Search Results - "Butler, Jason M."

Angiocrine functions of organ-specific endothelial cells by Rafii, Shahin, Butler, Jason M., Ding, Bi-Sen

“…Endothelial cells that line capillaries are not just passive conduits for delivering blood. Tissue-specific endothelium establishes specialized vascular niches…”
Get full text

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration by Nolan, Daniel J., Ginsberg, Michael, Israely, Edo, Palikuqi, Brisa, Poulos, Michael G., James, Daylon, Ding, Bi-Sen, Schachterle, William, Liu, Ying, Rosenwaks, Zev, Butler, Jason M., Xiang, Jenny, Rafii, Arash, Shido, Koji, Rabbany, Sina Y., Elemento, Olivier, Rafii, Shahin

“…Microvascular endothelial cells (ECs) within different tissues are endowed with distinct but as yet unrecognized structural, phenotypic, and functional…”
Get full text

The bone marrow microenvironment at single-cell resolution by Tikhonova, Anastasia N., Dolgalev, Igor, Hu, Hai, Sivaraj, Kishor K., Hoxha, Edlira, Cuesta-Domínguez, Álvaro, Pinho, Sandra, Akhmetzyanova, Ilseyar, Gao, Jie, Witkowski, Matthew, Guillamot, Maria, Gutkin, Michael C., Zhang, Yutong, Marier, Christian, Diefenbach, Catherine, Kousteni, Stavroula, Heguy, Adriana, Zhong, Hua, Fooksman, David R., Butler, Jason M., Economides, Aris, Frenette, Paul S., Adams, Ralf H., Satija, Rahul, Tsirigos, Aristotelis, Aifantis, Iannis

“…The bone marrow microenvironment has a key role in regulating haematopoiesis, but its molecular complexity and response to stress are incompletely understood…”
Get full text

Conversion of adult endothelium to immunocompetent haematopoietic stem cells by Lis, Raphael, Karrasch, Charles C., Poulos, Michael G., Kunar, Balvir, Redmond, David, Duran, Jose G. Barcia, Badwe, Chaitanya R., Schachterle, William, Ginsberg, Michael, Xiang, Jenny, Tabrizi, Arash Rafii, Shido, Koji, Rosenwaks, Zev, Elemento, Olivier, Speck, Nancy A., Butler, Jason M., Scandura, Joseph M., Rafii, Shahin

“…Developmental pathways that orchestrate the fleeting transition of endothelial cells into haematopoietic stem cells remain undefined. Here we demonstrate a…”
Get full text

Distinct bone marrow blood vessels differentially regulate haematopoiesis by Itkin, Tomer, Gur-Cohen, Shiri, Spencer, Joel A., Schajnovitz, Amir, Ramasamy, Saravana K., Kusumbe, Anjali P., Ledergor, Guy, Jung, Yookyung, Milo, Idan, Poulos, Michael G., Kalinkovich, Alexander, Ludin, Aya, Golan, Karin, Khatib, Eman, Kumari, Anju, Kollet, Orit, Shakhar, Guy, Butler, Jason M., Rafii, Shahin, Adams, Ralf H., Scadden, David T., Lin, Charles P., Lapidot, Tsvee

“…Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both leukocyte trafficking and haematopoietic stem and progenitor cell…”
Get full text

Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance by Cao, Zhongwei, Ding, Bi-Sen, Guo, Peipei, Lee, Sharrell B., Butler, Jason M., Casey, Stephanie C., Simons, Michael, Tam, Wayne, Felsher, Dean W., Shido, Koji, Rafii, Arash, Scandura, Joseph M., Rafii, Shahin

“…Tumor endothelial cells (ECs) promote cancer progression in ways beyond their role as conduits supporting metabolism. However, it is unknown how vascular…”
Get full text

Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGFβ Suppression by Ginsberg, Michael, James, Daylon, Ding, Bi-Sen, Nolan, Daniel, Geng, Fuqiang, Butler, Jason M., Schachterle, William, Pulijaal, Venkat R., Mathew, Susan, Chasen, Stephen T., Xiang, Jenny, Rosenwaks, Zev, Shido, Koji, Elemento, Olivier, Rabbany, Sina Y., Rafii, Shahin

“…ETS transcription factors ETV2, FLI1, and ERG1 specify pluripotent stem cells into induced vascular endothelial cells (iVECs). However, iVECs are unstable and…”
Get full text

Endothelial transplantation rejuvenates aged hematopoietic stem cell function by Poulos, Michael G, Ramalingam, Pradeep, Gutkin, Michael C, Llanos, Pierre, Gilleran, Katherine, Rabbany, Sina Y, Butler, Jason M

“…Age-related changes in the hematopoietic compartment are primarily attributed to cell-intrinsic alterations in hematopoietic stem cells (HSCs); however, the…”
Get full text

Reprogramming human endothelial cells to haematopoietic cells requires vascular induction by Sandler, Vladislav M., Lis, Raphael, Liu, Ying, Kedem, Alon, James, Daylon, Elemento, Olivier, Butler, Jason M., Scandura, Joseph M., Rafii, Shahin

“…Generating engraftable human haematopoietic cells from autologous tissues is a potential route to new therapies for blood diseases. However, directed…”
Get full text

