Search Results - "Bussler, Holm"

SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease by Smith, Ernest S, Jonason, Alan, Reilly, Christine, Veeraraghavan, Janaki, Fisher, Terrence, Doherty, Michael, Klimatcheva, Ekaterina, Mallow, Crystal, Cornelius, Chad, Leonard, John E, Marchi, Nicola, Janigro, Damir, Argaw, Azeb Tadesse, Pham, Trinh, Seils, Jennifer, Bussler, Holm, Torno, Sebold, Kirk, Renee, Howell, Alan, Evans, Elizabeth E, Paris, Mark, Bowers, William J, John, Gareth, Zauderer, Maurice

“…Abstract Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell infiltration of CNS, blood–brain barrier (BBB) breakdown,…”
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CXCL13 antibody for the treatment of autoimmune disorders by Klimatcheva, Ekaterina, Pandina, Tracy, Reilly, Christine, Torno, Sebold, Bussler, Holm, Scrivens, Maria, Jonason, Alan, Mallow, Crystal, Doherty, Michael, Paris, Mark, Smith, Ernest S, Zauderer, Maurice

“…Homeostatic B Cell-Attracting chemokine 1 (BCA-1) otherwise known as CXCL13 is constitutively expressed in secondary lymphoid organs by follicular dendritic…”
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Use of poxvirus display to select antibodies specific for complex membrane antigens by Smith, Ernest S., Balch, Leslie A., Scrivens, Maria, Shi, Shuying, Wang, Wei, Harvey, Caroline D., Cornelison, Angelica A., Gil-Moore, Malgorzata, Kirk, Renee A., Mueller, Loretta L., Hall, Richard L., Howell, Alan P., Reilly, Christine A., Mayer, Jessica M., Murante, Francis G., Viggiani, Kari A, Gersz, Elaine M., Bussler, Holm, Keefe, Madeleine R., Evans, Elizabeth E., Paris, Mark J., Zauderer, Maurice

“…Antibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have…”
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Generation and preclinical characterization of an antibody specific for SEMA4D by Fisher, Terrence L, Reilly, Christine A, Winter, Laurie A, Pandina, Tracy, Jonason, Alan, Scrivens, Maria, Balch, Leslie, Bussler, Holm, Torno, Sebold, Seils, Jennifer, Mueller, Loretta, Huang, He, Klimatcheva, Ekaterina, Howell, Alan, Kirk, Renee, Evans, Elizabeth, Paris, Mark, Leonard, John E, Smith, Ernest S, Zauderer, Maurice

“…Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell…”
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Antibody blockade of semaphorin 4D breaks down barriers to enhance tumoricidal immune infiltration and supports rational immunotherapy combinations by Evans, Elizabeth E, Hu-Lieskovan, Siwen, Bussler, Holm, Torno, Sebold, Mallow, Crystal, Reilly, Christine, Scrivens, Maria, Klimatcheva, Ekaterina, Winter, Laurie A, Kirk, Renee, Howell, Alan, Balch, Leslie, Veeraraghavan, Janaki, Jonason, Alan S, Leonard, John E, Paris, Mark, Fisher, Terrence L, Ribas, Antoni, Smith, Ernest S, Zauderer, Maurice

“…Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 are broadly expressed in cancer and expression correlates with invasive disease in several human…”
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Mouse strain specificity of the IgE response to the major allergens of Phleum pratense by Seitzer, Ulrike, Bussler, Holm, Kullmann, Birgit, Petersen, Arnd, Becker, Wolf-Meinhard, Ahmed, Jabbar

“…IgE immune responses against major allergens from Phleum pratense in low- and high-responder mouse strains were compared and the influence of alum was…”
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Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies by Evans, Elizabeth E, Jonason, Jr, Alan S, Bussler, Holm, Torno, Sebold, Veeraraghavan, Janaki, Reilly, Christine, Doherty, Michael A, Seils, Jennifer, Winter, Laurie A, Mallow, Crystal, Kirk, Renee, Howell, Alan, Giralico, Susan, Scrivens, Maria, Klimatcheva, Katya, Fisher, Terrence L, Bowers, William J, Paris, Mark, Smith, Ernest S, Zauderer, Maurice

“…Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 (PLXNB1) are broadly expressed in murine and human tumors, and their expression has been shown to…”
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Abstract 1545: Altered myeloid and lymphoid composition of tumor microenvironment following anti-SEMA4D and immune checkpoint combination therapies by Evans, Elizabeth E., Fisher, Terrence L., Bussler, Holm, Mallow, Crystal, Reilly, Christine, Torno, Sebold, Pastore, Desa Rae, Scrivens, Maria, Howell, Alan, Balch, Leslie, Leonard, John E., Allen, Clint, Clavijo, Paul E., Lesinski, Gregory, Wu, Christina, Steuer, Conor, Saba, Nabil F., Olson, Brian, Hu-Lieskovan, Siwen, Ribas, Antoni, Greengard, Emily G., Smith, Ernest S., Zauderer, Maurice

