Search Results - "Bussey, Carol"

Photoactivation of tDodSNO induces localized vasodilation in rats: Metabolically stable S-nitrosothiols can act as targeted nitric oxide donors in vivo by Giles, Gregory I., Erickson, Jeffrey R., Bussey, Carol T.

“…Nitric oxide (NO) is a key vasodilatory signalling molecule and NO releasing molecules (NO donors) are being examined as potential treatments for many…”
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Uncovering Anti‐Arrhythmic Potential of Stellate Ganglion Purinergic Receptors by Bussey, Carol T., Davis, Harvey, Bogert, Emma, Paterson, David J., Paton, Julian F.

“…Cardiovascular disease affects over 30% of people worldwide and is one of the leading causes of death each year. Elevated sympathetic nerve activity is a…”
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Depressed HCN4 function in the type 2 diabetic sinoatrial node by Parveen, Sajida, Cheah, Paddy H. S., Worthington, Luke P. I., Smither, Roseanna A., Munro, Michelle L., Bussey, Carol T., Lamberts, Regis R., Jones, Peter P.

“…Diabetic patients often have impaired heart rate (HR) control. HR is regulated both intrinsically within the sinoatrial node (SAN) and via neuronal input…”
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Increased Efferent Cardiac Sympathetic Nerve Activity and Defective Intrinsic Heart Rate Regulation in Type 2 Diabetes by Thaung, H P Aye, Baldi, J Chris, Wang, Heng-Yu, Hughes, Gillian, Cook, Rosalind F, Bussey, Carol T, Sheard, Phil W, Bahn, Andrew, Jones, Peter P, Schwenke, Daryl O, Lamberts, Regis R

“…Elevated sympathetic nerve activity (SNA) coupled with dysregulated β-adrenoceptor (β-AR) signaling is postulated as a major driving force for cardiac…”
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Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease by Boyett, Mark R., Yanni, Joseph, Tellez, James, Bucchi, Annalisa, Mesirca, Pietro, Cai, Xue, Logantha, Sunil Jit R.J., Wilson, Claire, Anderson, Cali, Ariyaratnam, Jonathan, Stuart, Luke, Nakao, Shu, Abd Allah, Eman, Jones, Sandra, Lancaster, Matthew, Stephenson, Robert, Chandler, Natalie, Smith, Matthew, Bussey, Carol, Monfredi, Oliver, Morris, Gwilym, Billeter, Rudi, Mangoni, Matteo E., Zhang, Henggui, Hart, George, D'Souza, Alicia

“…The funny current, If, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that If plays an…”
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Increased neuronal activation in sympathoregulatory regions of the brain and spinal cord in type 2 diabetic rats by Sethi, Shivani, Augustine, Rachael A., Bouwer, Gregory T., Perkinson, Michael R., Cheong, Isaiah, Bussey, Carol T., Schwenke, Daryl O., Brown, Colin H., Lamberts, Regis R.

“…Increased cardiac sympathetic nerve activity in type 2 diabetes mellitus (DM) suggests impaired autonomic control of the heart. However, the central regions…”
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Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro by Daniels, Lorna J., Annandale, Marco, Koutsifeli, Parisa, Li, Xun, Bussey, Carol T., van Hout, Isabelle, Bunton, Richard W., Davis, Philip J., Coffey, Sean, Katare, Rajesh, Lamberts, Regis R., Delbridge, Lea M. D., Mellor, Kimberley M.

“…Diabetes is associated with cardiac metabolic disturbances and increased heart failure risk. Plasma fructose levels are elevated in diabetic patients. A direct…”
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Cardiac β‐adrenergic responsiveness of obese Zucker rats: The role of AMPK by Bussey, Carol T., Thaung, H. P. Aye, Hughes, Gillian, Bahn, Andrew, Lamberts, Regis R.

“…New Findings What is the central question of the study? Is the reduced signalling of AMP‐activated protein kinase (AMPK), a key regulator of energy homeostasis…”
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β 2 -Adrenoceptors indirectly support impaired β 1 -adrenoceptor responsiveness in the isolated type 2 diabetic rat heart by Cook, Rosalind F, Bussey, Carol T, Fomison-Nurse, Ingrid C, Hughes, Gillian, Bahn, Andrew, Cragg, Patricia A, Lamberts, Regis R

“…What is the central question of this study? Are there specific contributions of β - and β -adrenoceptor subtypes to the impaired β-adrenoceptor responsiveness…”
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β2‐Adrenoceptors indirectly support impaired β1‐adrenoceptor responsiveness in the isolated type 2 diabetic rat heart by Cook, Rosalind F., Bussey, Carol T., Fomison‐Nurse, Ingrid C., Hughes, Gillian, Bahn, Andrew, Cragg, Patricia A., Lamberts, Regis R.

