Search Results - "Bussey, Kimberly J."

Ancient genes establish stress-induced mutation as a hallmark of cancer by Cisneros, Luis, Bussey, Kimberly J, Orr, Adam J, Miočević, Milica, Lineweaver, Charles H, Davies, Paul

“…Cancer is sometimes depicted as a reversion to single cell behavior in cells adapted to live in a multicellular assembly. If this is the case, one would expect…”
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Identification of a signature of evolutionarily conserved stress-induced mutagenesis in cancer by Cisneros, Luis H, Vaske, Charles, Bussey, Kimberly J

“…The clustering of mutations observed in cancer cells is reminiscent of the stress-induced mutagenesis (SIM) response in bacteria. Bacteria deploy SIM when…”
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Pathway Implications of Aberrant Global Methylation in Adrenocortical Cancer by Legendre, Christophe R, Demeure, Michael J, Whitsett, Timothy G, Gooden, Gerald C, Bussey, Kimberly J, Jung, Sungwon, Waibhav, Tembe, Kim, Seungchan, Salhia, Bodour

“…Adrenocortical carcinomas (ACC) are a rare tumor type with a poor five-year survival rate and limited treatment options. Understanding of the molecular…”
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Whole-genome Sequencing of an Aggressive BRAF Wild-type Papillary Thyroid Cancer Identified EML4–ALK Translocation as a Therapeutic Target by Demeure, Michael J., Aziz, Meraj, Rosenberg, Richard, Gurley, Steven D., Bussey, Kimberly J., Carpten, John D.

“…Background Recent advances in the treatment of cancer have focused on targeting genomic aberrations with selective therapeutic agents. In radioiodine resistant…”
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PTTG1 overexpression in adrenocortical cancer is associated with poor survival and represents a potential therapeutic target by Demeure, Michael J., MD, MBA, Coan, Kathryn E., MD, Grant, Clive S., MD, Komorowski, Richard A., MD, Stephan, Elizabeth, PhD, Sinari, Shripad, MS, Mount, David, PhD, Bussey, Kimberly J., PhD

“…Background Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC gene expression profiling data…”
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Isotropic 3D nuclear morphometry of normal, fibrocystic and malignant breast epithelial cells reveals new structural alterations by Nandakumar, Vivek, Kelbauskas, Laimonas, Hernandez, Kathryn F, Lintecum, Kelly M, Senechal, Patti, Bussey, Kimberly J, Davies, Paul C W, Johnson, Roger H, Meldrum, Deirdre R

“…Grading schemes for breast cancer diagnosis are predominantly based on pathologists' qualitative assessment of altered nuclear structure from 2D brightfield…”
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Proteomic Profiling of the NCI-60 Cancer Cell Lines Using New High-Density Reverse-Phase Lysate Microarrays by Nishizuka, Satoshi, Charboneau, Lu, Young, Lynn, Major, Sylvia, Reinhold, William C., Waltham, Mark, Kouros-Mehr, Hosein, Bussey, Kimberly J., Lee, Jae K., Espina, Virginia, Munson, Peter J., Petricoin, Emanuel, Liotta, Lance A., Weinstein, John N.

“…Because most potential molecular markers and targets are proteins, proteomic profiling is expected to yield more direct answers to functional and…”
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Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel by Bussey, Kimberly J, Chin, Koei, Lababidi, Samir, Reimers, Mark, Reinhold, William C, Kuo, Wen-Lin, Gwadry, Fuad, Ajay, Kouros-Mehr, Hosein, Fridlyand, Jane, Jain, Ajay, Collins, Colin, Nishizuka, Satoshi, Tonon, Giovanni, Roschke, Anna, Gehlhaus, Kristen, Kirsch, Ilan, Scudiero, Dominic A, Gray, Joe W, Weinstein, John N

“…Chromosome rearrangement, a hallmark of cancer, has profound effects on carcinogenesis and tumor phenotype. We used a panel of 60 human cancer cell lines (the…”
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Asparagine synthetase as a causal, predictive biomarker for l-asparaginase activity in ovarian cancer cells by Lorenzi, Philip L, Reinhold, William C, Rudelius, Martina, Gunsior, Michele, Shankavaram, Uma, Bussey, Kimberly J, Scherf, Uwe, Eichler, Gabriel S, Martin, Scott E, Chin, Koei, Gray, Joe W, Kohn, Elise C, Horak, Ivan D, Von Hoff, Daniel D, Raffeld, Mark, Goldsmith, Paul K, Caplen, Natasha J, Weinstein, John N

“…l -Asparaginase ( l -ASP), a bacterial enzyme used since the 1970s to treat acute lymphoblastic leukemia, selectively starves cells that cannot synthesize…”
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Adrenocortical Cancer by Wandoloski, Melissa, BS, Bussey, Kimberly J., PhD, Demeure, Michael J., MD, MBA

“…Adrenocortical carcinoma (ACC) is a rare endocrine malignancy causing up to 0.2% of all cancer deaths This article reviews the incidence, presentation, and…”
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Cancer progression as a sequence of atavistic reversions by Lineweaver, Charles H., Bussey, Kimberly J., Blackburn, Anneke C., Davies, Paul C. W.

