Search Results - "Butler, Robert R."

Enhancement of Microbial Biodesulfurization via Genetic Engineering and Adaptive Evolution by Wang, Jia, Butler, 3rd, Robert R, Wu, Fan, Pombert, Jean-François, Kilbane, 2nd, John J, Stark, Benjamin C

“…In previous work from our laboratories a synthetic gene encoding a peptide ("Sulpeptide 1" or "S1") with a high proportion of methionine and cysteine residues…”
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Comparative Analysis of Codon Usage Bias Patterns in Microsporidian Genomes by Xiang, Heng, Zhang, Ruizhi, Butler, 3rd, Robert R, Liu, Tie, Zhang, Li, Pombert, Jean-François, Zhou, Zeyang

“…The sub-3 Mbp genomes from microsporidian species of the Encephalitozoon genus are the smallest known among eukaryotes and paragons of genomic reduction and…”
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Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics by He, Zihuai, Le Guen, Yann, Liu, Linxi, Lee, Justin, Ma, Shiyang, Yang, Andrew C., Liu, Xiaoxia, Rutledge, Jarod, Losada, Patricia Moran, Song, Bowen, Belloy, Michael E., Butler, Robert R., Longo, Frank M., Tang, Hua, Mormino, Elizabeth C., Wyss-Coray, Tony, Greicius, Michael D., Ionita-Laza, Iuliana

“…Knockoff-based methods have become increasingly popular due to their enhanced power for locus discovery and their ability to prioritize putative causal…”
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Genetic and multi‐omic risk assessment of Alzheimer's disease implicates core associated biological domains by Cary, Gregory A., Wiley, Jesse C., Gockley, Jake, Keegan, Stephen, Amirtha Ganesh, Sai Sruthi, Heath, Laura, Butler, Robert R., Mangravite, Lara M., Logsdon, Benjamin A., Longo, Frank M., Levey, Allan, Greenwood, Anna K., Carter, Gregory W.

“…INTRODUCTION Alzheimer's disease (AD) is the predominant dementia globally, with heterogeneous presentation and penetrance of clinical symptoms, variable…”
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GATA-3 dose-dependent checkpoints in early T cell commitment by Scripture-Adams, Deirdre D, Damle, Sagar S, Li, Long, Elihu, Koorosh J, Qin, Shuyang, Arias, Alexandra M, Butler, 3rd, Robert R, Champhekar, Ameya, Zhang, Jingli A, Rothenberg, Ellen V

“…GATA-3 expression is crucial for T cell development and peaks during commitment to the T cell lineage, midway through the CD4(-)CD8(-) (double-negative [DN])…”
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Sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypes by Kozlova, Alena, Butler, 3rd, Robert R, Zhang, Siwei, Ujas, Thomas, Zhang, Hanwen, Steidl, Stephan, Sanders, Alan R, Pang, Zhiping P, Vezina, Paul, Duan, Jubao

“…Repeated nicotine exposure leads to sensitization (SST) and enhances self-administration (SA) in rodents. However, the molecular basis of nicotine SST and SA…”
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Isolation and characterization of an interactive culture of two Paenibacillus species with moderately thermophilic desulfurization ability by Wang, Jia, Davaadelger, Batzaya, Salazar, Joelle K, Butler, Robert R., III, Pombert, Jean-François, Kilbane, John J, Stark, Benjamin C

“…OBJECTIVE: To isolate and characterize novel thermophilic bacteria capable of biodesulfurization of petroleum. RESULTS: A culture containing two Paenibacillus…”
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Clinotator: analyzing ClinVar variation reports to prioritize reclassification efforts by Butler Iii, Robert R, Gejman, Pablo V

“…While ClinVar has become an indispensable resource for clinical variant interpretation, its sophisticated structure provides it with a daunting learning curve…”
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Genetic Characterization of the Exceptionally High Heat Resistance of the Non-toxic Surrogate Clostridium sporogenes PA 3679 by Butler, 3rd, Robert R, Schill, Kristin M, Wang, Yun, Pombert, Jean-François

“…PA 3679 is a non-toxic endospore former that is widely used as a surrogate for by the food processing industry to validate thermal processing strategies. PA…”
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Genetic Diversity of Clostridium sporogenes PA 3679 Isolates Obtained from Different Sources as Resolved by Pulsed-Field Gel Electrophoresis and High-Throughput Sequencing by Schill, Kristin M, Wang, Yun, Butler, 3rd, Robert R, Pombert, Jean-François, Reddy, N Rukma, Skinner, Guy E, Larkin, John W

