Search Results - "Busto, Jon V."

Lateral plasma membrane compartmentalization links protein function and turnover by Busto, Jon V, Elting, Annegret, Haase, Daniel, Spira, Felix, Kuhlman, Julian, Schäfer‐Herte, Marco, Wedlich‐Söldner, Roland

“…Biological membranes organize their proteins and lipids into nano‐ and microscale patterns. In the yeast plasma membrane (PM), constituents segregate into a…”
Get full text

Biogenesis of mitochondrial β‐barrel membrane proteins by Ganesan, Iniyan, Busto, Jon V., Pfanner, Nikolaus, Wiedemann, Nils

“…β‐barrel membrane proteins in the mitochondrial outer membrane are crucial for mediating the metabolite exchange between the cytosol and the mitochondrial…”
Get full text

Binding of β-Amyloid (1–42) Peptide to Negatively Charged Phospholipid Membranes in the Liquid-Ordered State: Modeling and Experimental Studies by Ahyayauch, Hasna, Raab, Michal, Busto, Jon V., Andraka, Nagore, Arrondo, José-Luis R., Masserini, Massimo, Tvaroska, Igor, Goñi, Félix M.

“…To explore the initial stages of amyloid β peptide (Aβ42) deposition on membranes, we have studied the interaction of Aβ42 in the monomeric form with lipid…”
Get full text

Biophysical Properties of Novel 1-Deoxy-(Dihydro)ceramides Occurring in Mammalian Cells by Jiménez-Rojo, Noemi, Sot, Jesús, Busto, Jon V., Shaw, Walt A., Duan, Jingjing, Merrill, Alfred H., Alonso, Alicia, Goñi, Félix M.

“…Ceramides and dihydroceramides are N-acyl derivatives of sphingosine and sphinganine, respectively, which are the major sphingoid-base backbones of mammals…”
Get full text

Lamellar Gel (Lβ) Phases of Ternary Lipid Composition Containing Ceramide and Cholesterol by Busto, Jon V., García-Arribas, Aritz B., Sot, Jesús, Torrecillas, Alejandro, Gómez-Fernández, Juan C., Goñi, Félix M., Alonso, Alicia

“…Lipid lateral segregation into specific domains in cellular membranes is associated with cell signaling and metabolic regulation. This phenomenon partially…”
Get full text

N-Nervonoylsphingomyelin (C24:1) Prevents Lateral Heterogeneity in Cholesterol-Containing Membranes by Maté, Sabina, Busto, Jon V., García-Arribas, Aritz B., Sot, Jesús, Vazquez, Romina, Herlax, Vanesa, Wolf, Claude, Bakás, Laura, Goñi, Félix M.

“…This study was conducted to explore how the nature of the acyl chains of sphingomyelin (SM) influence its lateral distribution in the ternary lipid mixture…”
Get full text

Atomic Force Microscopy Characterization of Palmitoylceramide and Cholesterol Effects on Phospholipid Bilayers: A Topographic and Nanomechanical Study by García-Arribas, Aritz B, Busto, Jon V, Alonso, Alicia, Goñi, Félix M

“…Supported planar bilayers (SPBs) on mica substrates have been studied at 23 °C under atomic force microscopy (AFM)-based surface topography and force…”
Get full text

Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells by Ahyayauch, Hasna, García-Arribas, Aritz B., Sot, Jesús, González-Ramírez, Emilio J., Busto, Jon V., Monasterio, Bingen G., Jiménez-Rojo, Noemi, Contreras, F. Xabier, Rendón-Ramírez, Adela, Martin, Cesar, Alonso, Alicia, Goñi, Félix M.

“…The mechanisms of Pb(II) toxicity have been studied in human red blood cells using confocal microscopy, immunolabeling, fluorescence-activated cell sorting and…”
Get full text

Integration Through Separation - The Role of Lateral Membrane Segregation in Nutrient Uptake by Busto, Jon V, Wedlich-Söldner, Roland

“…Nutrient transporters are prominent and ubiquitous components of the plasma membrane in all cell types. Their expression and regulation are tightly linked to…”
Get full text

Solvation and Hydration of the Ceramide Headgroup in a Non-Polar Solution by Gillams, Richard J, Busto, Jon V, Busch, Sebastian, Goñi, Félix M, Lorenz, Christian D, McLain, Sylvia E

“…The microscopic hydration of the ceramide headgroup has been determined using a combination of experimentalboth NMR and neutron diffraction techniques and…”
Get full text

Cholesterol displacement by ceramide in sphingomyelin-containing liquid-ordered domains, and generation of gel regions in giant lipidic vesicles by Sot, Jesús, Ibarguren, Maitane, Busto, Jon V., Montes, L.-Ruth, Goñi, Félix M., Alonso, Alicia

“…Fluorescence confocal microscopy and differential scanning calorimetry are used in combination to study the phase behaviour of bilayers composed of…”
Get full text

