Search Results - "Bustelo, Xose R"

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas by Abate, Francesco, da Silva-Almeida, Ana C., Zairis, Sakellarios, Robles-Valero, Javier, Couronne, Lucile, Khiabanian, Hossein, Quinn, S. Aidan, Kim, Mi-Yeon, Laginestra, Maria Antonella, Kim, Christine, Fiore, Danilo, Bhagat, Govind, Piris, Miguel Angel, Campo, Elias, Lossos, Izidore S., Bernard, Olivier A., Inghirami, Giorgio, Pileri, Stefano, Bustelo, Xosé R., Rabadan, Raul, Ferrando, Adolfo A., Palomero, Teresa

“…Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas frequently associated with poor prognosis and for which genetic…”
Get full text

The 90S Preribosome Is a Multimodular Structure That Is Assembled through a Hierarchical Mechanism by Pérez-Fernández, Jorge, Román, Ángel, De Las Rivas, Javier, Bustelo, Xosé R., Dosil, Mercedes

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

CANCERTOOL: a visualization and representation interface to exploit cancer datasets by Cortazar, Ana R, Torrano, Veronica, Martín-Martín, Natalia, Caro-Maldonado, Alfredo, Camacho, Laura, Hermanova, Ivana, Guruceaga, Elizabeth, Lorenzo-Martín, Luis F, Caloto, Ruben, Gomis, Roger R, Apaolaza, Iñigo, Quesada, Víctor, Trka, Jan, Gomez-Muñoz, Antonio, Vicent, Silvestre, Bustelo, Xosé R, Planes, Francisco J, Aransay, Ana M, Carracedo, Arkaitz

“…With the advent of OMICs technologies, both individual research groups and consortia have spear-headed the characterization of human samples of multiple…”
Get full text

Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation by Castro-Castro, Antonio, Muriel, Olivia, Del Pozo, Miguel A, Bustelo, Xosé R

“…The Rac1 GTPase plays key roles in cytoskeletal organization, cell motility and a variety of physiological and disease-linked responses. Wild type Rac1…”
Get full text

Essential function for the GTPase TC21 in homeostatic antigen receptor signaling by Alarcón, Balbino, Cubelos, Beatriz, Bustelo, Xosé R, Mérida, Isabel, Calleja, Enrique, Ciprés, Angel, Delgado, Pilar, Martínez-Martín, Nuria, Bellas, Carmen

“…Tonic antigen receptor signaling contributes to the homeostasis of naive lymphocytes. Alarcón and colleagues show that resting lymphocytes transmit tonic…”
Get full text

The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis by Contador-Troca, María, Alvarez-Barrientos, Alberto, Barrasa, Eva, Rico-Leo, Eva M, Catalina-Fernández, Inmaculada, Menacho-Márquez, Mauricio, Bustelo, Xosé R, García-Borrón, José C, Gómez-Durán, Aurea, Sáenz-Santamaría, Javier, Fernández-Salguero, Pedro M

“…Melanoma is a highly metastatic and malignant skin cancer having poor rates of patient survival. Since the incidence of melanoma is steadily increasing in the…”
Get full text

Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking by Zhu, Shuyong, Zhao, Chengjiang, Wu, Yingying, Yang, Qiaoqiao, Shao, Aiyun, Wang, Tiepeng, Wu, Jianfu, Yin, Yanqing, Li, Yandong, Hou, Jincan, Zhang, Xinhua, Zhou, Guomin, Gu, Xiaosong, Wang, Xiaomin, Bustelo, Xosé R, Zhou, Jiawei

“…The molecular mechanisms underlying the regulation of dopamine transporter activity in the brain remain poorly understood. The authors show that glial cell…”
Get full text

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops by Menacho-Márquez, Mauricio, García-Escudero, Ramón, Ojeda, Virginia, Abad, Antonio, Delgado, Pilar, Costa, Clotilde, Ruiz, Sergio, Alarcón, Balbino, Paramio, Jesús M, Bustelo, Xosé R

“…The catalytic activity of GDP/GTP exchange factors (GEFs) is considered critical to maintain the typically high activity of Rho GTPases found in cancer cells…”
Get full text

Azathioprine Suppresses Ezrin-Radixin-Moesin-Dependent T Cell-APC Conjugation through Inhibition of Vav Guanosine Exchange Activity on Rac Proteins by Poppe, Daniela, Tiede, Imke, Fritz, Gerhard, Becker, Christoph, Bartsch, Brigitte, Wirtz, Stefan, Strand, Dennis, Tanaka, Shinya, Galle, Peter R, Bustelo, Xose R, Neurath, Markus F

