Search Results - "Bussière, T."

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease by GIANNAKOPOULOS, P, HERRMANN, F. R, BUSSIERE, T, BOURAS, C, KÖVARI, E, PERL, D. P, MORRISON, J. H, GOLD, G, HOF, P. R

“…To examine the relationship between stereologic estimates of AD-related pathology and severity of cognitive deficits in brain aging. Previous studies reported…”
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Predicting Relapse: A Meta-Analysis of Sexual Offender Recidivism Studies by Hanson, R. Karl, Bussière, Monique T

“…Evidence from 61 follow-up studies was examined to identify the factors most strongly related to recidivism among sexual offenders. On average, the sexual…”
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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders by Buée, Luc, Bussière, Thierry, Buée-Scherrer, Valérie, Delacourte, André, Hof, Patrick R.

“…Tau proteins belong to the family of microtubule-associated proteins. They are mainly expressed in neurons where they play an important role in the assembly of…”
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Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer’s disease by Bussière, T., Friend, P.D., Sadeghi, N., Wicinski, B., Lin, G.I., Bouras, C., Giannakopoulos, P., Robakis, N.K., Morrison, J.H., Perl, D.P., Hof, P.R.

“…Although the presence of amyloid deposits is required to establish the neuropathologic diagnosis of Alzheimer’s disease, from a clinical point of view, a…”
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Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration by BUSSIERE, T, HOF, P. R, MAILLIOT, C, BROWN, C. D, CAILLET-BOUDIN, M. L, PERL, D. P, BUEE, L, DELACOURTE, A

“…Neuronal inclusions with bundles of abnormal filaments made of tau polymers are found in numerous diseases with neurofibrillary degeneration. Tau proteins are…”
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Phosphorylation of specific sets of tau isoforms reflects different neurofibrillary degeneration processes by Mailliot, Christel, Sergeant, Nicolas, Bussière, Thierry, Caillet-Boudin, Marie-Laure, Delacourte, André, Buée, Luc

“…Tau proteins are the basic components of filaments that accumulate within neurons during neurofibrillary degeneration, a degenerating process with…”
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Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies by Maurage, C.-A., Bussière, T., Sergeant, N., Ghesteem, A., Figarella-Branger, D., Ruchoux, M.-M., Pellissier, J.-F., Delacourte, A.

“…Sporadic inclusion body myositis (s‐IBM) is the most frequent progressive acquired inflammatory myopathy in people older than 50 years. Abnormal aggregates of…”
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impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells by Bussiere, C. T, Lakey, J. R. T, Shapiro, A. M. J, Korbutt, G. S

“…Aims/hypothesis The Edmonton Protocol for islet transplantation has provided hope for type 1 diabetic patients. However, this protocol requires lifelong…”
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Practical approaches to stereology in the setting of aging- and disease-related brain banks by Perl, Daniel P, Good, Paul F, Bussière, Thierry, Morrison, John H, Erwin, Joseph M, Hof, Patrick R

“…The unbiased sampling techniques of stereology have been developed to avoid the inaccuracies of using ‘representative’ sections for morphometric studies. In…”
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Isoelectric point differentiates PHF-tau from biopsy-derived human brain tau proteins by Sergeant, N, Bussière, T, Vermersch, P, Lejeune, J P, Delacourte, A

“…In the present study, Tau proteins were detected by two monoclonal antibodies AD2 and Tau-1 raised against PHF-tau and normal Tau proteins respectively using…”
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Pathological Tau Phenotypes: The Weight of Mutations, Polymorphisms, and Differential Neuronal Vulnerabilities by MAILLIOT, CHRISTEL, BUSSIÈRE, THIERRY, HAMDANE, MALIKA, SERGEANT, NICOLAS, CAILLET, MARIE-LAURE, DELACOURTE, ANDRÉ, BUÉE, LUC

“…: In tauopathies, comparative biochemistry of tau aggregates shows that they differ in both phosphorylation and content of tau isoforms. Six tau isoforms are…”
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Alzheimer-specific epitope of AT100 in transfected cell lines with tau: toward an efficient cell model of tau abnormal phosphorylation by Mailliot, Christel, Bussière, Thierry, Caillet-Boudin, Marie-Laure, Delacourte, André, Buée, Luc

“…Intraneuronal aggregation of specific hyperphosphorylated tau isoforms in subsets of neurons may explain many neurodegenerative processes. Only some antibodies…”
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Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer’s disease by Bussire, T, Gold, G, Kvari, E, Giannakopoulos, P, Bouras, C, Perl, D.P, Morrison, J.H, Hof, P.R

“…Alzheimer’s disease (AD) is characterized neuropathologically by several features including extensive neuronal death in the cerebral cortex. In fact, while…”
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Clinical validity of Aβ-protein deposition staging in brain aging and Alzheimer disease by GOLD, Gabriel, KÖVARI, Enikö, CORTE, Gina, HERRMANN, Francois R, CANUTO, Alessandra, BUSSIERE, Thierry, HOF, Patrick R, BOURAS, Constantin, GIANNAKOPOULOS, Panteleimon

“…Braak's neurofibrillary tangle (NFT) pathology staging system of Alzheimer disease (AD) correlates generally with clinical data. Recently, Braak's group…”
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The mechanical function and structure of aortic microfibrils in the lobster Homarus americanus by Bussiere, Chantal T., Wright, Glenda M., DeMont, M. Edwin

“…Marfan syndrome, a connective tissue disorder affecting the cardiovascular system, is caused by mutations of fibrillin-based microfibrils. These mutations…”
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A tepary bean diet and exercise delays indices of type 2 diabetes in female fa/fa rats by Rodgers, Carol D., Burch, Pam E., VanHeest, Jaci L., Suzuki, K., Bussiere, Chantal T., Schemmel, Rachel A.

“…Legumes have been shown to protect against the development of type 2 diabetes (T2D). Previous work has focused on the impact of legumes on the glycemic index…”
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Data suggest antibody's clinical benefit in treatment of Alzheimer's disease by Sevigny, J, Chiao, P, Bussiere, T

“…A year of monthly infusions of the human monoclonal antibody aducanumab reduced amyloid‐ß (Aß) plaques in patients with prodromal or mild Alzheimer's disease,…”
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Morphological Characterization of Thioflavin-S-Positive Amyloid Plaques in Transgenic Alzheimer Mice and Effect of Passive Aβ Immunotherapy on Their Clearance by Bussière, Thierry, Bard, Frédérique, Barbour, Robin, Grajeda, Henry, Guido, Terry, Khan, Karen, Schenk, Dale, Games, Dora, Seubert, Peter, Buttini, Manuel

“…Transgenic mice mimicking certain features of Alzheimer's disease (AD)-pathology, namely amyloid plaques and neurofibrillary tangles, have been developed in an…”
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Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: Stereologic analysis of prefrontal cortex area 9 by Bussière, Thierry, Giannakopoulos, Panteleimon, Bouras, Constantin, Perl, Daniel P., Morrison, John H., Hof, Patrick R.

“…We performed a stereologic analysis of a subset of pyramidal neurons known to be vulnerable in Alzheimer's disease (AD) and characterized by particularly high…”
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Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins—a role in nuclear localization by Lefebvre, Tony, Ferreira, Stéphanie, Dupont-Wallois, Laetitia, Bussière, Thierry, Dupire, Marie-Joëlle, Delacourte, André, Michalski, Jean-Claude, Caillet-Boudin, Marie-Laure

“…Both phosphorylation and O-GlcNAc glycosylation posttranslationally modify microtubule-associated Tau proteins. Whereas the hyperphosphorylation of these…”
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