Search Results - "Butler, V."

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A by Butler, Kyle V, Kalin, Jay, Brochier, Camille, Vistoli, Guilio, Langley, Brett, Kozikowski, Alan P

“…Structure-based drug design combined with homology modeling techniques were used to develop potent inhibitors of HDAC6 that display superior selectivity for…”
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Saccharides enhance iron bioavailability to Southern Ocean phytoplankton by Hassler, Christel S., Schoemann, Véronique, Nichols, Carol Mancuso, Butler, Edward C. V., Boyd, Philip W., Karl, David M.

“…Iron limits primary productivity in vast regions of the ocean. Given that marine phytoplankton contribute up to 40% of global biological carbon fixation, it is…”
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Probing Cosmic Reionization and Molecular Gas Growth with TIME by Sun, G., Chang, T.-C., Uzgil, B. D., Bock, J. J., Bradford, C. M., Butler, V., Caze-Cortes, T., Cheng, Y.-T., Cooray, A., Crites, A. T., Hailey-Dunsheath, S., Emerson, N., Frez, C., Hoscheit, B. L., Hunacek, J., Keenan, R. P., Li, C. T., Madonia, P., Marrone, D. P., Moncelsi, L., Shiu, C., Trumper, I., Turner, A., Weber, A., Wei, T. S., Zemcov, M.

“…Abstract Line intensity mapping (LIM) provides a unique and powerful means to probe cosmic structures by measuring the aggregate line emission from all…”
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Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists by Chen, Xin, McCorvy, John D, Fischer, Matthew G, Butler, Kyle V, Shen, Yudao, Roth, Bryan L, Jin, Jian

“…Biased ligands (also known as functionally selective ligands) of G protein-coupled receptors are valuable tools for dissecting the roles of G protein-dependent…”
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Strategies to customize responsible gambling messages: a review and focus group study by Gainsbury, Sally M, Abarbanel, Brett L L, Philander, Kahlil S, Butler, Jeffrey V

“…Responsible gambling messages are widely used as a tool to enable informed choice and encourage appropriate gambling behavior. It is generally accepted that…”
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Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase by Jain, Rinku, Butler, Kyle V., Coloma, Javier, Jin, Jian, Aggarwal, Aneel K.

“…The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 Å) of ZIKV NS5 methyltransferase bound to a novel…”
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Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8 by Ma, Anqi, Yu, Wenyu, Li, Fengling, Bleich, Rachel M, Herold, J. Martin, Butler, Kyle V, Norris, Jacqueline L, Korboukh, Victoria, Tripathy, Ashutosh, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Vedadi, Masoud, Brown, Peter J, Jin, Jian

“…The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). Monomethylation of H4K20…”
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Osteoarthritis Classification Scales: Interobserver Reliability and Arthroscopic Correlation by Wright, Rick W, Wright, Rick W, Ross, James R, Haas, Amanda K, Huston, Laura J, Garofoli, Elizabeth A, Harris, David, Patel, Kushal, Pearson, David, Schutzman, Jake, Tarabichi, Majd, Ying, David, Albright, John P, Allen, Christina R, Amendola, Annunziato, Anderson, Allen F, Andrish, Jack T, Annunziata, Christopher C, Arciero, Robert A, Bach, Bernard R, Baker, Champ L, Bartolozzi, Arthur R, Baumgarten, Keith M, Bechler, Jeffery R, Berg, Jeffrey H, Bernas, Geoffrey A, Brockmeier, Stephen F, Brophy, Robert H, Bush-Joseph, Charles A, Butler V, J Brad, Campbell, John D, Carpenter, James E, Cole, Brian J, Cooper, Daniel E, Cooper, Jonathan M, Cox, Charles L, Creighton, R Alexander, Dahm, Diane L, David, Tal S, DeBerardino, Thomas M, Dunn, Warren R, Flanigan, David C, Frederick, Robert W, Ganley, Theodore J, Gatt, Charles J, Gecha, Steven R, Giffin, James Robert, Hame, Sharon L, Hannafin, Jo A, Harner, Christopher D, Harris, Norman Lindsay, Hechtman, Keith S, Hershman, Elliott B, Hoellrich, Rudolf G, Hosea, Timothy M, Johnson, David C, Johnson, Timothy S, Jones, Morgan H, Kaeding, Christopher C, Kamath, Ganesh V, Klootwyk, Thomas E, Lantz, Brett A, Levy, Bruce A, Ma, C Benjamin, Maiers, G Peter, Mann, Barton, Marx, Robert G, Matava, Matthew J, Mathien, Gregory M, McAllister, David R, McCarty, Eric C, McCormack, Robert G, Miller, Bruce S, Nissen, Carl W, O’Neill, Daniel F, Owens, LTC Brett D, Parker, Richard D, Purnell, Mark L, Ramappa, Arun J, Rauh, Michael A, Rettig, Arthur, Sekiya, Jon K, Shea, Kevin G, Sherman, Orrin H, Slauterbeck, James R, Smith, Matthew V, Spang, Jeffrey T, Spindler, Kurt P, Stuart, Michael J, Svoboda, LTC Steven J, Taft, Timothy N, Tenuta, COL Joachim J, Tingstad, Edwin M, Vidal, Armando F, Viskontas, Darius G, White, Richard A, Williams, James S, Wolcott, Michelle L, Wolf, Brian R, York, James J