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration by Sato, Thomas N, James, Daylon, Mittal, Vivek, Butler, Jason M, Lyden, David, Rafii, Shahin, Shido, Koji, Kobayashi, Hideki, Nolan, Daniel J, Rosenwaks, Zev, Rabbany, Sina Y, Ding, Bi-Sen, Babazadeh, Alexander O

“…During embryogenesis, endothelial cells induce organogenesis before the development of circulation. These findings suggest that endothelial cells not only form…”
Get full text

Inducible nitric oxide synthase in neutrophils and endothelium contributes to ischemic brain injury in mice by Garcia-Bonilla, Lidia, Moore, Jamie M, Racchumi, Gianfranco, Zhou, Ping, Butler, Jason M, Iadecola, Costantino, Anrather, Josef

“…NO produced by inducible NO synthase (iNOS) contributes to ischemic brain injury, but the cell types expressing iNOS and mediating tissue damage have not been…”
Get full text

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis by Poulos, Michael G., Guo, Peipei, Kofler, Natalie M., Pinho, Sandra, Gutkin, Michael C., Tikhonova, Anastasia, Aifantis, Iannis, Frenette, Paul S., Kitajewski, Jan, Rafii, Shahin, Butler, Jason M.

“…The bone marrow (BM) microenvironment is composed of multiple niche cells that, by producing paracrine factors, maintain and regenerate the hematopoietic stem…”
Get full text

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells by Butler, Jason M, Chiu, Vi K, Benjamin, Laura, Rafii, Shahin, Bonner, Bryant, Nolan, Daniel J, Kobayashi, Mariko, Ding, Bi-Sen, O'Donnell, Rebekah, Shido, Koji, Kobayashi, Hideki

“…Endothelial cells form a vascular niche that supports haematopoietic stem cell function. Akt activation in endothelial cells upregulates angiocrine factors to…”
Get full text

Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response by Ramalingam, Pradeep, Gutkin, Michael C., Poulos, Michael G., Tillery, Taylor, Doughty, Chelsea, Winiarski, Agatha, Freire, Ana G., Rafii, Shahin, Redmond, David, Butler, Jason M.

“…Aging associated defects within stem cell-supportive niches contribute towards age-related decline in stem cell activity. However, mechanisms underlying…”
Get full text

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells by Butler, Jason M., Nolan, Daniel J., Vertes, Eva L., Varnum-Finney, Barbara, Kobayashi, Hideki, Hooper, Andrea T., Seandel, Marco, Shido, Koji, White, Ian A., Kobayashi, Mariko, Witte, Larry, May, Chad, Shawber, Carrie, Kimura, Yuki, Kitajewski, Jan, Rosenwaks, Zev, Bernstein, Irwin D., Rafii, Shahin

“…Bone marrow endothelial cells (ECs) are essential for reconstitution of hematopoiesis, but their role in self-renewal of long-term hematopoietic stem cells…”
Get full text

Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF by Ramalingam, Pradeep, Poulos, Michael G., Lazzari, Elisa, Gutkin, Michael C., Lopez, David, Kloss, Christopher C., Crowley, Michael J., Katsnelson, Lizabeth, Freire, Ana G., Greenblatt, Matthew B., Park, Christopher Y., Butler, Jason M.

“…Inflammatory signals arising from the microenvironment have emerged as critical regulators of hematopoietic stem cell (HSC) function during diverse processes…”
Get full text

Regulation of the hematopoietic stem cell lifecycle by the endothelial niche by Ramalingam, Pradeep, Poulos, Michael G, Butler, Jason M

“…Hematopoietic stem cells (HSCs) predominantly reside either in direct contact or in close proximity to the vascular endothelium throughout their lifespan. From…”
Get full text

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells by Hooper, Andrea T., Butler, Jason M., Nolan, Daniel J., Kranz, Andrea, Iida, Kaoruko, Kobayashi, Mariko, Kopp, Hans-Georg, Shido, Koji, Petit, Isabelle, Yanger, Kilangsungla, James, Daylon, Witte, Larry, Zhu, Zhenping, Wu, Yan, Pytowski, Bronislaw, Rosenwaks, Zev, Mittal, Vivek, Sato, Thomas N., Rafii, Shahin

“…Myelosuppression damages the bone marrow (BM) vascular niche, but it is unclear how regeneration of bone marrow vessels contributes to engraftment of…”
Get full text

Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics by Hadland, Brandon, Varnum-Finney, Barbara, Dozono, Stacey, Dignum, Tessa, Nourigat-McKay, Cynthia, Heck, Adam M., Ishida, Takashi, Jackson, Dana L., Itkin, Tomer, Butler, Jason M., Rafii, Shahin, Trapnell, Cole, Bernstein, Irwin D.

“…Hematopoietic stem cells (HSCs) develop from hemogenic endothelium within embryonic arterial vessels such as the aorta of the aorta-gonad-mesonephros region…”
Get full text

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells by Gori, Jennifer L, Butler, Jason M, Chan, Yan-Yi, Chandrasekaran, Devikha, Poulos, Michael G, Ginsberg, Michael, Nolan, Daniel J, Elemento, Olivier, Wood, Brent L, Adair, Jennifer E, Rafii, Shahin, Kiem, Hans-Peter

“…Pluripotent stem cells (PSCs) represent an alternative hematopoietic stem cell (HSC) source for treating hematopoietic disease. The limited engraftment of…”
Get full text