Histological study of a corrective influence of a compound potassium 2-((4-amino-5-(morpholinomethyl)- 4h-1,2,4-triazol-3-yl)thio)acetate (PKR-173) on the state of chicken's liver under infection by Pseudomonas aeruginosa

Objective: The aim of the research is the histological study of the corrective effect of the compound potassium 2((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3yl)thio)acetate (PKR-173) with different antibiotics on the state of chicken's liver under infection by Pseudomonas aeruginosa. Mater...

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Published in:	Ankara Üniversitesi Eczacılık Fakültesi dergisi = Journal of Faculty of Pharmacy of Ankara University Vol. 44; no. 1; pp. 1 - 17
Main Authors:	Vashchyk,Yevgenia, Shcherbyna,Roman, Parchenko,Volodymyr, Bushueva,Inna, Gutyj,Bogdan, Fotina,Hanna, Fotina,Tatiana, Stronskyi,Yuriy
Format:	Journal Article
Language:	English
Published:	Ankara Üniversitesi Eczacılık Fakültesi 2020
Subjects:	Sağlık Hizmetleri Tıp Ankara Türkiye saroflox pseudomonas enfeksiyonu hepatoprotektif etki hepatoprotective effect infection of pseudomonas hepatit hepatitis
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Summary:	Objective: The aim of the research is the histological study of the corrective effect of the compound potassium 2((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3yl)thio)acetate (PKR-173) with different antibiotics on the state of chicken's liver under infection by Pseudomonas aeruginosa. Material and Method: The histological study was carried out on the levers of intact chickens (intact control); chickens that were infected by the strain of Pseudomonas aeruginosa (controlled pathology); chickens that had (before being infected by Pseudomonas aeruginosa) preventive input of the compound PKR-173 with the classic antibiotic Enrofloxacin or with Saroflox (undergoing research); or were input Thiotriazolin with the classic antibiotic Enrofloxacin. Result and Discussion: As a result, it is stated, that preventive input of the compound PKR-173 with reseachable antibiotic Saroflox, as well as with classic antibiotic Enrofloxacin and Thiotriazolin with antibiotic Enrofloxacin, to chickens infected with pseudomonas aeruginosa, prevents from chickens' livers developing stereotypical morphological changes characteristic of nonspecific reactive hepatitis. Analysis of quantitative characteristics of pathological process that developed in chicken's liver infected with pseudomonas aeruginosa, and the corrective influence of researched methods showed that the compound PKR-173 with antibiotic Saroflox believably lowers displays of all signs of pathology compared to the controlled pathology.
ISSN:	1015-3918
DOI:	10.33483/jfpau.567757