"
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Toxin–antitoxin modules as bacterial metabolic stress managers
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01-12-2005)“…Bacterial genomes frequently contain operons that encode a toxin and its antidote. These ‘toxin–antitoxin (TA) modules’ have an important role in bacterial…”
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Hydrophobic Surface Patches on LolA of Pseudomonas aeruginosa Are Essential for Lipoprotein Binding
Published in Journal of molecular biology (03-09-2010)“…Many lipoproteins reside in the outer membrane (OM) of Gram-negative bacteria, and their biogenesis is dependent on the Lol (localization of lipoproteins)…”
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Structural and Thermodynamic Characterization of Vibrio fischeri CcdB
Published in The Journal of biological chemistry (19-02-2010)“…CcdBVfi from Vibrio fischeri is a member of the CcdB family of toxins that poison covalent gyrase-DNA complexes. In solution CcdBVfi is a dimer that unfolds to…”
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Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia coli
Published in Biology (Basel, Switzerland) (01-07-2013)“…Fimbriae are long, proteinaceous adhesion organelles expressed on the bacterial envelope, evolutionarily adapted by Escherichia coli strains for the…”
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Chloroplasts Assemble the Major Subunit FaeG of Escherichia coli F4 (K88) Fimbriae to Strand-swapped Dimers
Published in Journal of molecular biology (04-05-2007)“…F4 fimbriae encoded by the fae operon are the major colonization factors associated with porcine neonatal and postweaning diarrhoea caused by enterotoxigenic…”
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Structural basis for the recognition of complex‐type biantennary oligosaccharides by Pterocarpus angolensis lectin
Published in The FEBS journal (01-06-2006)“…The crystal structure of Pterocarpus angolensis lectin is determined in its ligand‐free state, in complex with the fucosylated biantennary complex type…”
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Crystal Structure of Pterocarpus angolensis Lectin in Complex with Glucose, Sucrose, and Turanose
Published in The Journal of biological chemistry (02-05-2003)“…The crystal structure of the Man/Glc-specific seed lectin from Pterocarpus angolensis was determined in complex with methyl-α-d-glucose, sucrose, and turanose…”
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Weak protein-protein interactions in lectins: the crystal structure of a vegetative lectin from the legume Dolichos biflorus
Published in Journal of molecular biology (25-05-2001)“…The legume lectins are widely used as a model system for studying protein-carbohydrate and protein-protein interactions. They exhibit a fascinating quaternary…”
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9
Rejuvenation of CcdB-Poisoned Gyrase by an Intrinsically Disordered Protein Domain
Published in Molecular cell (31-07-2009)“…Toxin-antitoxin modules are small regulatory circuits that ensure survival of bacterial populations under challenging environmental conditions. The ccd…”
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Methionine sulfoxide reductase B from Corynebacterium diphtheriae catalyzes sulfoxide reduction via an intramolecular disulfide cascade
Published in The Journal of biological chemistry (13-03-2020)“…Corynebacterium diphtheriae is a human pathogen that causes diphtheria. In response to immune system-induced oxidative stress, C. diphtheriae expresses…”
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Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding
Published in Nucleic acids research (30-01-2015)“…Toxin-antitoxin (TA) modules are pairs of genes essential for bacterial regulation upon environmental stresses. The mazEF module encodes the MazF toxin and its…”
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Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity
Published in Structure (London) (01-11-2016)“…Src kinase activity is controlled by various mechanisms involving a coordinated movement of kinase and regulatory domains. Notwithstanding the extensive…”
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The Plasticity of the β-Trefoil Fold Constitutes an Evolutionary Platform for Protease Inhibition
Published in The Journal of biological chemistry (23-12-2011)“…Proteases carry out a number of crucial functions inside and outside the cell. To protect the cells against the potentially lethal activities of these enzymes,…”
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Molecular Identification of β-Citrylglutamate Hydrolase as Glutamate Carboxypeptidase 3
Published in The Journal of biological chemistry (04-11-2011)“…β-Citrylglutamate (BCG), a compound present in adult testis and in the CNS during the pre- and perinatal periods is synthesized by an intracellular enzyme…”
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15
Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics
Published in Nucleic acids research (02-06-2014)“…The Staphylococcus aureus genome contains three toxin-antitoxin modules, including one mazEF module, SamazEF. Using an on-column separation protocol we are…”
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Structural insights into the intertwined dimer of fyn SH 2
Published in Protein science (01-12-2015)“…Abstract Src homology 2 domains are interaction modules dedicated to the recognition of phosphotyrosine sites incorporated in numerous proteins found in…”
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Mycoredoxin-1 is one of the missing links in the oxidative stress defence mechanism of Mycobacteria
Published in Molecular microbiology (01-11-2012)“…Summary To survive hostile conditions, the bacterial pathogen Mycobacterium tuberculosis produces millimolar concentrations of mycothiol as a redox buffer…”
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Study of the Structural and Dynamic Effects in the FimH Adhesin upon α‑d‑Heptyl Mannose Binding
Published in Journal of medicinal chemistry (27-02-2014)“…Uropathogenic Escherichia coli cause urinary tract infections by adhering to mannosylated receptors on the human urothelium via the carbohydrate-binding domain…”
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Small-Angle X-Ray Scattering- and Nuclear Magnetic Resonance-Derived Conformational Ensemble of the Highly Flexible Antitoxin PaaA2
Published in Structure (London) (10-06-2014)“…Antitoxins from prokaryotic type II toxin-antitoxin modules are characterized by a high degree of intrinsic disorder. The description of such highly flexible…”
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Structural insights into the intertwined dimer of fyn SH2
Published in Protein science (01-12-2015)“…Src homology 2 domains are interaction modules dedicated to the recognition of phosphotyrosine sites incorporated in numerous proteins found in intracellular…”
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