“…BACKGROUND:Osteoarthritis of the knee is commonly diagnosed and monitored with radiography. However, the reliability of radiographic classification systems for…”
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Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase by Butler, Kyle V, Ma, Anqi, Yu, Wenyu, Li, Fengling, Tempel, Wolfram, Babault, Nicolas, Pittella-Silva, Fabio, Shao, Jason, Wang, Junyi, Luo, Minkui, Vedadi, Masoud, Brown, Peter J, Arrowsmith, Cheryl H, Jin, Jian

“…Selective inhibitors of protein lysine methyltransferases, including SET domain-containing protein 8 (SETD8), are highly desired, as only a fraction of these…”
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Physiologic Preoperative Knee Hyperextension Is a Predictor of Failure in an Anterior Cruciate Ligament Revision Cohort: A Report From the MARS Group by Cooper, Daniel E., Dunn, Warren R., Huston, Laura J., Haas, Amanda K., Spindler, Kurt P., Allen, Christina R., Anderson, Allen F., DeBerardino, Thomas M., Lantz, Brett (Brick) A., Mann, Barton, Stuart, Michael J., Albright, John P., Amendola, Annunziato (Ned), Andrish, Jack T., Annunziata, Christopher C., Arciero, Robert A., Bach, Bernard R., Baker, Champ L., Bartolozzi, Arthur R., Baumgarten, Keith M., Bechler, Jeffery R., Berg, Jeffrey H., Bernas, Geoffrey A., Brockmeier, Stephen F., Brophy, Robert H., Bush-Joseph, Charles A., Butler V, J. Brad, Campbell, John D., Carey, James L., Carpenter, James E., Cole, Brian J., Cooper, Jonathan M., Cox, Charles L., Creighton, R. Alexander, Dahm, Diane L., David, Tal S., Flanigan, David C., Frederick, Robert W., Ganley, Theodore J., Garofoli, Elizabeth A., Gatt, Charles J., Gecha, Steven R., Giffin, James Robert, Hame, Sharon L., Hannafin, Jo A., Harner, Christopher D., Harris, Norman Lindsay, Hechtman, Keith S., Hershman, Elliott B., Hoellrich, Rudolf G., Hosea, Timothy M., Johnson, David C., Johnson, Timothy S., Jones, Morgan H., Kaeding, Christopher C., Kamath, Ganesh V., Klootwyk, Thomas E., Levy, Bruce A., Ma, C. Benjamin, Maiers, G. Peter, Marx, Robert G., Matava, Matthew J., Mathien, Gregory M., McAllister, David R., McCarty, Eric C., McCormack, Robert G., Miller, Bruce S., Nissen, Carl W., O’Neill, Daniel F., Owens, Brett D., Parker, Richard D., Purnell, Mark L., Ramappa, Arun J., Rauh, Michael A., Rettig, Arthur C., Sekiya, Jon K., Shea, Kevin G., Sherman, Orrin H., Slauterbeck, James R., Smith, Matthew V., Spang, Jeffrey T., Svoboda, Steven J., Taft, Timothy N., Tenuta, Joachim J., Tingstad, Edwin M., Vidal, Armando F., Viskontas, Darius G., White, Richard A., Williams, James S., Wolcott, Michelle L., Wolf, Brian R., York, James J., Wright, Rick W.

