Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis

Abstract Objective The aim of the study described here was to examine the relationship between memory function, proton magnetic resonance spectroscopy (1 H-MRS) abnormalities, and interictal epileptiform discharge (IED) lateralization in patients with temporal lobe epilepsy (TLE) related to unilater...

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Published in:	Epilepsy & behavior Vol. 16; no. 3; pp. 447 - 453
Main Authors:	Mantoan, Marcele Araújo Silva, Caboclo, Luís Otávio Sales Ferreira, de Figueiredo Ferreira Guilhoto, Laura Maria, Lin, Katia, da Silva Noffs, Maria Helena, de Souza Silva Tudesco, Ivanda, Belzunces, Erich, Carrete, Henrique, Bussoletti, Renato Tavares, Centeno, Ricardo Silva, Sakamoto, Américo Ceiki, Yacubian, Elza Márcia Targas
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2009
Subjects:	Adult Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Choline - metabolism Creatine - metabolism Epilepsy, Temporal Lobe - complications Epilepsy, Temporal Lobe - metabolism Female Functional Laterality Humans Interictal epileptiform discharges Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Male Memory Memory Disorders - etiology Mesial temporal sclerosis Middle Aged Neurology Neuropsychological Tests Neuropsychology Proton magnetic resonance spectroscopy Protons Retrospective Studies Sclerosis - etiology Sclerosis - pathology Statistics as Topic Statistics, Nonparametric Temporal Lobe - metabolism Temporal Lobe - pathology Temporal lobe epilepsy Young Adult Interictal epileptiform discharges Proton magnetic resonance spectroscopy Temporal lobe epilepsy Mesial temporal sclerosis Neuropsychology Memory
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Summary:	Abstract Objective The aim of the study described here was to examine the relationship between memory function, proton magnetic resonance spectroscopy (1 H-MRS) abnormalities, and interictal epileptiform discharge (IED) lateralization in patients with temporal lobe epilepsy (TLE) related to unilateral mesial temporal sclerosis. Methods We assessed performance on tests of memory function and intelligence quotient (IQ) in 29 right-handed outpatients and 24 controls. IEDs were assessed on 30-minute-awake and 30-minute-sleep EEG samples. Patients had1 H-MRS at 1.5 T. Results There was a negative correlation between IQ ( P = 0.031) and Rey Auditory Verbal Learning Test results ( P = 0.022) and epilepsy duration; between1 H-MRS findings and epilepsy duration ( P = 0.027); and between N -acetylaspartate (NAA) levels and IEDs ( P = 0.006) in contralateral mesial temporal structures in the left MTS group.1 H-MRS findings, IEDs, and verbal function were correlated. Conclusions These findings suggest that IEDs and NAA/(Cho + Cr) ratios reflecting neural metabolism are closely related to verbal memory function in mesial temporal sclerosis. Higher interictal activity on the EEG was associated with a decline in total NAA in contralateral mesial temporal structures.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1525-5050 1525-5069
DOI:	10.1016/j.yebeh.2009.08.032