Search Results - "Bussey, J"

Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential by Reichelt, Amy C., Hare, Dominic J., Bussey, Timothy J., Saksida, Lisa M.

“…The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs…”
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Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation by Clelland, C.D, Choi, M, Romberg, C, Clemenson, G.D. Jr, Fragniere, A, Tyers, P, Jessberger, S, Saksida, L.M, Barker, R.A, Gage, F.H, Bussey, T.J

“…The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation--the formation of distinct and orthogonal representations of…”
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Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval by Winters, Boyer D., Saksida, Lisa M., Bussey, Timothy J.

“…Tests of object recognition memory, or the judgment of the prior occurrence of an object, have made substantial contributions to our understanding of the…”
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Running enhances spatial pattern separation in mice by Creer, David J, Romberg, Carola, Saksida, Lisa M, van Praag, Henriette, Bussey, Timothy J

“…Increasing evidence suggests that regular exercise improves brain health and promotes synaptic plasticity and hippocampal neurogenesis. Exercise improves…”
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TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD by White, Matthew A., Kim, Eosu, Duffy, Amanda, Adalbert, Robert, Phillips, Benjamin U., Peters, Owen M., Stephenson, Jodie, Yang, Sujeong, Massenzio, Francesca, Lin, Ziqiang, Andrews, Simon, Segonds-Pichon, Anne, Metterville, Jake, Saksida, Lisa M., Mead, Richard, Ribchester, Richard R, Barhomi, Youssef, Serre, Thomas, Coleman, Michael P., Fallon, Justin R., Bussey, Timothy J., Brown, Robert H., Sreedharan, Jemeen

“…Amyotrophic lateral sclerosis–frontotemporal dementia (ALS-FTD) constitutes a devastating disease spectrum characterized by 43-kDa TAR DNA-binding protein…”
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The m-chi decomposition of hybrid dual-polarimetric radar data with application to lunar craters by Raney, R. Keith, Cahill, Joshua T. S., Patterson, G. Wesley, Bussey, D. Benjamin J.

“…We introduce a new technique derived from the classical Stokes parameters for analysis of polarimetric radar astronomical data. This decomposition is based on…”
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The touchscreen operant platform for testing learning and memory in rats and mice by Horner, Alexa E, Heath, Christopher J, Hvoslef-Eide, Martha, Kent, Brianne A, Kim, Chi Hun, Nilsson, Simon R O, Alsiö, Johan, Oomen, Charlotte A, Holmes, Andrew, Saksida, Lisa M, Bussey, Timothy J

“…An increasingly popular method of assessing cognitive functions in rodents is the automated touchscreen platform, on which a number of different cognitive…”
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Can animals recall the past and plan for the future? by Clayton, Nicola S, Bussey, Timothy J, Dickinson, Anthony

“…According to the 'mental time travel hypothesis' animals, unlike humans, cannot mentally travel backwards in time to recollect specific past events (episodic…”
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Visual perception and memory : A new view of medial temporal lobe function in primates and rodents by MURRAY, Elisabeth A, BUSSEY, Timothy J, SAKSIDA, Lisa M

“…The prevailing view of medial temporal lobe (MTL) function has two principal elements: first, that the MTL subserves memory but not perception, and second,…”
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The touchscreen operant platform for assessing executive function in rats and mice by Mar, Adam C, Horner, Alexa E, Nilsson, Simon R O, Alsiö, Johan, Kent, Brianne A, Kim, Chi Hun, Holmes, Andrew, Saksida, Lisa M, Bussey, Timothy J

“…This protocol details a subset of assays developed within the touchscreen platform to measure various aspects of executive function in rodents. Three main…”
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Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable? by Bekinschtein, Pedro, Oomen, Charlotte A., Saksida, Lisa M., Bussey, Timothy J.

“…► Environmental enrichment is associated with increased learning and memory. ► Voluntary exercise is associated with increased learning and memory. ►…”
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The touchscreen operant platform for testing working memory and pattern separation in rats and mice by Oomen, Charlotte A, Hvoslef-Eide, Martha, Heath, Christopher J, Mar, Adam C, Horner, Alexa E, Bussey, Timothy J, Saksida, Lisa M

“…The automated touchscreen operant chamber for rats and mice allows for the assessment of multiple cognitive domains within the same testing environment. This…”
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Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models by Lyon, L., Saksida, L. M., Bussey, T. J.

“…Rationale Spontaneous (novel) object recognition (SOR) is one of the most widely used rodent behavioural tests. The opportunity for rapid data collection has…”
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Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs by Heath, Christopher J., Bussey, Timothy J., Saksida, Lisa M.

“…Rationale Touchscreens are widely used to examine rodent cognition. Current paradigms require animals to view stimuli and nose poke at an appropriate…”
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Two-dimensional distribution of volatiles in the lunar regolith from space weathering simulations by Hurley, Dana M., Lawrence, David J., Bussey, D. Benjamin J., Vondrak, Richard R., Elphic, Richard C., Gladstone, G. Randall

“…We present simulations of space weathering effects on ice deposits in regions of permanent shadow on the Moon. These Monte Carlo simulations follow the effects…”
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Basal Forebrain and Brainstem Cholinergic Neurons Differentially Impact Amygdala Circuits and Learning-Related Behavior by Aitta-aho, Teemu, Hay, Y. Audrey, Phillips, Benjamin U., Saksida, Lisa M., Bussey, Tim J., Paulsen, Ole, Apergis-Schoute, John

“…The central cholinergic system and the amygdala are important for motivation and mnemonic processes. Different cholinergic populations innervate the amygdala,…”
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Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex by Romberg, Carola, Yang, Sujeong, Melani, Riccardo, Andrews, Melissa R, Horner, Alexa E, Spillantini, Maria G, Bussey, Timothy J, Fawcett, James W, Pizzorusso, Tommaso, Saksida, Lisa M

“…Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal cell bodies and proximal dendrites and are involved in the control…”
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Intact Memory for Irrelevant Information Impairs Perception in Amnesia by Barense, Morgan D., Groen, Iris I.A., Lee, Andy C.H., Yeung, Lok-Kin, Brady, Sinead M., Gregori, Mariella, Kapur, Narinder, Bussey, Timothy J., Saksida, Lisa M., Henson, Richard N.A.

“…Memory and perception have long been considered separate cognitive processes, and amnesia resulting from medial temporal lobe (MTL) damage is thought to…”
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Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption by Reichelt, Amy C., Lemieux, Claire A., Princz-Lebel, Oren, Singh, Ashmita, Bussey, Timothy J., Saksida, Lisa M.

“…Emergent evidence demonstrates that excessive consumption of high fat and high sugar (HFHS) diets has negative consequences on hippocampal and prefrontal…”
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Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept) by Romberg, Carola, Mattson, Mark P, Mughal, Mohamed R, Bussey, Timothy J, Saksida, Lisa M

“…Several mouse models of Alzheimer's disease (AD) with abundant β-amyloid and/or aberrantly phosphorylated tau develop memory impairments. However, multiple…”
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