Search Results - "Bussolari, Jacqueline"

Randomized, Single-Blind, Multicenter Phase II Study of Two Doses of Imetelstat in Relapsed or Refractory Myelofibrosis by Mascarenhas, John, Komrokji, Rami S., Palandri, Francesca, Martino, Bruno, Niederwieser, Dietger, Reiter, Andreas, Scott, Bart L., Baer, Maria R., Hoffman, Ronald, Odenike, Olatoyosi, Vannucchi, Alessandro M., Bussolari, Jacqueline, Zhu, Eugene, Rose, Esther, Sherman, Laurie, Dougherty, Souria, Sun, Libo, Huang, Fei, Wan, Ying, Feller, Faye M., Rizo, Aleksandra, Kiladjian, Jean-Jacques

“…PURPOSE Patients with myelofibrosis who are relapsed or refractory (R/R) to Janus-associated kinase inhibitors (JAKis) have poor clinical outcomes including…”
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Myelosuppression in Patients Treated with the Telomerase Inhibitor Imetelstat Is Not Mediated through Activation of Toll-Like Receptors by Baerlocher, Gabriela M, Rusbuldt, Joshua, Bussolari, Jacqueline, Huang, Fei

“…Imetelstat sodium (GRN163L; hereafter, imetelstat) is a first-in-class telomerase inhibitor that has demonstrated activity in patients with myeloproliferative…”
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Favorable overall survival with imetelstat in relapsed/refractory myelofibrosis patients compared with real-world data by Kuykendall, Andrew T., Sun, Libo, Mascarenhas, John, Kiladjian, Jean-Jacques, Vannucchi, Alessandro M., Wang, Julia, Xia, Qi, Zhu, Eugene, Feller, Faye, Rizo, Aleksandra, Bussolari, Jacqueline, Wan, Ying, Komrokji, Rami

“…In the MYF2001 trial, treatment of Janus kinase (JAK) inhibitor-relapsed/refractory intermediate-2 or high-risk myelofibrosis (MF) with imetelstat 9.4 mg/kg…”
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P624: PHASE 1 STUDY OF JNJ‐67856633, A FIRST‐IN‐HUMAN HIGHLY SELECTIVE MALT1 INHIBITOR, IN RELAPSED/REFRACTORY (R/R) B‐CELL NON‐HODGKIN LYMPHOMA (B‐NHL) AND CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) by Kalac, Matko, Hertzberg, Mark, Cheah, Chan, Ribrag, Vincent, Abrisquet Acosta, Pablo, Opat, Stephen, Bachy, Emmanuel, Ysebaert, Loïc, Qiu, Lihua, Yi, Shuhua, Nishimura, Noriko, Lemech, Charlotte, Bussolari, Jacqueline, Deng, Changchun, Lu, Tianbao, Xiu, Liang, Van Hemelryck, Sandy, Philippar, Ulrike, Guo, Yue, Soete, Virginie, Soriano, Isabel, Fourneau, Nele, Gerecitano, John, Morschhauser, Franck

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A New Substrate for the Biginelli Cyclocondensation:  Direct Preparation of 5-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-ones from a β-Keto Carboxylic Acid by Bussolari, Jacqueline C, McDonnell, Patricia A

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Imetelstat Achieves Meaningful and Durable Transfusion Independence in High Transfusion-Burden Patients With Lower-Risk Myelodysplastic Syndromes in a Phase II Study by Steensma, David P, Fenaux, Pierre, Van Eygen, Koen, Raza, Azra, Santini, Valeria, Germing, Ulrich, Font, Patricia, Diez-Campelo, Maria, Thepot, Sylvain, Vellenga, Edo, Patnaik, Mrinal M, Jang, Jun Ho, Varsos, Helen, Bussolari, Jacqueline, Rose, Esther, Sherman, Laurie, Sun, Libo, Wan, Ying, Dougherty, Souria, Huang, Fei, Feller, Faye, Rizo, Aleksandra, Platzbecker, Uwe