“…Anti-semaphorin 4D (SEMA4D, CD100) blocking antibody promotes immune infiltration, reduces immunosuppressive myeloid cells, and enhances T cell activity and…”
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Abstract B199: Targeting the tumor microenvironment with first-in-class Semaphorin4D MAb for combination immunotherapy by Evans, Elizabeth E., Bussler, Holm, Mallow, Crystal, Reilly, Christine, Torno, Sebold, Scrivens, Maria, Foster, Cathie, Howell, Alan, Balch, Leslie, Leonard, John E., Fisher, Terrence L., Allen, Clint, Clavijo, Paul, Hu-Lieskovan, Siwen, Ribas, Antoni, Smith, Ernest S., Zauderer, Maurice

“…Purpose: Mechanistic findings in preclinical studies demonstrate that antibody blockade of Semaphorin 4D (SEMA4D, CD100) reduces expansion of MDSC and shifts…”
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Abstract 3661: Breaking down the barrier restricting infiltration and differentiation of APC in the tumor microenvironment with a first-in-class antibody targeting Semaphorin4D, and rational combination therapies by Evans, Elizabeth E., Bussler, Holm, Mallow, Crystal, Reilly, Christine, Torno, Sebold, Scrivens, Maria, Foster, Cathie, Howell, Alan, Comeau, Stephen R., Balch, Leslie, Knapp, Alyssa, Leonard, John E., Fisher, Terrence L., Hu-Lieskovan, Siwen, Ribas, Antoni, Smith, Ernest S., Zauderer, Maurice

“…Purpose: We expand mechanistic findings in preclinical studies to demonstrate that antibody blockade of Semaphorin 4D (SEMA4D, CD100) reduces expansion of MDSC…”
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Abstract 1762: Shifting the tumor microenvironment with first-in-class semaphorin 4D mab for combination immunotherapy by Evans, Elizabeth E., Bussler, Holm, Mallow, Crystal, Reilly, Christine, Torno, Sebold, Scrivens, Maria, Howell, Alan, Balch, Leslie, Leonard, John E., Fisher, Terrence, Allen, Clint, Clavijo, Paul E., Lesinski, Gregory, Wu, Christina, Hu-Lieskovan, Siwen, Ribas, Antoni, Greengard, Emily G., Smith, Ernest S., Zauderer, Maurice

“…Purpose: In preclinical models, tumor growth inhibition by anti-semaphorin 4D (SEMA4D, CD100) blocking antibody is enhanced when combined with various…”
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Abstract 4888: Antibody blockade of semaphorin 4D breaks down stromal barriers to enhance tumoricidal immune infiltration, supporting rational immunotherapy combinations by Evans, Elizabeth E., Bussler, Holm, Torno, Sebold, Mallow, Crystal, Reilly, Christine, Scrivens, Maria, Klimatcheva, Ekaterina, Winter, Laurie A., Kirk, Renee, Howell, Alan, Balch, Leslie, Leonard, John E., Paris, Mark, Fisher, Terrence L., Hu-Lieskovan, Siwen, Ribas, Antoni, Smith, Ernest S., Zauderer, Maurice

“…Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 are broadly expressed in cancer; increased expression correlates with poor prognosis. SEMA4D normally…”
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Antibody blockade of semaphorin 4D promotes infiltration of activated tumor infiltrating leukocytes and inhibits tumor growth. (TUM7P.1030) by Klimatcheva, Ekaterina, Evans, Elizabeth, Bussler, Holm, Torno, Sebold, Mallow, Crystal, Winter, Laurie, Reilly, Christine, Veeraraghavan, Janaki, Jonason, Alan S., Scrivens, Maria, Kirk, Renee, Giralico, Susan, Howell, Alan, Leonard, John, Paris, Mark, Fisher, Terrence, Smith, Ernest, Zauderer, Maurice

“…Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 are broadly expressed in cancer and expression correlates with invasive disease. A novel function of…”
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Development of anti-CXCL13 monoclonal antibody for the treatment of autoimmune and immuno-oncological disorders (THER2P.950) by Klimatcheva, Ekaterina, Mallow, Crystal, Reilly, Christine, Torno, Sebold, Bussler, Holm, Howell, Alan, Scrivens, Maria, Wang, Wei, Balch, Leslie, Murante, Frank, Foster, Cathrine, Kirk, Renee, Giralico, Susan, Leonard, John, Paris, Mark, Fisher, Terrence, Evans, Elizabeth, Smith, Ernest, Zauderer, Maurice

