Search Results - "Butcher, Donna O."

Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Rα by Chen, Jing, Feigenbaum, Lionel, Awasthi, Parirokh, Butcher, Donna O., Anver, Miriam R., Golubeva, Yelena G., Bamford, Richard, Zhang, Xiaojie, St. Claire, Mark B., Thomas, Craig J., Discepolo, Valentina, Jabri, Bana, Waldmann, Thomas A.

“…Increased serum levels of IL-15 are reported in type 1 diabetes (T1D). Here we report elevated serum soluble IL-15Rα levels in human T1D. To investigate the…”
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Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies by Dave, Hema, Anver, Miriam R, Butcher, Donna O, Brown, Patrick, Khan, Javed, Wayne, Alan S, Baskar, Sivasubramanian, Rader, Christoph

“…Despite high cure rates for pediatric B-lineage acute lymphoblastic leukemia (B-ALL), short-term and long-term toxicities and chemoresistance are shortcomings…”
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Gene expression profiling of alveolar soft-part sarcoma (ASPS) by Stockwin, Luke H, Vistica, David T, Kenney, Susan, Schrump, David S, Butcher, Donna O, Raffeld, Mark, Shoemaker, Robert H

“…Alveolar soft-part sarcoma (ASPS) is an extremely rare, highly vascular soft tissue sarcoma affecting predominantly adolescents and young adults. In an attempt…”
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Therapeutic vulnerability of an in vivo model of alveolar soft part sarcoma (ASPS) to antiangiogenic therapy by Vistica, David T, Hollingshead, Melinda, Borgel, Suzanne D, Kenney, Susan, Stockwin, Luke H, Raffeld, Mark, Schrump, David S, Burkett, Sandra, Stone, Gary, Butcher, Donna O, Shoemaker, Robert H

“…In vivo growth of alveolar soft part sarcoma (ASPS) was achieved using subcutaneous xenografts in sex-matched nonobese diabetic severe combined…”
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Naturally Acquired Mouse Kidney Parvovirus Infection Produces a Persistent Interstitial Nephritis in Immunocompetent Laboratory Mice by Edmondson, Elijah F., Hsieh, Wang-Ting, Kramer, Josh A., Breed, Matthew W., Roelke-Parker, Melody E., Stephens-Devalle, Julie, Pate, Nathan M., Bassel, Laura L., Hollingshead, Melinda G., Karim, Baktiar O., Butcher, Donna O., Warner, Andrew C., Nagashima, Kunio, Gulani, Jatinder

“…Mouse kidney parvovirus (MKPV), also known as murine chapparvovirus (MuCPV), is an emerging, highly infectious agent that has been isolated from laboratory and…”
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Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15R[alpha] by Chen, Jing, Feigenbaum, Lionel, Awasthi, Parirokh, Butcher, Donna O, Anver, Miriam R, Golubeva, Yelena G, Bamford, Richard, Zhang, Xiaojie, St Claire, Mark B, Thomas, Craig J, Discepolo, Valentina, Jabri, Bana, Waldmann, Thomas A

“…Increased serum levels of IL-15 are reported in type 1 diabetes (T1D). Here we report elevated serum soluble IL-15Rα levels in human T1D. To investigate the…”
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Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccines by Li, Qian, Anver, Miriam R, Butcher, Donna O, Gildersleeve, Jeffrey C

“…The tumor-associated Tn antigen has been investigated extensively as a biomarker and therapeutic target. Cancer vaccines containing the Tn antigen as a single…”
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GalNAcα1‐3Gal, a new prognostic marker for cervical cancer by Li, Qian, Anver, Miriam R., Li, Zhitao, Butcher, Donna O., Gildersleeve, Jeffrey C.

“…Cancer cells undergo significant changes in carbohydrate expression, and these alterations can be useful as biomarkers and therapeutic targets. In this study,…”
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Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors by Ridnour, Lisa A, Cheng, Robert Ys, Kedei, Noemi, Somasundaram, Veena, Bhattacharyya, Dibyangana D, Basudhar, Debashree, Wink, Adelaide L, Walke, Abigail J, Kim, Caleb, Heinz, William F, Edmondson, Elijah F, Butcher, Donna O, Warner, Andrew C, Dorsey, Tiffany H, Pore, Milind, Kinders, Robert J, Lipkowitz, Stanley, Bryant, Richard J, Rittscher, Jens, Wong, Stephen Tc, Hewitt, Stephen M, Chang, Jenny C, Shalaby, Aliaa, Callagy, Grace M, Glynn, Sharon A, Ambs, Stefan, Anderson, Stephen K, McVicar, Daniel W, Lockett, Stephen J, Wink, David A