“…Patients with lower-risk (LR) myelodysplastic syndromes (MDS) who are RBC transfusion dependent and have experienced relapse after or are refractory to…”
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Addition of Acrylamide to Amino Aldehydes to Generate Non-Baylis-Hillman Adducts. Formation of Novel N-Acylhemiaminals by Bussolari, Jacqueline C, Beers, Kimberly, Lalan, Praful, Murray, William V, Gauthier, Diane, McDonnell, Patricia

“…Aldol reactions of chiral aminoaldehydes and methylacrylate in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) produces β-hydroxy methylbutenoates which…”
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Abstract 2731: Impact of hypomethylating agents on hTERT expression and synergistic effect in combination with imetelstat, a telomerase inhibitor, in AML cell lines by Rusbuldt, Joshua, Bussolari, Jacqueline, Rizo, Aleksandra, Huang, Fei

“…Abstract The catalytic subunit of human telomerase (hTERT) is highly expressed in acute myeloid leukemia (AML). Transcriptional factors and epigenetic…”
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Abstract 1267: Combination therapy of JNJ-67856633, a novel, first-in-class MALT1 protease inhibitor, and JNJ-64264681, a novel BTK inhibitor, for the treatment of B-cell lymphomas by Philippar, Ulrike, Fontan, Lorena, Cornelissen, Ivo, Rui, Haopeng, Balasubramanian, Sriram, Gaudiano, Marcello, Bekkers, Mariette, Van Nuffel, Luc, Lu, Tianbao, Wiener, John, Tichenor, Mark, Greway, Tony, Packman, Kathryn, Verbist, Bie, Elsayed, Yusri, Attar, Ricardo, Bussolari, Jacqueline, Gerecitano, John

“…Abstract Background: Constitutive activation of the classical nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) pathway is a clear driver…”
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Characterization of Disease, Treatment Patterns, and Outcomes of Patients with Myelofibrosis: Analysis of 2 United States Commercial Claims Databases by Mehra, Maneesha, Potluri, Ravi, He, Jianming, Wang, Grace, Mundle, Suneel, Bussolari, Jacqueline

“…Introduction: Myelofibrosis (MF) is a myeloproliferative neoplasm with profound negative effects on quality of life and survival. MF is characterized by clonal…”
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Transfusion Burden and Outcomes in Patients with Low- or Unspecified-Grade Myelodysplastic Syndromes Treated with Erythropoiesis-Stimulating Agents: Analysis of a United States Commercial Claims Database by Mehra, Maneesha, Potluri, Ravi, He, Jianming, Rizo, Aleksandra, Mundle, Suneel, Bussolari, Jacqueline

“…Introduction: Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic disorders characterized by 1 or more peripheral blood…”
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Abstract 2732: Myelosuppression in patients treated with the telomerase inhibitor imetelstat is not mediated through activation of toll-like receptors by Baerlocher, Gabriela M., Rusbuldt, Joshua, Huang, Fei, Bussolari, Jacqueline

“…Abstract Imetelstat is a covalently lipidated 13-mer N3′-P5′ thio-phosphoramidate (NPS) oligonucleotide (5′-TAGGGTTAGACAA-3′) that is complementary to the RNA…”
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Abstract 1256: JNJ-74856665, a novel DHODH inhibitor, mediates potent anti-leukemic activity and differentiation in vitro and in vivo by Pietsch, Christine, Kuduk, Scott, Zhang, Xiaochun, Bush, Tammy, Kazmi, Faraz, Jacoby, Edgar, Zhang, Zhuming, DeRatt, Lindsey, Wang, Weixue, Patrick, Aaron, Steele, Andrew, Pastore, Friedericke, Greway, Tony, Daskalakis, Nikki, Bradford, Kathryn, Packman, Kathryn, Bignan, Gilles, Edwards, James, Attar, Ricardo, Elsayed, Yusri, Bussolari, Jacqueline, Philippar, Ulrike

