Search Results - "Butler, Donald E"

Lithiation of substituted pyrazoles. Synthesis of isomerically pure 1,3-, 1,3,5-, and 1,5-substituted pyrazoles by Butler, Donald E, Alexander, Susan M

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Amnesia-reversal activity of a series of cyclic imides by Butler, Donald E, Leonard, James D, Caprathe, Bradley W, L'Italien, Yvon J, Pavia, Michael R, Hershenson, Fred M, Poschel, Paul H, Marriott, John G

“…A series of dihydro-1H-pyrrolizine-3,5(2H,6H)-diones were synthesized and evaluated for their ability to reverse electroconvulsive shock (ECS) induced amnesia…”
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Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl]-2-oxo-1-pyrrolidineacetamides, including pramiracetam by Butler, Donald E, Nordin, Ivan C, L'Italien, Yvon J, Zweisler, Lynette, Poschel, Paul H, Marriott, John G

“…A series of N-[(dialkylamino)alkyl]-2-oxo-1- pyrrolidineacetamides was synthesized. The title compounds reversed electroconvulsive shock (ECS) induced amnesia…”
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3-Phenoxypyridine 1-oxides as anticonvulsant agents by Pavia, Michael R, Taylor, Charles P, Hershenson, Fred M, Lobbestael, Sandra J, Butler, Donald E

“…The anticonvulsant activity of a series of 3-phenoxypyridine 1-oxides is described. An investigation carried out to optimize the activity/side effect ratio…”
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Cognition-activating properties of 3-(aryloxy)pyridines by Butler, Donald E, Poschel, B. P. H, Marriott, John G

“…A series of 3-(aryloxy)pyridines was found to possess activity in enhancing retention for passive avoidance learning in mice. This test was used to select…”
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Pyrazolodiazepines. 2. 4-Aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1H)-ones as antianxiety and anticonvulsant agents by DeWald, Horace A, Lobbestael, Sandra, Butler, Donald E

“…A series of 4-aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e] [1,4]diazepin-7(1H)-ones was synthesized and screened for psychotropic activity. In animals, a number…”
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(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones. A series of novel potential antipsychotic agents by Wise, Lawrence D, Butler, Donald E, DeWald, Horace A, Lustgarten, David, Coughenour, Linda L, Downs, David A, Heffner, Thomas G, Pugsley, Thomas A

“…(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanone (1) was found to have an antipsychotic-like profile in behavioral tests predictive of…”
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(1,3-Dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones. A series of novel central nervous system depressants by Butler, Donald E, Wise, Lawrence D, DeWald, Horace A

“…A series of novel (1,3-dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones was synthesized. Pharmacological evaluation of these compounds demonstrated central…”
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Interpretation of Bone Scans by Butler, Donald E, Brucer, Marshall

“…An informal survey of nonacademic nuclear medicine laboratories indicates that about three fourths do bone scans; most do only a few, but some do more than 50…”
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N-Dealkylation of pyrazoles using pyridine hydrochloride by Butler, Donald E, DeWald, Horace A

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Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8-triazaspiro[4.5]decan-4-ones as potential antipsychotic agents by Wise, Lawrence D, Pattison, Ian C, Butler, Donald E, DeWald, Horace A, Lewis, Edward P, Lobbestael, Sandra J, Tecle, Haile, Coughenour, Linda L, Downs, David A, Poschel, B. P. H

“…8-[3-[Bis(4-fluorophenyl)amino]propyl]-1-phenyl-1,3,8- triazaspiro[4.5]decan-4-one (3) and related compounds have been shown to have antipsychotic profiles in…”
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1,3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents by Wise, Lawrence D, Butler, Donald E, DeWald, Horace A, Lustgarten, David M, Pattison, Ian C, Schweiss, Dieter N, Coughenour, Linda L, Downs, David A, Heffner, Thomas G, Pugsley, Thomas A

“…2-(Diethylamino)-N-[4-(2-fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl] acetamide (1) was recently found to have an antipsychotic-like profile in behavioral…”
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1-[3-(Diarylamino)propyl]piperidines and Related Compounds, Potential Antipsychotic Agents with Low Cataleptogenic Profiles by Wise, Lawrence D, Pattison, Ian C, Butler, Donald E, DeWald, Horace A, Lewis, Edward P, Lobbestael, Sandra J, Nordin, Ivan C, Poschel, B. P. H, Coughenour, Linda L

“…On the basis of a structural model of the postsynaptic dopaminergic antagonist pharmacophore, a series of 1-[3-(diarylamino)propyl]piperidines and related…”
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Novel pharmacological activity of a series of substituted pyridines by Butler, Donald E, Bass, Paul, Nordin, Ivan C, Hauck, Frederick P, L'Italien, Yvon J

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Synthetic antidiarrheal agents. 1. Approach to the separation of antidiarrheal activity from narcotic analgesic activity by Butler, Donald E, Meyer, Robert F, Alexander, Susan M, Bass, Paul, Kennedy, John A

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Synthesis of 1-methyl-1-(substituted benzyl)hydrazines by Butler, Donald E, Alexander, Susan M, McLean, John W, Strand, Linda B

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Atorvastatin, an HMG-COA reductase inhibitor and efficient lipid-regulating agent. Part I. Synthesis of ring-labeled [14C6]atorvastatin by Woo, Peter W. K., Hartman, Jon, Huang, Yun, Nanninga, Thomas, Bauman, Kelvin, Butler, Donald E., Rubin, John R., Lee, Helen T., Huang, Che C.

“…Pyrrole‐ring labeled [14C]atorvastatin (Lipitor®, CI‐981),…”
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The synthesis of medium-sized cyclic lactams by the intramolecular friedel-crafts cyclization of isocyanates. Formation of novel pyrazolo[3,4-c]benzolactams by Butler, Donald E., Alexander, Susan M.

“…A series of 4‐ω‐phenylalkyl substituted‐1H‐pyrazol‐5‐amines has been synthesized from the corresponding α‐acetylphenylalkanenitriles and methylhydrazine. They…”
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