“…It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi‐unicellular phenotype. This general concept…”
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GoMiner: a resource for biological interpretation of genomic and proteomic data by Zeeberg, Barry R, Feng, Weimin, Wang, Geoffrey, Wang, May D, Fojo, Anthony T, Sunshine, Margot, Narasimhan, Sudarshan, Kane, David W, Reinhold, William C, Lababidi, Samir, Bussey, Kimberly J, Riss, Joseph, Barrett, J Carl, Weinstein, John N

“…We have developed GoMiner, a program package that organizes lists of 'interesting' genes (for example, under- and overexpressed genes from a microarray…”
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New Validated Tool to Diagnose Breastfeeding Dysfunction by Agarwal, Rajeev, Eddis-Finbow, Mars, Tam, Jodie, Broatch, Jennifer, Bussey, Kimberly J.

“…Background: Breastfeeding behaviors and experiences exist on a continuum. What differentiates normal from dysfunctional is defined by frequency and severity…”
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Reverting to single-cell biology: The predictions of the atavism theory of cancer by Bussey, Kimberly J., Davies, Paul C.W.

“…Cancer or cancer-like phenomena pervade multicellular life, implying deep evolutionary roots. Many of the hallmarks of cancer recapitulate unicellular…”
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Mistaken identifiers: gene name errors can be introduced inadvertently when using Excel in bioinformatics by Zeeberg, Barry R, Riss, Joseph, Kane, David W, Bussey, Kimberly J, Uchio, Edward, Linehan, W Marston, Barrett, J Carl, Weinstein, John N

“…When processing microarray data sets, we recently noticed that some gene names were being changed inadvertently to non-gene names. A little detective work…”
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Ancestral gene regulatory networks drive cancer by Bussey, Kimberly J., Cisneros, Luis H., Lineweaver, Charles H., Davies, Paul C. W.

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Predicting drug sensitivity and resistance: Profiling ABC transporter genes in cancer cells by Szakács, Gergely, Annereau, Jean-Philippe, Lababidi, Samir, Shankavaram, Uma, Arciello, Angela, Bussey, Kimberly J., Reinhold, William, Guo, Yanping, Kruh, Gary D., Reimers, Mark, Weinstein, John N., Gottesman, Michael M.

“…For analysis of multidrug resistance, a major barrier to effective cancer chemotherapy, we profiled mRNA expression of the 48 known human ABC transporters in…”
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Membrane transporters and channels: Role of the transportome in Cancer chemosensitivity and chemoresistance by YING HUANG, ANDERLE, Pascale, BUSSEY, Kimberly J, BARBACIORU, Catalin, SHANKAVARAM, Uma, ZUNYAN DAI, REINHOLD, William C, PAPP, Audrey, WEINSTEIN, John N, SADEE, Wolfgang

“…Membrane transporters and channels (collectively the transportome) govern cellular influx and efflux of ions, nutrients, and drugs. We used oligonucleotide…”
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MatchMiner: a tool for batch navigation among gene and gene product identifiers by Bussey, Kimberly J, Kane, David, Sunshine, Margot, Narasimhan, Sudar, Nishizuka, Satoshi, Reinhold, William C, Zeeberg, Barry, Ajay, Weinstein, Weinstein, John N

“…MatchMiner is a freely available program package for batch navigation among gene and gene product identifier types commonly encountered in microarray studies…”
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Karyotypic complexity of the NCI-60 drug-screening panel by ROSCHKE, Anna V, TONON, Giovanni, GEHLHAUS, Kristen S, MCTYRE, Nicolas, BUSSEY, Kimberly J, LABABIDI, Samir, SCUDIERO, Dominic A, WEINSTEIN, John N, KIRSCH, Ilan R

“…We used spectral karyotyping to provide a detailed analysis of karyotypic aberrations in the diverse group of cancer cell lines established by the National…”
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