Search Results - "Buske, Fabian A."

Triplexator: detecting nucleic acid triple helices in genomic and transcriptomic data by Buske, Fabian A, Bauer, Denis C, Mattick, John S, Bailey, Timothy L

“…Double-stranded DNA is able to form triple-helical structures by accommodating a third nucleotide strand in its major groove. This sequence-specific process…”
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Potential in vivo roles of nucleic acid triple-helices by Buske, Fabian A., Mattick, John S., Bailey, Timothy L.

“…The ability of double-stranded DNA to form a triple-helical structure by hydrogen bonding with a third strand is well established, but the biological functions…”
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Assigning roles to DNA regulatory motifs using comparative genomics by Buske, Fabian A., Bodén, Mikael, Bauer, Denis C., Bailey, Timothy L.

“…Motivation: Transcription factors (TFs) are crucial during the lifetime of the cell. Their functional roles are defined by the genes they regulate. Uncovering…”
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WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors by Motamedi, Fariba Jian, Badro, Danielle A., Clarkson, Michael, Rita Lecca, M, Bradford, Stephen T., Buske, Fabian A., Saar, Kathrin, Hübner, Norbert, Brändli, André W., Schedl, Andreas

“…Kidney organogenesis requires the tight control of proliferation, differentiation and apoptosis of renal progenitor cells. How the balance between these…”
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Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer by Valdés-Mora, Fátima, Gould, Cathryn M., Colino-Sanguino, Yolanda, Qu, Wenjia, Song, Jenny Z., Taylor, Kylie M., Buske, Fabian A., Statham, Aaron L., Nair, Shalima S., Armstrong, Nicola J., Kench, James G., Lee, Kenneth M. L., Horvath, Lisa G., Qiu, Minru, Ilinykh, Alexei, Yeo-Teh, Nicole S., Gallego-Ortega, David, Stirzaker, Clare, Clark, Susan J.

“…Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active promoters and is associated with oncogene activation in prostate cancer, but its role in…”
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Dual-functioning transcription factors in the developmental gene network of Drosophila melanogaster by Bauer, Denis C, Buske, Fabian A, Bailey, Timothy L

“…Quantitative models for transcriptional regulation have shown great promise for advancing our understanding of the biological mechanisms underlying gene…”
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Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations by Taberlay, Phillippa C, Achinger-Kawecka, Joanna, Lun, Aaron T L, Buske, Fabian A, Sabir, Kenneth, Gould, Cathryn M, Zotenko, Elena, Bert, Saul A, Giles, Katherine A, Bauer, Denis C, Smyth, Gordon K, Stirzaker, Clare, O'Donoghue, Sean I, Clark, Susan J

“…A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial…”
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MEME SUITE: tools for motif discovery and searching by Bailey, Timothy L, Boden, Mikael, Buske, Fabian A, Frith, Martin, Grant, Charles E, Clementi, Luca, Ren, Jingyuan, Li, Wilfred W, Noble, William S

“…The MEME Suite web server provides a unified portal for online discovery and analysis of sequence motifs representing features such as DNA binding sites and…”
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Epigenetic priors for identifying active transcription factor binding sites by Cuellar-Partida, Gabriel, Buske, Fabian A., McLeay, Robert C., Whitington, Tom, Noble, William Stafford, Bailey, Timothy L.

“…Motivation Accurate knowledge of the genome-wide binding of transcription factors in a particular cell type or under a particular condition is necessary for…”
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Aquaria: simplifying discovery and insight from protein structures by O'Donoghue, Seán I, Sabir, Kenneth S, Kalemanov, Maria, Stolte, Christian, Wellmann, Benjamin, Ho, Vivian, Roos, Manfred, Perdigão, Nelson, Buske, Fabian A, Heinrich, Julian, Rost, Burkhard, Schafferhans, Andrea

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Triplex-Inspector: an analysis tool for triplex-mediated targeting of genomic loci by Buske, Fabian A, Bauer, Denis C, Mattick, John S, Bailey, Timothy L

“…At the heart of many modern biotechnological and therapeutic applications lies the need to target specific genomic loci with pinpoint accuracy. Although…”
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VariantSpark: population scale clustering of genotype information by O'Brien, Aidan R, Saunders, Neil F W, Guo, Yi, Buske, Fabian A, Scott, Rodney J, Bauer, Denis C

“…Genomic information is increasingly used in medical practice giving rise to the need for efficient analysis methodology able to cope with thousands of…”
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Genomics and personalised whole-of-life healthcare by Bauer, Denis C, Gaff, Clara, Dinger, Marcel E, Caramins, Melody, Buske, Fabian A, Fenech, Michael, Hansen, David, Cobiac, Lynne

“…Highlights • Technical advances utilising genomics promise personalised, evidence-based healthcare. • Overstatements for common diseases risk/outcome…”
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NGSANE: a lightweight production informatics framework for high-throughput data analysis by Buske, Fabian A., French, Hugh J., Smith, Martin A., Clark, Susan J., Bauer, Denis C.

“…The initial steps in the analysis of next-generation sequencing data can be automated by way of software ‘pipelines’. However, individual components depreciate…”
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Sorting the nuclear proteome by Bauer, Denis C., Willadsen, Kai, Buske, Fabian A., Lê Cao, Kim-Anh, Bailey, Timothy L., Dellaire, Graham, Bodén, Mikael

“…Motivation: Quantitative experimental analyses of the nuclear interior reveal a morphologically structured yet dynamic mix of membraneless compartments. Major…”
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In silico characterization of protein chimeras: Relating sequence and function within the same fold by Buske, Fabian A., Their, Ricarda, Gillam, Elizabeth M. J., Bodén, Mikael

“…The exploration of novel proteins via recombination of fragments derived from structurally homologous proteins has enormous potential for medicine and…”
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Predicting SUMOylation sites in developmental transcription factors of Drosophila melanogaster by Bauer, Denis C., Buske, Fabian A., Bailey, Timothy L., Bodén, Mikael

“…Recent evidence suggests that SUMOylation of proteins plays a keys role in the assembly and dis-assembly of nuclear sub-compartments, as well as gene…”
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It's about time : Signal recognition in staged models of protein translocation: Pattern Recognition in Computational Life Sciences by BUSKE, Fabian A, MAETSCHKE, Stefan, BODEN, Mikael

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It's about time: Signal recognition in staged models of protein translocation by Buske, Fabian A., Maetschke, Stefan, Bodén, Mikael

“…During their synthesis, a large fraction of proteins are directed to the secretory pathway. There are several models that aim to distinguish between different…”
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Detecting sequence and structure homology via an integrative kernel: A case-study in recognizing enzymes by Arieshanti, I., Boden, M., Maetschke, S., Buske, F.A.

“…Sequence and structure are complementary pieces of information that can be used to infer protein function. We study and compare sequence, structure and…”
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