Search Results - "Busse, Tracy"

SWI/SNF chromatin remodeling complexes and cancer by Biegel, Jaclyn A., Busse, Tracy M., Weissman, Bernard E.

“…The identification of mutations and deletions in the SMARCB1 locus in chromosome band 22q11.2 in pediatric rhabdoid tumors provided the first evidence for the…”
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OncoKids: A Comprehensive Next-Generation Sequencing Panel for Pediatric Malignancies by Hiemenz, Matthew C, Ostrow, Dejerianne G, Busse, Tracy M, Buckley, Jonathan, Maglinte, Dennis T, Bootwalla, Moiz, Done, James, Ji, Jianling, Raca, Gordana, Ryutov, Alex, Xu, Xinjie, Zhen, Chao Jie, Conroy, Jeffrey M, Hazard, Florette K, Deignan, Joshua L, Rogers, Beverly B, Treece, Amanda L, Parham, David M, Gai, Xiaowu, Judkins, Alexander R, Triche, Timothy J, Biegel, Jaclyn A

“…The OncoKids panel is an amplification-based next-generation sequencing assay designed to detect diagnostic, prognostic, and therapeutic markers across the…”
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Copy number alterations determined by single nucleotide polymorphism array testing in the clinical laboratory are indicative of gene fusions in pediatric cancer patients by Busse, Tracy M., Roth, Jacquelyn J., Wilmoth, Donna, Wainwright, Luanne, Tooke, Laura, Biegel, Jaclyn A.

“…Gene fusions resulting from structural rearrangements are an established mechanism of tumorigenesis in pediatric cancer. In this clinical cohort, 1,350 single…”
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Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target by Weingart, Melanie F, Roth, Jacquelyn J, Hutt-Cabezas, Marianne, Busse, Tracy M, Kaur, Harpreet, Price, Antoinette, Maynard, Rachael, Rubens, Jeffrey, Taylor, Isabella, Mao, Xing-Gang, Xu, Jingying, Kuwahara, Yasumichi, Allen, Sariah J, Erdreich-Epstein, Anat, Weissman, Bernard E, Orr, Brent A, Eberhart, Charles G, Biegel, Jaclyn A, Raabe, Eric H

“…Atypical teratoid rhabdoid tumor (AT/RT) is among the most fatal of all pediatric brain tumors. Aside from loss of function mutations in the SMARCB1…”
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Clonal evolution and clinical significance of copy number neutral loss of heterozygosity of chromosome arm 6p in acquired aplastic anemia by Betensky, Marisol, Babushok, Daria, Roth, Jacquelyn J, Mason, Philip J, Biegel, Jaclyn A, Busse, Tracy M, Li, Yimei, Lind, Curt, Papazoglou, Anna, Monos, Dimitri, Podsakoff, Gregory, Bessler, Monica, Olson, Timothy S

“…Acquired aplastic anemia (aAA) results from the T cell-mediated autoimmune destruction of hematopoietic stem cells. Factors predicting response to immune…”
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FE65 Constitutes the Functional Link between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein by Pietrzik, Claus U, Yoon, Il-Sang, Jaeger, Sebastian, Busse, Tracy, Weggen, Sascha, Koo, Edward H

“…Increasing evidence has implicated the low density lipoprotein receptor-related protein (LRP) and the adaptor protein FE65 in Alzheimer's disease pathogenesis…”
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Diagnostic application of high resolution single nucleotide polymorphism array analysis for children with brain tumors by Roth, Jacquelyn J, Santi, Mariarita, Rorke-Adams, Lucy B, Harding, Brian N, Busse, Tracy M, Tooke, Laura S, Biegel, Jaclyn A

“…Single nucleotide polymorphism (SNP) array analysis is currently used as a first tier test for pediatric brain tumors at The Children's Hospital of…”
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Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway by Yoon, Il-Sang, Chen, Eunice, Busse, Tracy, Repetto, Emanuela, Lakshmana, Madepalli K, Koo, Edward H, Kang, David E

“…The major defining pathological hallmark of Alzheimer's disease (AD) is the accumulation of amyloid β protein (Aβ), a small peptide derived from β- and…”
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Presenilins Mediate Phosphatidylinositol 3-Kinase/AKT and ERK Activation via Select Signaling Receptors by Kang, David E., Yoon, Il Sang, Repetto, Emanuela, Busse, Tracy, Yermian, Nader, Ie, Listya, Koo, Edward H.

“…The Alzheimer's disease-linked genes, PS1 and PS2, are required for intramembrane proteolysis of multiple type I proteins, including Notch and amyloid…”
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Abstract 1384: A comprehensive gene panel for precise diagnosis and treatment of childhood cancer by Triche, Timothy J., Biegel, Jackie, Judkins, Alex, Busse, Tracy, Wayne, Alan, Bhojwani, Deepa, Asgharzadeh, Shahab, Oberley, Matthew, Parham, David

