Search Results - "Bush, Robin M"

Microsecond Molecular Dynamics Simulations of Influenza Neuraminidase Suggest a Mechanism for the Increased Virulence of Stalk-Deletion Mutants by Durrant, Jacob D, Bush, Robin M, Amaro, Rommie E

“…Deletions in the stalk of the influenza neuraminidase (NA) surface protein are associated with increased virulence, but the mechanisms responsible for this…”
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Mechanism of 150-cavity formation in influenza neuraminidase by Amaro, Rommie E., Swift, Robert V., Votapka, Lane, Li, Wilfred W., Walker, Ross C., Bush, Robin M.

“…The recently discovered 150-cavity in the active site of group-1 influenza A neuraminidase (NA) proteins provides a target for rational structure-based drug…”
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A 3-dimensional trimeric β-barrel model for Chlamydia MOMP contains conserved and novel elements of Gram-negative bacterial porins by Feher, Victoria A, Randall, Arlo, Baldi, Pierre, Bush, Robin M, de la Maza, Luis M, Amaro, Rommie E

“…Chlamydia trachomatis is the most prevalent cause of bacterial sexually transmitted diseases and the leading cause of preventable blindness worldwide. Global…”
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Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for the identification of organisms by Everett, K D, Bush, R M, Andersen, A A

“…The current taxonomic classification of Chlamydia is based on limited phenotypic, morphologic and genetic criteria. This classification does not take into…”
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A Computational Assay that Explores the Hemagglutinin/Neuraminidase Functional Balance Reveals the Neuraminidase Secondary Site as a Novel Anti-Influenza Target by Amaro, Rommie E, Ieong, Pek U, Huber, Gary, Dommer, Abigail, Steven, Alasdair C, Bush, Robin M, Durrant, Jacob D, Votapka, Lane W

“…Studies of pathogen–host specificity, virulence, and transmissibility are critical for basic research as well as for assessing the pandemic potential of…”
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Quantifying Interhospital Patient Sharing as a Mechanism for Infectious Disease Spread by Huang, Susan S., Avery, Taliser R., Song, Yeohan, Elkins, Kristen R., Nguyen, Christopher C., Nutter, Sandra K., Nafday, Alaka A., Condon, Curtis J., Chang, Michael T., Chrest, David, Boos, John, Bobashev, Georgiy, Wheaton, William, Frank, Steven A., Platt, Richard, Lipsitch, Marc, Bush, Robin M., Eubank, Stephen, Burke, Donald S., Lee, Bruce Y.

“…Assessments of infectious disease spread in hospitals seldom account for interfacility patient sharing. This is particularly important for pathogens with…”
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Predicting the Evolution of Human Influenza A by Bush, Robin M., Bender, Catherine A., Subbarao, Kanta, Cox, Nancy J., Fitch, Walter M.

“…Eighteen codons in the HA1 domain of the hemagglutinin genes of human influenza A subtype H3 appear to be under positive selection to change the amino acid…”
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Long Term Trends in the Evolution of H(3) HA1 Human Influenza Type A by Fitch, Walter M., Bush, Robin M., Bender, Catherine A., Cox, Nancy J.

“…We have studied the HA1 domain of 254 human influenza A(H3N2) virus genes for clues that might help identify characteristics of hemagglutinins (HAs) of…”
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Influenza as a model system for studying the cross–species transfer and evolution of the SARS coronavirus by Bush, Robin M., Bush, Robin M.

“…Severe acute respiratory syndrome coronavirus (SARS–CoV) moved into humans from a reservoir species and subsequently caused an epidemic in its new host. We…”
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Barriers to antigenic escape by pathogens: trade-off between reproductive rate and antigenic mutability by Frank, Steven A, Bush, Robin M

“…A single measles vaccination provides lifelong protection. No antigenic variants that escape immunity have been observed. By contrast, influenza continually…”
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Ecological and immunological determinants of influenza evolution by Ferguson, Neil M, Galvani, Alison P, Bush, Robin M

“…In pandemic and epidemic forms, influenza causes substantial, sometimes catastrophic, morbidity and mortality. Intense selection from the host immune system…”
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Effects of Passage History and Sampling Bias on Phylogenetic Reconstruction of Human Influenza A Evolution by Bush, Robin M., Smith, Catherine B., Cox, Nancy J., Fitch, Walter M.

“…In this paper we determine the extent to which host-mediated mutations and a known sampling bias affect evolutionary studies of human influenza A. Previous…”
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Predicting adaptive evolution by Bush, Robin M

“…Phylogenetic trees reconstruct past evolution and can provide evidence of past evolutionary pressure on genes and on individual codons. In addition to tracing…”
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Prediction of the membrane‐spanning β‐strands of the major outer membrane protein of Chlamydia by Rodríguez‐Marañón, María José, Bush, Robin M., Peterson, Ellena M., Schirmer, Tilman, de la Maza, Luis M.

“…There is preliminary experimental evidence indicating that the major outer‐membrane protein (MOMP) of Chlamydia is a porin. We tested this hypothesis for the…”
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unspliced group I intron in 23S rRNA links Chlamydiales, chloroplasts, and mitochondria by Everett, K.D.E, Kahane, S, Bush, R.M, Friedman, M.G

“…Chlamydia was the only genus in the order Chlamydiales until the recent characterization of Simkania negevensis Z(T) and Parachlamydia acanthamoebae strains…”
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Influenza evolution and immune selection by Ferguson, Neil M, Bush, Robin M

“…Given its antigenic variability, transmissibility and high mutation rate, the limited genetic diversity of influenza A subtypes and the relative constancy of…”
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An Unspliced Group I Intron in 23S rRNA LinksChlamydiales, Chloroplasts, and Mitochondria by Everett, Karin D. E., Kahane, Simona, Bush, Robin M., Friedman, Maureen G.

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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EVOLUTION OF β‐GLUCURONIDASE REGULATION IN THE GENUS MUS by Bush, Robin M., Paigen, Kenneth

“…Despite the central role suggested for regulatory mutations in many evolutionary scenarios, there is relatively little information available about the type and…”
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The Impact of Electrophoretic Genotype on Life History Traits in Pinus taeda by Bush, Robin M., Smouse, Peter E.

“…Reports of positive associations between allozymic heterozygosity and measures of fitness are routine, but it has not been possible to distinguish between the…”
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Evolution of β-Glucuronidase Regulation in the Genus Mus by Bush, Robin M., Paigen, Kenneth

“…Despite the central role suggested for regulatory mutations in many evolutionary scenarios, there is relatively little information available about the type and…”
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