“…Immune therapy is the new frontier of cancer treatment. Therapeutic radiation is a known inducer of immune response and can be limited by immunosuppressive…”
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The Root Causes of Pharmacodynamic Assay Failure by Ferry-Galow, Katherine V., PhD, Makhlouf, Hala R., MD, PhD, Wilsker, Deborah F., PhD, Lawrence, Scott M, Pfister, Thomas D., PhD, Marrero, Allison M., PhD, Bigelow, Kristina M, Yutzy, William H, Ji, Jiuping J., PhD, Butcher, Donna O, Gouker, Brad A, Kummar, Shivaani, MD, Chen, Alice P., MD, Kinders, Robert J., PhD, Parchment, Ralph E., PhD, Doroshow, James H., MD

“…Robust pharmacodynamic assay results are valuable for informing go/no‐go decisions about continued development of new anti-cancer agents and for identifying…”
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ASPS-1, a novel cell line manifesting key features of alveolar soft part sarcoma by Kenney, Susan, Vistica, David T, Stockwin, Luke H, Burkett, Sandra, Hollingshead, Melinda G, Borgel, Suzanne D, Butcher, Donna O, Schrump, David S, Shoemaker, Robert H

“…In vitro growth of alveolar soft part sarcoma (ASPS) and establishment of an ASPS cell line, ASPS-1, are described in this study. Using a recently developed…”
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M1221 The Role of Substance P and Mast Cells as Immunohistologic Biomarkers for Chronic Abdominal Pain in Children by Henderson, Wendy A, Taylor, Tara J, Shankar, Ravi, Anver, Miriam R, Butcher, Donna O, Youssef, Nader N

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Abstract 5279: Establishing robust pharmacodynamic (PD) immunofluorescence assays of clinical biopsies at the National Cancer Institute: Optimized quality control procedures for the evaluation of DNA damage response and epithelial-mesenchymal transition (EMT) biomarkers by Ferry-Galow, Katherine V., Lawrence, Scott M., Navas, Tony, Makhlouf, Hala R., Butcher, Donna O., Gouker, Brad A., Yutzy, William H., Ji, Jiuping, Kinders, Robert, Parchment, Ralph E., Kummar, Shivaani, Tomaszewski, Joseph E., Doroshow, James H.

“…Robust PD assay results are valuable for informing decisions about continued preclinical and clinical development of new agents and for identifying effective…”
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Abstract LB-B18: Epithelial to mesenchymal transition in human tumor biopsies: Quantitative, histopathological proof of the existence of EMT in vivo by immunofluorescence microscopy by Navas, Tony, Kinders, Robert J., Lawrence, Scott M., Ferry-Galow, Katherine, Pfister, Thomas D., Srivastava, Apurva K., Alcoser, Sergio Y., Hollingshead, Melinda G., Dutko, Lindsay M., Gouker, Brad A., Butcher, Donna O., Makhlouf, Hala, Chuaqui, Rodrigo, Bottaro, Donald P., Kummar, Shivaani, Chen, Alice, Doroshow, James H., Parchment, Ralph E.

“…Epithelial-mesenchymal transition (EMT) is a dynamic process whereby epithelial cells acquire mesenchymal properties. Despite the clinical significance of the…”
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Abstract 1621: The proprotein convertase PCSK1 is a novel drug target in alveolar soft part sarcoma (ASPS) by Vistica, David T., Kenney, Susan, Scudiero, Dominic A., Reinhart, Russell A., Selby, Michael H., Butcher, Donna O., Shoemaker, Robert H.

“…Proprotein convertases (PCs) are a family of calcium-dependent serine endoproteases which mediate the proteolytic cleavage, at pairs of dibasic amino acids, of…”
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GalNAcalpha1-3Gal, a new prognostic marker for cervical cancer by Li, Qian, Anver, Miriam R, Li, Zhitao, Butcher, Donna O, Gildersleeve, Jeffrey C

“…Cancer cells undergo significant changes in carbohydrate expression, and these alterations can be useful as biomarkers and therapeutic targets. In this study,…”
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GalNAcα1-3Gal, a new prognostic marker for cervical cancer by QIAN LI, ANVER, Miriam R, ZHITAO LI, BUTCHER, Donna O, GILDERSTEEVE, Jeffrey C

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Therapeutic Vulnerability of an In Vivo Model of Alveolar Soft Part Sarcoma (ASPS) to Anti -Angiogenic Therapy by Vistica, David T., Hollingshead, Melinda, Borgel, Suzanne D., Kenney, Susan, Stockwin, Luke H., Raffeld, Mark, Schrump, David S., Burkett, Sandra, Stone, Gary, Butcher, Donna O., Shoemaker, Robert H.

“…In vivo growth of Alveolar Soft Part Sarcoma (ASPS) was achieved using subcutaneous xenografts in sex matched NOD.SCID\NCr mice. One tumor, currently at…”
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