“…We have created and are validating a targeted gene panel that utilizes 20ng of FFPE DNA and 10 ng of FFPE RNA in a simple, 3-tube Ion AmpliSeq assay suitable…”
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Abstract B45: Development of a next-generation sequencing (NGS) assay for pediatric, childhood, and young adult cancer research with comprehensive DNA and RNA variant detection by Khazanov, Nickolay A., Parikh, Chaitali, Hamidi, Habib, Myrand, Scott P., Ballesteros-Villagrana, Efren, Ni, Jingwei, Williams, Paul D., Clyde, Karen L., Cyanam, Dinesh, Bankhead, Armand, Manivannan, Manimozhi, Tomilo, Mark, Ewald, Susan, Sherlock, Jon K., Au-Young, Janice K., Biegel, Jaclyn, Buckley, Jonathan, Hiemenz, Matthew, Ostrow, Dejerianne, Judkins, Alex, Gai, Xiaowu, Busse, Tracy, Wayne, Alan, Bhojwani, Deepa, Gordana, Raca, Oberley, Matthew, Parham, David, Sadis, Seth, Triche, Timothy

“…Introduction: Recurrent somatic alterations associated with pediatric, childhood, and young adult cancers have not been as intensively studied as those…”
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OncoKids by Hiemenz, Matthew C., Ostrow, Dejerianne G., Busse, Tracy M., Buckley, Jonathan, Maglinte, Dennis T., Bootwalla, Moiz, Done, James, Ji, Jianling, Raca, Gordana, Ryutov, Alex, Xu, Xinjie, Zhen, Chao Jie, Conroy, Jeffrey M., Hazard, Florette K., Deignan, Joshua L., Rogers, Beverly B., Treece, Amanda L., Parham, David M., Gai, Xiaowu, Judkins, Alexander R., Triche, Timothy J., Biegel, Jaclyn A.

“…The OncoKids panel is an amplification-based next-generation sequencing assay designed to detect diagnostic, prognostic, and therapeutic markers across the…”
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The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing by Pietrzik, Claus U., Busse, Tracy, Merriam, David E., Weggen, Sascha, Koo, Edward H.

“…The low‐density lipoprotein receptor‐related protein (LRP) has recently been implicated in numerous intracellular signaling functions, as well as in…”
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Applying the Grossman et al. Theoretical Framework: The Case of Reading by Kucan, Linda, Palincsar, Annemarie Sullivan, Busse, Tracy, Heisey, Natalie, Klingelhofer, Rachel, Rimbey, Michelle, Schutz, Kristine

“…Background/Context This article describes the application of the theoretical framework proposed by Grossman and her colleagues to a research effort focusing on…”
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Abstract 2977: Most patients with acquired aplastic anemia develop clonal hematopoiesis early in disease by Babushok, Daria V., Perdigones, Nieves, Perin, Juan C., Olson, Timothy S., Ye, Wenda, Roth, Jacquelyn J., Lind, Curt, Cattier, Carine, Li, Yimei, Hartung, Helge, Paessler, Michele E., Frank, Dale M., Xie, Hongbo M., Busse, Tracy M., Cross, Shanna, Podsakoff, Gregory M., Monos, Dimitrios, Biegel, Jaclyn A., Mason, Philip J., Bessler, Monica

“…Clonal hematopoiesis is an expansion of hematopoietic stem cells, caused by somatic mutations or epigenetic changes that confer a growth advantage to the host…”
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Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling by Kang, David E, Yoon, Il Sang, Repetto, Emanuela, Busse, Tracy, Yermian, Nader, Ie, Listya, Koo, Edward H

“…The Alzheimer's disease-linked genes, PS1 and PS2, are required for intramembrane proteolysis of multiple type I proteins, including Notch and amyloid…”
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Detection of Gene Fusions in Pediatric Hematologic Malignancies and Solid Tumors With the OncoKids Next Generation Sequencing Based Assay by Biegel, Jaclyn, Triche, Timothy, Ostrow, D. Gigi, Buckley, Jonathan, Busse, Tracy, Gai, Xiaowu, Judkins, Alexander, Maglinte, Dennis, Raca, Gordana, Hiemenz, Matthew

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29 - Detection of Gene Fusions in Pediatric Hematologic Malignancies and Solid Tumors With the OncoKids Next Generation Sequencing Based Assay by Biegel, Jaclyn, Triche, Timothy, Ostrow, D. Gigi, Buckley, Jonathan, Busse, Tracy, Gai, Xiaowu, Judkins, Alexander, Maglinte, Dennis, Raca, Gordana, Hiemenz, Matthew

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High-Resolution genomic arrays identify CNVs that phenocopy the chromosome 22q11.2 deletion syndrome by Busse, Tracy, Graham Jr, John M., Feldman, Gerald, Perin, Juan, Catherwood, Anne, Knowlton, Robert, Rappaport, Eric F., Emanuel, Beverly, Driscoll, Deborah A., Saitta, Sulagna C.

“…The 22q11 Deletion Syndrome includes the overlapping phenotypes of DiGeorge/Velocardiofacial Syndromes, characterized by conotruncal heart defects, cleft…”
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Applying the Grossman et al. Theoretical Framework: The Case of Reading by Kucan, Linda, Palincsar, Annemarie Sullivan, Busse, Tracy, Heisey, Natalie, Klingelhofer, Rachel, Rimbey, Michelle, Schutz, Kristine

“…This article describes the application of the theoretical framework proposed by Grossman and her colleagues to a research effort focusing on text-based…”
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