Accumulated Bending Energy Elicits Neutral Sphingomyelinase Activity in Human Red Blood Cells by López, David J., Egido-Gabas, Meritxell, López-Montero, Iván, Busto, Jon V., Casas, Josefina, Garnier, Marie, Monroy, Francisco, Larijani, Banafshé, Goñi, Félix M., Alonso, Alicia

“…We propose that accumulated membrane bending energy elicits a neutral sphingomyelinase (SMase) activity in human erythrocytes. Membrane bending was achieved by…”
Get full text

Low pH Modulates the Macroorganization and Thermal Stability of PSII Supercomplexes in Grana Membranes by Stoichev, Svetozar, Krumova, Sashka B., Andreeva, Tonya, Busto, Jon V., Todinova, Svetla, Balashev, Konstantin, Busheva, Mira, Goñi, Félix M., Taneva, Stefka G.

“…Protonation of the lumen-exposed residues of some photosynthetic complexes in the grana membranes occurs under conditions of high light intensity and triggers…”
Get full text

Insights into Sphingolipid Miscibility: Separate Observation of Sphingomyelin and Ceramide N-Acyl Chain Melting by Leung, Sherry S.W., Busto, Jon V., Keyvanloo, Amir, Goñi, Félix M., Thewalt, Jenifer

“…Ceramide produced from sphingomyelin in the plasma membrane is purported to affect signaling through changes in the membrane’s physical properties. Thermal…”
Get full text

Cholesterol–Ceramide Interactions in Phospholipid and Sphingolipid Bilayers As Observed by Positron Annihilation Lifetime Spectroscopy and Molecular Dynamics Simulations by García-Arribas, Aritz B, Axpe, Eneko, Mujika, Jon Iñaki, Mérida, David, Busto, Jon V, Sot, Jesús, Alonso, Alicia, Lopez, Xabier, García, Jose Ángel, Ugalde, Jesus M, Plazaola, Fernando, Goñi, Félix M

“…Free volume voids in lipid bilayers can be measured by positron annihilation lifetime spectroscopy (PALS). This technique has been applied, together with…”
Get full text

Coexistence of Immiscible Mixtures of Palmitoylsphingomyelin and Palmitoylceramide in Monolayers and Bilayers by Busto, Jon V., Fanani, María Laura, De Tullio, Luisina, Sot, Jesús, Maggio, Bruno, Goñi, Félix M., Alonso, Alicia

“…A combination of lipid monolayer- and bilayer-based model systems has been applied to explore in detail the interactions between and organization of…”
Get full text

Membrane binding and insertion of the predicted transmembrane domain of human scramblase 1 by Posada, Itziar M.D., Busto, Jon V., Goñi, Félix M., Alonso, Alicia

“…Human phospholipid scramblase 1 (SCR) was originally described as an intrinsic membrane protein catalyzing transbilayer phospholipid transfer in the absence of…”
Get full text

Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells by Ugarte-Uribe, Begoña, Grijalvo, Santiago, Busto, Jon V., Martín, César, Eritja, Ramón, Goñi, Félix M., Alkorta, Itziar

“…The potential use of nucleic acids as therapeutic drugs has triggered the quest for oligonucleotide conjugates with enhanced cellular permeability. To this…”
Get full text

Mitochondrial sorting and assembly machinery operates by β-barrel switching by Takeda, Hironori, Tsutsumi, Akihisa, Nishizawa, Tomohiro, Lindau, Caroline, Busto, Jon V., Wenz, Lena-Sophie, Ellenrieder, Lars, Imai, Kenichiro, Straub, Sebastian P., Mossmann, Waltraut, Qiu, Jian, Yamamori, Yu, Tomii, Kentaro, Suzuki, Junko, Murata, Takeshi, Ogasawara, Satoshi, Nureki, Osamu, Becker, Thomas, Pfanner, Nikolaus, Wiedemann, Nils, Kikkawa, Masahide, Endo, Toshiya

“…The mitochondrial outer membrane contains so-called β-barrel proteins, which allow communication between the cytosol and the mitochondrial interior 1 – 3 …”
Get full text

A multipoint guidance mechanism for β-barrel folding on the SAM complex by Takeda, Hironori, Busto, Jon V., Lindau, Caroline, Tsutsumi, Akihisa, Tomii, Kentaro, Imai, Kenichiro, Yamamori, Yu, Hirokawa, Takatsugu, Motono, Chie, Ganesan, Iniyan, Wenz, Lena-Sophie, Becker, Thomas, Kikkawa, Masahide, Pfanner, Nikolaus, Wiedemann, Nils, Endo, Toshiya

“…Mitochondrial β-barrel proteins are essential for the transport of metabolites, ions and proteins. The sorting and assembly machinery (SAM) mediates their…”
Get full text