“…New Findings What is the central question of this study? Are there specific contributions of β1‐ and β2‐adrenoceptor subtypes to the impaired β‐adrenoceptor…”
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β1‐Adrenoceptor, but not β2‐adrenoceptor, subtype regulates heart rate in type 2 diabetic rats in vivo by Cook, Rosalind F., Bussey, Carol T., Mellor, Kimberley M., Cragg, Patricia A., Lamberts, Regis R.

“…New Findings What is the central question of the study? The sympathetic system regulates heart rate via β‐adrenoceptors; this is impaired during diabetes…”
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Adiponectin opposes endothelin-1-mediated vasoconstriction in the perfused rat hindlimb by Bussey, Carol T, Kolka, Cathryn M, Rattigan, Stephen, Richards, Stephen M

“…Recent studies have shown that adiponectin is able to increase nitric oxide (NO) production by the endothelium and relax preconstricted isolated aortic rings,…”
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Carvedilol and metoprolol are both able to preserve myocardial function in type 2 diabetes by Bussey, Carol T., Babakr, Aram A., Iremonger, Rachael R., Hout, Isabelle, Wilkins, Gerard T., Lamberts, Regis R., Erickson, Jeffrey R.

“…Purpose Increasing cohorts of patients present with diabetic cardiomyopathy, and with no targeted options, treatment often rely on generic pharmaceuticals such…”
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Increased haemodynamic adrenergic load with isoflurane anaesthesia in type 2 diabetic and obese rats in vivo by Bussey, Carol T, de Leeuw, Anne E, Lamberts, Regis R

“…Increasing numbers of type 2 diabetic and obese patients with enhanced rates of cardiovascular complications require surgical interventions, however they have…”
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Effect of type 2 diabetes, surgical incision, and volatile anesthesia on hemodynamics in the rat by Bussey, Carol T., Lamberts, Regis R.

“…Diabetic patients have increased cardiac complications during surgery, possibly due to impaired autonomic regulation. Anesthesia lowers blood pressure and…”
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β 1 -Adrenoceptor, but not β 2 -adrenoceptor, subtype regulates heart rate in type 2 diabetic rats in vivo by Cook, Rosalind F, Bussey, Carol T, Mellor, Kimberley M, Cragg, Patricia A, Lamberts, Regis R

“…What is the central question of the study? The sympathetic system regulates heart rate via β-adrenoceptors; this is impaired during diabetes. However, the…”
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Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β‐adrenergic responsiveness in hypertensive type 1 diabetic rats by Thaung, H. P. Aye, Yao, Yimin, Bussey, Carol T., Hughes, Gillian, Jones, Peter P., Bahn, Andrew, Sammut, Ivan A., Lamberts, Regis R.

“…New Findings What is the central question of this study? Can bilateral renal denervation, an effective antihypertensive treatment in clinical and experimental…”
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Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction by Bussey, Carol T, Hughes, Gillian, Saxena, Pankaj, Galvin, Ivor F, Bunton, Richard W, Noye, Marilyn K, Coffey, Sean, Williams, Michael J.A, Baldi, J. Chris, Jones, Peter P, Lamberts, Regis R

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Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not [beta]-adrenergic responsiveness in hypertensive type 1 diabetic rats by Thaung, H P Aye, Yao, Yimin, Bussey, Carol T, Hughes, Gillian, Jones, Peter P, Bahn, Andrew, Sammut, Ivan A, Lamberts, Regis R

“…New Findings What is the central question of this study? Can bilateral renal denervation, an effective antihypertensive treatment in clinical and experimental…”
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Untangling purinergic regulation through the stellate ganglion by Bussey, Carol, Davis, Harvey, Bogart, Emma, Paterson, David, Paton, Julian

“…Abstract only Sympathetic nerve overactivity is a key contributor to cardiovascular diseases, and related morbidity and mortality. Denervation of the stellate…”
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