Search Results - "Butler, C S"
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Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets
Published in PLoS pathogens (01-10-2016)“…Tissue damage is usually regarded as a necessary price to pay for successful elimination of pathogens by the innate immune defense. Yet, it is possible to…”
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Transcriptional profiling links unique human macrophage phenotypes to the growth of intracellular Salmonella enterica serovar Typhi
Published in Scientific reports (04-06-2024)“…Macrophages provide a crucial environment for Salmonella enterica serovar Typhi ( S. Typhi) to multiply during typhoid fever, yet our understanding of how…”
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3
Fimbriae reprogram host gene expression - Divergent effects of P and type 1 fimbriae
Published in PLoS pathogens (01-06-2019)“…Pathogens rely on a complex virulence gene repertoire to successfully attack their hosts. We were therefore surprised to find that a single fimbrial gene…”
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Therapeutic Effects of IL-1RA against Acute Bacterial Infections, including Antibiotic-Resistant Strains
Published in Pathogens (Basel) (01-01-2024)“…Innate immunity is essential for the anti-microbial defense, but excessive immune activation may cause severe disease. In this study, immunotherapy was shown…”
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Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex
Published in Nature communications (08-06-2021)“…Partially unfolded alpha-lactalbumin forms the oleic acid complex HAMLET, with potent tumoricidal activity. Here we define a peptide-based molecular approach…”
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A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer
Published in Nature biotechnology (01-06-2021)“…Is the oncogene MYC upregulated or hyperactive? In the majority of human cancers, finding agents that target c-MYC has proved difficult. Here we report…”
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Is the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) effective for preterm infants with intrauterine growth restriction?
Published in Journal of perinatology (01-02-2011)“…Objective: This study investigates the effectiveness of the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) on neurobehavioral and…”
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8
Evolution of the soluble nitrate reductase: defining the monomeric periplasmic nitrate reductase subgroup
Published in Biochemical Society transactions (01-02-2006)“…Bacterial nitrate reductases can be classified into at least three groups according to their localization and function, namely membrane-bound (NAR) or…”
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9
Heat-flux measurements on a hypersonic inlet ramp using fast-response temperature-sensitive paint
Published in Experiments in fluids (01-04-2019)“…Global heat-flux measurements are performed using a newly developed temperature-sensitive paint (TSP) on an inclined ramp with sidewalls in a hypersonic shock…”
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10
NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restriction
Published in Journal of perinatology (01-10-2012)“…Objective: The effect of NIDCAP (Newborn Individualized Developmental Care and Assessment Program) was examined on the neurobehavioral, electrophysiological…”
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The emerging molecular structure of the nitrogen cycle: an introduction to the proceedings of the 10th annual N-cycle meeting
Published in Biochemical Society transactions (01-02-2005)“…Over the last 10 years, during the lifetime of the nitrogen cycle meetings, structural biology, coupled with spectroscopy, has had a major impact of our…”
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12
Delayed pneumothorax and hydrothorax with central venous catheter migration
Published in Anaesthesia (01-10-1999)“…We report a case of delayed pneumothorax, central venous catheter migration and iatrogenic hydrothorax in a 22‐year‐old female. The left subclavian central…”
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Severe hyponatraemia secondary to desmopressin therapy in von Willebrand's disease
Published in Anaesthesia and intensive care (01-04-2000)“…A 42-year-old female with von Willebrand's disease was managed with desmopressin and tranexamic acid to aid haemostasis following a vaginal hysterectomy…”
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Developing structure-based models to predict substrate specificity of D-group (Type II) molybdenum enzymes: application to a molybdo-enzyme of unknown function from Archaeoglobus fulgidus
Published in Biochemical Society transactions (01-02-2006)“…The AF0174-AF0176 gene cluster in Archaeoglobus fulgidus encodes a putative oxyanion reductase of the D-type (Type II) family of molybdo-enzymes. Sequence…”
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Microbial reduction of selenate and nitrate: common themes and variations
Published in Biochemical Society transactions (01-02-2005)“…A number of biochemically distinct systems have been characterized for the microbial reduction of the oxyanions, selenate (SeO(4)(2-)) and nitrate (NO(3)(-))…”
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One species, different diseases: the unique molecular mechanisms that underlie the pathogenesis of typhoidal Salmonella infections
Published in Current opinion in microbiology (01-04-2023)“…Salmonella enterica is one of the most widespread bacterial pathogens found worldwide, resulting in approximately 100 million infections and over 200 000…”
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Purification and characterization of cytochrome c' from Neisseria meningitidis
Published in Biochemical Society transactions (01-02-2005)“…Cytochrome c', a c-type cytochrome with unique spectroscopic and magnetic properties, has been characterized in a variety of denitrifying and photosynthetic…”
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Thiocyanate binding to the molybdenum centre of the periplasmic nitrate reductase from Paracoccus pantotrophus
Published in Biochemical journal (15-12-2000)“…The periplasmic nitrate reductase (NAP) from Paracoccus pantotrophus is a soluble two-subunit enzyme (NapAB) that binds two haem groups, a [4Fe-4S] cluster and…”
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Structure and Function: A Guide to Three Major Structural-Functional Theories
Published 2003“…Like its companion volume, this book offers a detailed description and comparison of three major structural-functional theories: Functional Grammar, Role and…”
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Plasma lignocaine concentration following nebulization for awake intubation
Published in Anaesthesia and intensive care (01-08-1997)“…Nebulization of lignocaine is a common technique for preparing the airway prior to awake intubation. The aim of the study was to assay the serum levels of…”
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