Self-Assembled CNF/rGO/Tannin Composite: Study of the Physicochemical and Wound Healing Properties

Self-Assembled CNF/rGO/Tannin Composite: Study of the Physicochemical and Wound Healing Properties

In this study, a conductive composite material, based on graphene oxide (GO), nanocellulose (CNF), and tannins (TA) from pine bark, reduced using polydopamine (PDA), was developed for wound dressing. The amount of CNF and TA was varied in the composite material, and a complete characterization inclu...

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Bibliographic Details
Published in:Polymers Vol. 15; no. 12; p. 2752
Main Authors: Fernández, Katherina, Llanquileo, Aylen, Bustos, Monserrat, Aedo, Valentina, Ruiz, Isleidy, Carrasco, Sebastián, Tapia, Mauricio, Pereira, Miguel, Meléndrez, Manuel F, Aguayo, Claudio, Atanase, Leonard I
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-06-2023
MDPI
Subjects:
Biomedical materials
Care and treatment
Cellulose
Chemical composition
Composite materials
Enzymes
Ethanol
Graphene
graphene oxide
Graphite
Mechanical properties
nanocellulose
Pharmaceutical industry
Physiological aspects
Physiology
polydopamine
Polymerization
reduced graphene oxide
Self-assembly
Surface charge
Tannins
Thermodynamic properties
Toxicity
Wound healing
Wounds and injuries
X ray photoelectron spectroscopy
Chile
United States
Germany
graphene oxide
nanocellulose
wound healing
polydopamine
reduced graphene oxide
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Summary:In this study, a conductive composite material, based on graphene oxide (GO), nanocellulose (CNF), and tannins (TA) from pine bark, reduced using polydopamine (PDA), was developed for wound dressing. The amount of CNF and TA was varied in the composite material, and a complete characterization including SEM, FTIR, XRD, XPS, and TGA was performed. Additionally, the conductivity, mechanical properties, cytotoxicity, and in vitro wound healing of the materials were evaluated. A successful physical interaction between CNF, TA, and GO was achieved. Increasing CNF amount in the composite reduced the thermal properties, surface charge, and conductivity, but its strength, cytotoxicity, and wound healing performance were improved. The TA incorporation slightly reduced the cell viability and migration, which may be associated with the doses used and the extract's chemical composition. However, the in-vitro-obtained results demonstrated that these composite materials can be suitable for wound healing.
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ISSN:2073-4360
2073-4360
DOI:10.3390/polym15122752