“…Background: The occurrence of physiologic knee hyperextension (HE) in the revision anterior cruciate ligament reconstruction (ACLR) population and its effect…”
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The role of intuition and reasoning in driving aversion to risk and ambiguity by Butler, Jeffrey V., Guiso, Luigi, Jappelli, Tullio

“…Using a large sample of retail investors as well as experimental data we find that risk and ambiguity aversion are positively correlated. We provide evidence…”
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Recurrence of group B streptococcal meningitis by Butler, V., Pejoan, H., Blot, N.

“…Group B Streptococcus is the most frequent cause of neonatal sepsis. However, recurrences are rare. We report a case of recurrent meningitis due to…”
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MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing by Vital, Tamara, Wali, Aminah, Butler, Kyle V, Xiong, Yan, Foster, 2nd, Joseph P, Marcel, Shelsa S, McFadden, Andrew W, Nguyen, Valerie U, Bailey, Benton M, Lamb, Kelsey N, James, Lindsey I, Frye, Stephen V, Mosely, Amber L, Jin, Jian, Pattenden, Samantha G, Davis, Ian J

“…Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1…”
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Identifying and prioritising the key components of a Quality Improvement Network for allied health professionals and psychological therapists: a group concept mapping project by Robinson, Lisa J, Butler, Hannah V, Hackett, Kate L

“…IntroductionDespite growing enthusiasm for quality improvement (QI), the complexities of modern healthcare continue to create gaps in our ability to…”
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Novel Inhibitors of Human Histone Deacetylase (HDAC) Identified by QSAR Modeling of Known Inhibitors, Virtual Screening, and Experimental Validation by Tang, Hao, Wang, Xiang S, Huang, Xi-Ping, Roth, Bryan L, Butler, Kyle V, Kozikowski, Alan P, Jung, Mira, Tropsha, Alexander

“…Inhibitors of histone deacetylases (HDACIs) have emerged as a new class of drugs for the treatment of human cancers and other diseases because of their effects…”
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Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome by Goldstone, A P, Holland, A J, Butler, J V, Whittington, J E

“…Objective: Prader–Willi syndrome (PWS) is a genetic neurodevelopmental disorder with several nutritional phases during childhood proceeding from poor feeding,…”
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Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity by Butler, Kyle V, Chiarella, Anna M, Jin, Jian, Hathaway, Nathaniel A

“…Epigenome editing is a powerful method for life science research and could give rise to new therapies for diseases initiated or maintained by epigenetic…”
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Imported chicken meat as a potential source of quinolone-resistant Escherichia coli producing extended-spectrum β-lactamases in the UK by Warren, R. E., Ensor, V. M., O'Neill, P., Butler, V., Taylor, J., Nye, K., Harvey, M., Livermore, D. M., Woodford, N., Hawkey, P. M.

“…Objectives Escherichia coli producing CTX-M-15 enzyme began to rapidly spread in the UK from around 2003 but other types also occur, notably CTX-M-14. We…”
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Second-Generation Histone Deacetylase 6 Inhibitors Enhance the Immunosuppressive Effects of Foxp3+ T-Regulatory Cells by Kalin, Jay H, Butler, Kyle V, Akimova, Tatiana, Hancock, Wayne W, Kozikowski, Alan P

“…Second-generation Tubastatin A analogues were synthesized and evaluated for their ability to inhibit selectively histone deacetylase 6 (HDAC6). Substitutions…”
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Rationale and Design of an Ecological Momentary Assessment Study Examining Predictors of Binge Eating Among Sexual Minority and Heterosexual Young Women: Protocol for the Health and Experiences in Real Life (HER Life) Study by Heron, Kristin E, Braitman, Abby L, Dawson, Charlotte A, Sandoval, Cassidy M, Butler, Lauren V, Moulder, Alicia, Lewis, Robin J

“…Previous research has identified health disparities between sexual minority and heterosexual women, including increased rates of obesity and binge eating in…”
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