“…The chemokine CXCL13 is expressed in secondary lymphoid organs by follicular dendritic cells and macrophages and is also expressed by TH17 cells. It is the…”
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Abstract 278: Antibody blockade of semaphorin 4D promotes infiltration of activated tumor infiltrating leukocytes and reverses tumor growth by Evans, Elizabeth E., Bussler, Holm, Torno, Sebold, Mallow, Crystal, Winters, Laurie A., Reilly, Christine, Klimatcheva, Katya, Veeraraghavan, Janaki, Jonason, Alan S., Scrivens, Maria, Kirk, Renee, Giralico, Sue, Howell, Alan, Leonard, John E., Paris, Mark, Fisher, Terrence L., Smith, Ernest S., Zauderer, Maurice

“…Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 are broadly expressed in cancer and expression correlates with invasive disease in several human…”
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Abstract 5030: Antibody blockade of Semaphorin 4D promotes tumor rejection and improves response to immune checkpoint blockade and chemotherapy by Evans, Elizabeth E., Bussler, Holm, Torno, Sebold, Veeraraghavan, Janaki, Jonason, Alan S., Doherty, Michael A., Reilly, Christine, Mallow, Crystal, Seils, Jennifer, Paris, Mark, Fisher, Terrence L., Bowers, William J., Scrivens, Maria, Balch, Leslie, Kirk, Renee, Howell, Alan, Iddison, Valerie, Leonard, John E., Smith, Ernest S., Zauderer, Maurice

“…Semaphorin4D (SEMA4D) normally functions to regulate, adhesion, motility and activation state of multiple cell types including those of the nervous, vascular…”
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Abstract 1245: Reduction of tumor growth and metastasis by a humanized IgG4 monoclonal antibody to SEMA4D (VX15/2503) by Evans, Elizabeth E., Jonason, Alan S., Paris, Mark, Fisher, Terrence L., Torno, Sebold, Bussler, Holm, Decker, Jessica, Scrivens, Maria, Huang, He, Winter, Laurie A., Pandina, Tracy, Balch, Leslie, Doherty, Michael A., Kirk, Renee, Howell, Alan, Seils, Jennifer, Reilly, Christine, Zauderer, Maurice, Leonard, John E., Smith, Ernest S.

“…Semaphorin 4D (SEMA4D; CD100) has been implicated in several key mechanisms of tumor progression, including transactivation of several oncogenes, metastasis,…”
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Antibody-mediated neutralization of Sema4D reduces tumor angiogenesis and growth in vivo by Fisher, T., Jonason, Alan, Torno, Sebold, Bussler, Holm, Li, Ji, Evans, Elizabeth E., Watkins, Raymond, Zauderer, Maurice, Leonard, John E, Smith, Ernest S.

“…Abstract only…”
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Abstract 2531: Reduction of In Vivo Tumor Growth and Angiogenesis by a Humanized IgG4 Monoclonal Antibody to SEMA4D by Jonason, Alan S., Fisher, Terrence L., Torno, Sebold, Bussler, Holm, Doherty, Michael A., Winter, Laurie A., Reilly, Christine, Kirk, Renee, Howell, Alan, Huang, He, Caplan, Jeff, Kenney, Patrick, Scrivens, Maria, Pandina, Tracy, Croy, Leslie, Evans, Elizabeth E., Paris, Mark, Watkins, Raymond, Zauderer, Maurice, Leonard, John E., Smith, Ernest S.

“…Semaphorin 4D (SEMA4D; CD100) has been implicated in several key mechanisms of tumor progression, including metastasis, tumor invasion, and neovascularization…”
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Abstract 3667: Reduction of in vivo tumor growth and angiogenesis by a humanized IgG4 monoclonal antibody to SEMA4D by Jonason, Alan S., Fisher, Terrence L., Torno, Sebold, Bussler, Holm, Winter, Laurie A., Kirk, Renee, Howell, Alan, Caplan, Jeff, Kenney, Patrick, Reilly, Christine, Scrivens, Maria, Huang, He, Croy, Leslie, Evans, Elizabeth E., Paris, Mark, Watkins, Raymond, Zauderer, Maurice, Leonard, John E., Smith, Ernest S.

“…Semaphorin 4D (SEMA4D; CD100) has been implicated in several key mechanisms of tumor progression, including neovascularization, tumor invasion, and metastasis…”
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