“…We have shown recently that the azathioprine metabolite 6-Thio-GTP causes immunosuppression by blockade of GTPase activation in T lymphocytes. In the present…”
Get full text

RasGRF2, a Guanosine Nucleotide Exchange Factor for Ras GTPases, Participates in T-Cell Signaling Responses by Ruiz, Sergio, Santos, Eugenio, Bustelo, Xosé R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells by Sauzeau, Vincent, Sevilla, María A, Montero, María J, Bustelo, Xosé R

“…The regulation of arterial contractility is essential for blood pressure control. The GTPase RhoA promotes vasoconstriction by modulating the cytoskeleton of…”
Get full text

A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition by Schuhmacher, Alberto J, Guerra, Carmen, Sauzeau, Vincent, Cañamero, Marta, Bustelo, Xosé R, Barbacid, Mariano

“…Germline activation of H-RAS oncogenes is the primary cause of Costello syndrome (CS), a neuro-cardio-facio-cutaneous developmental syndrome. Here we describe…”
Get full text

Transcriptional Factor Aryl Hydrocarbon Receptor (Ahr) Controls Cardiovascular and Respiratory Functions by Regulating the Expression of the Vav3 Proto-oncogene by Sauzeau, Vincent, Carvajal-González, José M., Riolobos, Adelaida S., Sevilla, María A., Menacho-Márquez, Mauricio, Román, Ángel C., Abad, Antonio, Montero, María J., Fernández-Salguero, Pedro, Bustelo, Xosé R.

“…Aryl hydrocarbon receptor (Ahr) is a transcriptional factor involved in detoxification responses to pollutants and in intrinsic biological processes of…”
Get full text

Genetic Dissection of the Vav2-Rac1 Signaling Axis in Vascular Smooth Muscle Cells by Fabbiano, Salvatore, Menacho-Márquez, Mauricio, Sevilla, María A., Albarrán-Juárez, Julián, Zheng, Yi, Offermanns, Stefan, Montero, María J., Bustelo, Xosé R.

“…Vascular smooth muscle cells (vSMCs) are key in the regulation of blood pressure and the engagement of vascular pathologies, such as hypertension, arterial…”
Get full text

Vav3-deficient mice exhibit a transient delay in cerebellar development by Quevedo, Celia, Sauzeau, Vincent, Menacho-Márquez, Mauricio, Castro-Castro, Antonio, Bustelo, Xosé R

“…Vav3 is a guanosine diphosphate/guanosine triphosphate exchange factor for Rho/Rac GTPases that has been involved in functions related to the hematopoietic…”
Get full text

Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome by Campuzano, Victoria, Segura-Puimedon, Maria, Terrado, Verena, Sánchez-Rodríguez, Carolina, Coustets, Mathilde, Menacho-Márquez, Mauricio, Nevado, Julián, Bustelo, Xosé R, Francke, Uta, Pérez-Jurado, Luis A

“…A hallmark feature of Williams-Beuren Syndrome (WBS) is a generalized arteriopathy due to elastin deficiency, presenting as stenoses of medium and large…”
Get full text

Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion by BARTOLOME, Rubén A, MOLINA-ORTIZ, Isabel, SAMANIEGO, Rafael, SANCHEZ-MATEOS, Paloma, BUSTELO, Xose R, TEIXIDO, Joaquin

“…Melanoma cells express the chemokine receptor CXCR4, which confers invasive signals on binding to its ligand CXCL12. We show here that knocking down…”
Get full text

Vav proteins, adaptors and cell signaling by Bustelo, X R

“…The Vav family is a group of signal transduction molecules with oncogenic potential that play important roles in development and cell signaling. Members of…”
Get full text

Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion by Patel, Vyomesh, Rosenfeldt, Hans M., Lyons, Ruth, Servitja, Joan-Marc, Bustelo, Xosé R., Siroff, Mary, Gutkind, J.Silvio

“…The poor prognosis associated with head and neck squamous cell carcinoma (HNSCC) is primarily due to both local invasion and the regional and/or distant…”
Get full text

CD147 Inhibits the Nuclear Factor of Activated T-cells by Impairing Vav1 and Rac1 Downstream Signaling by Ruiz, Sergio, Castro-Castro, Antonio, Bustelo, Xosé R.

“…CD147 is a transmembrane protein that plays crucial roles in the development and function of the reproductive, visual, and nervous systems. CD147 also exerts…”
Get full text