Search Results - "Butreddy, Arun"

PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery by Butreddy, Arun, Gaddam, Rajendra Prasad, Kommineni, Nagavendra, Dudhipala, Narendar, Voshavar, Chandrashekhar

“…Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide (PLGA) or polylactic acid (PLA) based microspheres have been…”
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Exosomes as Naturally Occurring Vehicles for Delivery of Biopharmaceuticals: Insights from Drug Delivery to Clinical Perspectives by Butreddy, Arun, Kommineni, Nagavendra, Dudhipala, Narendar

“…Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics owing to their natural origin, their ability to mediate intercellular…”
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A Comprehensive Review of mRNA Vaccines by Gote, Vrinda, Bolla, Pradeep Kumar, Kommineni, Nagavendra, Butreddy, Arun, Nukala, Pavan Kumar, Palakurthi, Sushesh Srivatsa, Khan, Wahid

“…mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy,…”
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Continuous twin screw granulation – An advanced alternative granulation technology for use in the pharmaceutical industry by Bandari, Suresh, Nyavanandi, Dinesh, Kallakunta, Venkata Raman, Janga, Kartik Yadav, Sarabu, Sandeep, Butreddy, Arun, Repka, Michael A.

“…[Display omitted] •Twin screw granulation is an economical, industrially-scalable, continuous process.•Different TSG techniques are potential alternatives of…”
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Versatility of Liposomes for Antisense Oligonucleotide Delivery: A Special Focus on Various Therapeutic Areas by Gupta, Raghav, Salave, Sagar, Rana, Dhwani, Karunakaran, Bharathi, Butreddy, Arun, Benival, Derajram, Kommineni, Nagavendra

“…Nucleic acid therapeutics, specifically antisense oligonucleotides (ASOs), can effectively modulate gene expression and protein function, leading to…”
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Leveraging spray drying technique for advancing biologic product development–A mini review by Donthi, Mahipal Reddy, Butreddy, Arun, Saha, Ranendra Narayan, Kesharwani, Prashant, Dubey, Sunil Kumar

“…Over the last 15 years, spray drying (SD), as an alternative to lyophilization, to manufacture and increase the stability of biologics has demonstrated…”
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Hydroxypropyl methylcellulose acetate succinate as an exceptional polymer for amorphous solid dispersion formulations: A review from bench to clinic by Butreddy, Arun

“…[Display omitted] Amorphous solid dispersions (ASDs) are a proven system for achieving a supersaturated state of drug, in which the concentration of drug is…”
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Freeze-drying for the preservation of immunoengineering products by Kommineni, Nagavendra, Butreddy, Arun, Sainaga Jyothi, Vaskuri G.S., Angsantikul, Pavimol

“…Immunoengineering technologies harness the power of immune system modulators such as monoclonal antibodies, cytokines, and vaccines to treat myriad diseases…”
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Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development by Butreddy, Arun, Bandari, Suresh, Repka, Michael A.

“…An industrially feasible approach to overcome the solubility and bioavailability limitations of poorly soluble active pharmaceutical ingredients is the…”
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Biosimilar monoclonal antibodies: Challenges and approaches towards formulation by Goli, Venkata Appa Reddy, Butreddy, Arun

“…Many biologic drug products, particularly monoclonal antibodies (mAbs), were off-patented between 2015 and 2020, and this process is continuing as the number…”
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3D printing in personalized drug delivery: An overview of hot-melt extrusion-based fused deposition modeling by Dumpa, Nagireddy, Butreddy, Arun, Wang, Honghe, Komanduri, Neeraja, Bandari, Suresh, Repka, Michael A.

“…[Display omitted] Advancements in pharmaceutical technologies have led to the personalization of therapies over the last decade. Three-dimensional printing…”
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Instability of therapeutic proteins — An overview of stresses, stabilization mechanisms and analytical techniques involved in lyophilized proteins by Butreddy, Arun, Janga, Karthik Yadav, Ajjarapu, Srinivas, Sarabu, Sandeep, Dudhipala, Narendar

“…Solid-state is the preferred choice for storage of protein therapeutics to improve stability and preserve the biological activity by decreasing the physical…”
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Lyophilization of Small-Molecule Injectables: an Industry Perspective on Formulation Development, Process Optimization, Scale-Up Challenges, and Drug Product Quality Attributes by Butreddy, Arun, Dudhipala, Narendar, Janga, Karthik Yadav, Gaddam, Rajendra Prasad

“…Lyophilization is a pivotal manufacturing process to obtain a stable drug product that is unstable as a ready-to-use formulation. Some formulations may require…”
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Polymer-Assisted Aripiprazole–Adipic Acid Cocrystals Produced by Hot Melt Extrusion Techniques by Butreddy, Arun, Sarabu, Sandeep, Bandari, Suresh, Dumpa, Nagireddy, Zhang, Feng, Repka, Michael A

“…Pharmaceutical cocrystals offer a promising strategy to increase the solubility and dissolution rate of poorly soluble drugs. However, their manufacturing…”
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Extended release pellets prepared by hot melt extrusion technique for abuse deterrent potential: Category-1 in-vitro evaluation by Butreddy, Arun, Sarabu, Sandeep, Dumpa, Nagireddy, Bandari, Suresh, Repka, Michael A.

“…[Display omitted] The objective of the present study was to develop extended-release (ER) hot-melt extruded (HME) abuse-deterrent pellets of acetaminophen, a…”
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Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions: Impact of polymeric combinations on supersaturation kinetics and dissolution performance by Butreddy, Arun, Sarabu, Sandeep, Almutairi, Mashan, Ajjarapu, Srinivas, Kolimi, Praveen, Bandari, Suresh, Repka, Michael A.

“…[Display omitted] Nucleation inhibition and maintenance of drug supersaturation over a prolonged period are desirable for improving oral absorption of…”
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Hot-Melt extrusion coupled with pressurized carbon dioxide for enhanced processability of pharmaceutical polymers and drug delivery applications – An integrated review by Almutairi, Mashan, Srinivasan, Priyanka, Zhang, Peilun, Austin, Fischer, Butreddy, Arun, Alharbi, Muteb, Bandari, Suresh, Ashour, Eman A., Repka, Michael A.

“…[Display omitted] Hot-melt extrusion (HME) technology is one of the primary approaches that has been implemented in recent years to overcome poor drug…”
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New Applications of Hot Melt Extrusion Techniques for Advancing Oral Drug Delivery by Butreddy, Arun

“…Hot melt extrusion (HME) is a promising technology in the pharmaceutical field, as evidenced by its application in the development of various formulations such…”
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Lignin: Drug/Gene Delivery and Tissue Engineering Applications by Kumar, Raj, Butreddy, Arun, Kommineni, Nagavendra, Reddy, Pulikanti Guruprasad, Bunekar, Naveen, Sarkar, Chandrani, Dutt, Sunil, Mishra, Vivek K, Aadil, Keshaw Ram, Mishra, Yogendra Kumar, Oupicky, David, Kaushik, Ajeet

“…Lignin is an abundant renewable natural biopolymer. Moreover, a significant development in lignin pretreatment and processing technologies has opened a new…”
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SNAC for Enhanced Oral Bioavailability: An Updated Review by Kommineni, Nagavendra, Sainaga Jyothi, Vaskuri G S, Butreddy, Arun, Raju, Saka, Shapira, Tovi, Khan, Wahid, Angsantikul, Pavimol, Domb, Abraham J.

“…  The delivery of proteins and peptides via an oral route poses numerous challenges to improve the oral bioavailability and patient compliance. To overcome…”
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