“…Abstract Acute myeloid leukemia (AML) is a heterogeneous disease characterized by uncontrolled clonal expansion of hematopoietic progenitor cells (myeloid…”
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Imetelstat Is Effective Treatment for Patients with Intermediate-2 or High-Risk Myelofibrosis Who Have Relapsed on or Are Refractory to Janus Kinase Inhibitor Therapy: Results of a Phase 2 Randomized Study of Two Dose Levels by Mascarenhas, John, Komrokji, Rami S., Cavo, Michele, Martino, Bruno, Niederwieser, Dietger, Reiter, Andreas, Scott, Bart L, Baer, Maria R., Hoffman, Ronald, Odenike, Olatoyosi, Bussolari, Jacqueline, Zhu, Eugene, Huang, Fei, Rose, Esther, Sherman, Laurie, Dougherty, Souria, Feller, Faye M., Kiladjian, Jean-Jacques

“…Background: Imetelstat, a 13-mer oligonucleotide that specifically targets the RNA template of human telomerase, is a potent competitive inhibitor of…”
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Abstract 1101: Telomerase inhibitor imetelstat in combination with the BCL-2 inhibitor venetoclax enhances apoptosis in vitro and increases survival in vivo in acute myeloid leukemia by Rusbuldt, Joshua J., Luistro, Leopoldo, Chin, Diana, Smith, Melissa, Wong, Amy, Romero, Margarita, Rizo, Aleksandra, Bussolari, Jacqueline, Huang, Fei, Sasser, Amy (Kate)

“…Abstract Background/Aims: Acute myeloid leukemia (AML) is an aggressive cancer with limited treatment options outside of chemotherapy. Improved therapies with…”
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Imetelstat Treatment Leads to Durable Transfusion Independence (TI) in RBC Transfusion-Dependent (TD), Non-Del(5q) Lower Risk MDS Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) Who Are Lenalidomide (LEN) and HMA Naive by Steensma, David P., Platzbecker, Uwe, Van Eygen, Koen, Raza, Azra, Santini, Valeria, Germing, Ulrich, Font, Patricia, Samarina, Irina, Díez-Campelo, Maria, Thepot, Sylvain, Vellenga, Edo, Patnaik, Mrinal M., Jang, Jun Ho, Bussolari, Jacqueline, Sherman, Laurie, Sun, Libo, Varsos, Helen, Rose, Esther, Fenaux, Pierre

“…BACKGROUND: Patients with TD lower-risk (LR)-MDS relapsed or refractory to ESA have limited treatment options. Imetelstat is a first-in-class telomerase…”
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Phase 1 study of JNJ-42756493, a pan-fibroblast growth factor receptor (FGFR) inhibitor, in patients with advanced solid tumors by Bahleda, Rastislav, Dienstmann, Rodrigo, Adamo, Barbara, Gazzah, Anas, Infante, Jeffrey R., Zhong, Bob, Platero, Suso J., Smit, Hans, Perera, Timothy, Stuyckens, Kim, Bussolari, Jacqueline, Peddareddigari, Vijay, Soria, Jean-Charles, Luo, Feng Roger, Tabernero, Josep

“…Abstract only…”
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Decitabine Improves Outcomes in Older Patients with AML and Higher Blast Counts by Kadia, Tapan, Thomas, Xavier, Dmoszynska, Anna, Wierzbowska, Agnieszka, Minden, Mark, Arthur, Christopher, De Porre, Peter, Xiu, Liang, Doyle, Margaret, Bussolari, Jacqueline, Kantarjian, Hagop

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Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides by Bussolari, Jacqueline C, Ramesh, Kakarla, Stoeckler, Johanna D, Chen, Shih Fong, Panzica, Raymond P

“…The chemical synthesis of certain N4-substituted imidazo[4,5-d]pyridazine and v-triazolo[4,5-d]-pyridazine nucleosides is described. In both series, the…”
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Corrigendum to “Synthesis and anti-HIV evaluation of 2′,3′-dideoxy imidazo- and ν-triazolo[4,5-d]pyridazine nucleosides” by Bussolari, Jacqueline C, Panzica, Raymond P

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