“…Clostridium sporogenes PA 3679 is a nonpathogenic, nontoxic model organism for proteolytic Clostridium botulinum used in the validation of conventional thermal…”
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Complete Genome Sequences of Two Human Oral Microbiome Commensals, Streptococcus salivarius ATCC 25975 and S. salivarius ATCC 27945 by Butler, 3rd, Robert R, Soomer-James, Jahna T A, Frenette, Michel, Pombert, Jean-François

“…strains are significant contributors to the human oral microbiome. Some possess unique fimbriae that give them the ability to coaggregate and colonize…”
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Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington’s Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31 by Simmons, Danielle A., Mills, Brian D., Butler III, Robert R., Kuan, Jason, McHugh, Tyne L. M., Akers, Carolyn, Zhou, James, Syriani, Wassim, Grouban, Maged, Zeineh, Michael, Longo, Frank M.

“…Huntington’s disease (HD) is caused by an expansion of the CAG repeat in the huntingtin gene leading to preferential neurodegeneration of the striatum…”
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Complete Genome Sequences of Two Interactive Moderate Thermophiles, Paenibacillus napthalenovorans 32O-Y and Paenibacillus sp. 32O-W by Butler, 3rd, Robert R, Wang, Jia, Stark, Benjamin C, Pombert, Jean-François

“…Microorganisms with the capability to desulfurize petroleum are in high demand with escalating restrictions currently placed on fuel purity. Thermophilic…”
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Clinotator: analyzing ClinVar variation reports to prioritize reclassification efforts [version 2; peer review: 2 approved] by Butler III, Robert R, Gejman, Pablo V

“…While ClinVar has become an indispensable resource for clinical variant interpretation, its sophisticated structure provides it with a daunting learning curve…”
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A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity‐dependent synaptic and microglial transcriptomic changes in a late‐stage Alzheimer's mouse model by Latif‐Hernandez, Amira, Yang, Tao, Butler, Robert R., Losada, Patricia Moran, Minhas, Paras S., White, Halle, Tran, Kevin C., Liu, Harry, Simmons, Danielle A., Langness, Vanessa, Andreasson, Katrin I., Wyss‐Coray, Tony, Longo, Frank M.

“…INTRODUCTION Tropomyosin related kinase B (TrkB) and C (TrkC) receptor signaling promotes synaptic plasticity and interacts with pathways affected by amyloid…”
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The Genetic Relevance of Human Induced Pluripotent Stem Cell-Derived Microglia to Alzheimer’s Disease and Major Neuropsychiatric Disorders by Butler III, Robert R., Kozlova, Alena, Zhang, Hanwen, Zhang, Siwei, Streit, Michael, Sanders, Alan R., Laudanski, Krzysztof, Pang, Zhiping P., Gejman, Pablo V., Duan, Jubao

“…Microglia are the primary innate immune cell type in the brain that have been implicated in the pathogenesis of several neurodegenerative and neuropsychiatric…”
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Network Understanding of Genetic Interplay Between Alzheimer’s Disease Endophenotypes by Keegan, Stephen, Cary, Gregory A., Wiley, Jesse C, Gockley, Jake, Leal, Karina, Butler, Robert R., Greenwood, Anna K, Carter, Gregory W

“…Background Alzheimer’s disease (AD) therapeutics have largely been unsuccessful in alleviating disease burden in those afflicted by the disease. The TREAT‐AD…”
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Modulation of the p75 neurotrophin receptor in the PS19 tauopathy mouse model regulates transcription profiles and inter‐cellular communication across multiple populations of non‐neuronal cells by III, Robert R. Butler, Yang, Tao, Han, Crystal, Guen, Yann Le, Tran, Kevin C, Lallani, Shoeb, Liu, Harry, Leng, Song Albert, Massa, Stephen M., Longo, Frank M.

“…Background Tau pathologies contribute to neurodegeneration in Alzheimer’s Disease (AD) and other disorders via a variety of mechanisms. In tauopathy mouse…”
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Microglial state changes in response to LM11A‐31 promote recovery in a tauopathy mouse model of Alzheimer’s Disease by Butler, Robert R., Yang, Tao, Tran, Kevin C, Johnson, William A, Liu, Harry, Leng, Song Albert, Massa, Stephen M., Longo, Frank M.

“…Background Tau pathologies in Alzheimer’s Disease (AD) contribute to neurodegeneration and synaptic degeneration via a variety of mechanisms. Neurotrophic…”
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p75 NTR modulation counteracts alterations in neuronal and glial activity‐dependent profiles of gene co‐expression networks in tauopathy mice by Latif‐Hernandez, Amira, Moran‐Losada, Patricia, Yang, Tao, III, Robert R. Butler, Tran, Kevin C, Liu, Harry, Massa, Stephen M., Wyss‐Coray, Tony, Longo, Frank M.

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