Search Results - "Butler Browne, G."
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PABPN1 gene therapy for oculopharyngeal muscular dystrophy
Published in Nature communications (31-03-2017)“…Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant, late-onset muscle disorder characterized by ptosis, swallowing difficulties, proximal limb…”
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The prevalence of malnutrition according to the new ESPEN definition in four diverse populations
Published in Clinical nutrition (Edinburgh, Scotland) (01-06-2016)“…Summary Background & aims Consensus on the definition of malnutrition has not yet been reached. Recently, The European Society for Clinical Nutrition and…”
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Skeletal muscle adaptations to physical inactivity and subsequent retraining in young men
Published in Biogerontology (Dordrecht) (01-06-2013)“…Skeletal muscle structure and function are markedly affected by chronic disuse. With unloading, muscle mass is lost at rate of about 0.4 %/day but little is…”
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Muscle weakness and atrophy are associated with decreased regenerative capacity and changes in mTOR signaling in skeletal muscles of venerable (18-24-month-old) dystrophic mdx mice
Published in Muscle & nerve (01-06-2010)“…The muscles of mdx mice progressively deteriorate with age. We wanted to know whether this is associated with a decrease in regenerative capacity and/or…”
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Satellite cell dysfunction contributes to the progressive muscle atrophy in myotonic dystrophy type 1
Published in Neuropathology and applied neurobiology (01-11-2009)“…Aims: Myotonic dystrophy type 1 (DM1), one of the most common forms of inherited neuromuscular disorders in the adult, is characterized by progressive muscle…”
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In vivo satellite cell activation via Myf5 and MyoD in regenerating mouse skeletal muscle
Published in Journal of cell science (01-09-1999)“…Regeneration of adult skeletal muscle is an asynchronous process requiring the activation, proliferation and fusion of satellite cells, to form new muscle…”
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Diagnostic criteria for sarcopenia and physical performance
Published in AGE (01-02-2014)“…Relative and absolute muscle mass and muscle strength are used as diagnostic criteria for sarcopenia. We aimed to assess which diagnostic criteria are most…”
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Slow myosin heavy chain expression in the absence of muscle activity
Published in American Journal of Physiology: Cell Physiology (01-01-2009)“…Innervation has been generally accepted to be a major factor involved in both triggering and maintaining the expression of slow myosin heavy chain (MHC-1) in…”
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Androgen replacement therapy improves function in male rat muscles independently of hypertrophy and activation of the Akt/mTOR pathway
Published in Acta Physiologica (01-04-2009)“…Aim: We analysed the effect of physiological doses of androgens following orchidectomy on skeletal muscle and bone of male rats, as well as the relationships…”
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Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults
Published in AGE (2014)“…Pathological obstruction in lungs leads to severe decreases in muscle strength and mobility in patients suffering from chronic obstructive pulmonary disease…”
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11
IGF-1 induces human myotube hypertrophy by increasing cell recruitment
Published in Experimental cell research (10-09-2004)“…Insulin-like growth factor-1 (IGF-1) has been shown in rodents (i) in vivo to induce muscle fiber hypertrophy and to prevent muscle mass decline with age and…”
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Differential recovery of neuromuscular function after nerve/muscle injury induced by crude venom from Notechis scutatus, cardiotoxin from Naja atra and bupivacaine treatments in mice
Published in Neuroscience research (01-07-2007)“…Different neuromyotoxic agents are frequently used in rodent models of skeletal nerve/muscle injury and repair. However, their differential effects are not…”
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13
Defective satellite cells in congenital myotonic dystrophy
Published in Human molecular genetics (15-09-2001)“…In this study we have developed an in vitro cell culture system which displays the majority of the defects previously described for congenital myotonic…”
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Diabetes provides an unfavorable environment for muscle mass and function after muscle injury in mice
Published in Pathobiology (Basel) (01-01-2007)“…It is of common knowledge that diabetes decreases skeletal muscle contractility and induces atrophy. However, how hyperglycemia and insulin deficiency modify…”
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Satellite cells and training in the elderly
Published in Scandinavian journal of medicine & science in sports (01-02-2003)“…In the present review, we describe the effects of ageing on human muscle fibres, underlining that each human muscle is unique, meaning that the phenotype…”
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The mitotic clock in skeletal muscle regeneration, disease and cell mediated gene therapy
Published in Acta physiologica Scandinavica (01-05-2005)“…The regenerative capacity of skeletal muscle will depend on the number of available satellite cells and their proliferative capacity. We have measured both…”
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Human muscle precursor cell regeneration in the mouse host is enhanced by growth factors
Published in Human gene therapy (01-11-2004)“…The aim of this study was to optimize human muscle formation in vivo from implanted human muscle precursor cells. We transplanted donor muscle precursor cells…”
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Skeletal muscle regeneration and the mitotic clock
Published in Experimental gerontology (01-09-2000)“…Regeneration of muscle fibers following damage requires activation of quiescent satellite cells, their proliferation and finally their differentiation and…”
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Replicative potential and telomere length in human skeletal muscle: implications for satellite cell-mediated gene therapy
Published in Human gene therapy (10-08-1997)“…In this study, we have evaluated the ability of human satellite cells isolated from subjects aged from 5 days to 86 years to proliferate in culture. Cells were…”
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Extended amplification in vitro and replicative senescence: key factors implicated in the success of human myoblast transplantation
Published in Human gene therapy (10-08-2003)“…The limited success of human myoblast transplantation has been related to immune rejection, poor survival, and limited spread of injected myoblasts after…”
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