Search Results - "Busfield, Samantha J."

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice by Lee, Erwin M, Yee, Dean, Busfield, Samantha J, McManus, Julie F, Cummings, Nik, Vairo, Gino, Wei, Andrew, Ramshaw, Hayley S, Powell, Jason A, Lopez, Angel F, Lewis, Ian D, McCall, Martin N, Lock, Richard B

“…The prognosis of older patients with acute myelogenous leukemia is generally poor. The interleukin-3 receptor α-chain (CD123) is highly expressed on the…”
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Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody by Broughton, Sophie E., Hercus, Timothy R., Hardy, Matthew P., McClure, Barbara J., Nero, Tracy L., Dottore, Mara, Huynh, Huy, Braley, Hal, Barry, Emma F., Kan, Winnie L., Dhagat, Urmi, Scotney, Pierre, Hartman, Dallas, Busfield, Samantha J., Owczarek, Catherine M., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

“…Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the…”
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The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro by Vukovic, Jana, Ruitenberg, Marc J., Roet, Kasper, Franssen, Elske, Arulpragasam, Ajanthy, Sasaki, Takako, Verhaagen, Joost, Harvey, Alan R., Busfield, Samantha J., Plant, Giles W.

“…The primary olfactory pathway in adult mammals has retained a remarkable potential for self‐repair. A specialized glial cell within the olfactory nerve, called…”
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Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells by Jin, Liqing, Lee, Erwin M., Ramshaw, Hayley S., Busfield, Samantha J., Peoppl, Armando G., Wilkinson, Lucy, Guthridge, Mark A., Thomas, Daniel, Barry, Emma F., Boyd, Andrew, Gearing, David P., Vairo, Gino, Lopez, Angel F., Dick, John E., Lock, Richard B.

“…Leukemia stem cells (LSCs) initiate and sustain the acute myeloid leukemia (AML) clonal hierarchy and possess biological properties rendering them resistant to…”
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Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival by Ye, Qunrui, Fraser, Christopher C, Gao, Wei, Wang, Liqing, Busfield, Samantha J, Wang, Chichung, Qiu, Yubin, Coyle, Anthony J, Gutierrez-Ramos, Jose-Carlos, Hancock, Wayne W

“…LIGHT (TNFSF14), a tumor necrosis factor superfamily member expressed by activated T cells, binds to herpes virus entry mediator (HVEM) which is constitutively…”
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Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells by Nievergall, Eva, Ramshaw, Hayley S., Yong, Agnes S.M., Biondo, Mark, Busfield, Samantha J., Vairo, Gino, Lopez, Angel F., Hughes, Timothy P., White, Deborah L., Hiwase, Devendra K.

“…Despite the remarkable efficacy of tyrosine kinase inhibitors (TKIs) in eliminating differentiated chronic myeloid leukemia (CML) cells, recent evidence…”
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Generation and Characterization of Neuregulin-2-Deficient Mice by Britto, Joanne M., Lukehurst, Sherralee, Weller, Renae, Fraser, Chris, Qiu, Yubin, Hertzog, Paul, Busfield, Samantha J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cloning, Expression, and Function of BLAME, a Novel Member of the CD2 Family by Kingsbury, Gillian A, Feeney, Lee Ann, Nong, Yuhua, Calandra, Susan A, Murphy, Curran J, Corcoran, Justin M, Wang, Yanjun, Prabhu Das, Mercy R, Busfield, Samantha J, Fraser, Christopher C, Villeval, Jean Luc

“…The CD2 family is a growing family of Ig domain-containing cell surface proteins involved in lymphocyte activation. Here we describe the cloning and expression…”
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Identification of potent antagonist antibodies against mouse IL-13Rα1 using novel bioassays by Edwards, Kirsten M., Huynh, Huy, Prasad, Ranjeeta, McDonald, Anne, Hardy, Matthew P., Scotney, Pierre, Owczarek, Catherine M., Busfield, Samantha J., Panousis, Con, Wilson, Nicholas J.

“…Interleukin-13 (IL-13) is a cytokine implicated in airway diseases such as asthma and idiopathic pulmonary fibrosis. IL-13 signals through a heterodimeric…”
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Identification of potent antagonist antibodies against mouse IL-13R alpha 1 using novel bioassays by Edwards, Kirsten M, Huynh, Huy, Prasad, Ranjeeta, McDonald, Anne, Hardy, Matthew P, Scotney, Pierre, Owczarek, Catherine M, Busfield, Samantha J, Panousis, Con, Wilson, Nicholas J

“…Interleukin-13 (IL-13) is a cytokine implicated in airway diseases such as asthma and idiopathic pulmonary fibrosis. IL-13 signals through a heterodimeric…”
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Olfactory ensheathing cells: characteristics, genetic engineering, and therapeutic potential by Ruitenberg, Marc J, Vukovic, Jana, Sarich, Julijana, Busfield, Samantha J, Plant, Giles W

“…Injured neurons in the mammalian central nervous system (CNS) do not normally regenerate their axons after injury. Neurotrauma to the CNS usually results in…”
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A new nomenclature for IL-1-family genes by Sims, John E, Pan, Yang, Smith, Dirk E, Nicklin, Martin J.H, Barton, Jenny L, Bazan, J.Fernando, Kastelein, Robert A, Busfield, Samantha J, Ford, John E, Lin, Haishan, Mulero, Julio J, Kumar, Sanjay, Pan, James (Guohua), Young, Peter R

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Differential regulation of SOCS genes in normal and transformed erythroid cells by SARNA, Mohinder K, INGLEY, Evan, ALEXANDER, Warren S, HILTON, Douglas J, STARRY, Robyn, WATOWICH, Stephanie S, BITTORF, Thomas, KLINKEN, S. Peter, TILBROOK, Peta A, BUSFIELD, Samantha J, CULL, Vanessa S, LEPERE, Winald, MCCARTHY, David J, WRIGHT, Michael J, PALMER, Gene A, CHAPPELL, David, SAYER, Melissa S

“…The SOCS family of genes are negative regulators of cytokine signalling with SOCS-1 displaying tumor suppressor activity. SOCS-1, CIS and SOCS-3 have been…”
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Disrupted Signaling in a Mutant J2E Cell Line That Shows Enhanced Viability, but Does Not Proliferate or Differentiate, with Erythropoietin (∗) by Tilbrook, Peta A., Bittorf, Thomas, Busfield, Samantha J., Chappell, David, Klinken, S. Peter

“…The immature erythroid J2E cell line proliferates and terminally differentiates following erythropoietin stimulation. In contrast, the mutant J2E-NR clone does…”
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Karyotypic abnormalities associated with haemopoietic lineage switching are not linked with mutations to p53 by Colley, Shane M, Chappell, David S, Busfield, Samantha J, Voon, Dominic C, Klinken, S.Peter

“…Leukemic cells can undergo lineage switching to display the phenotypic features of another haemopoietic pathway, as exemplified by B lymphoma and…”
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A Neutralizing Antibody (CSL362) Against the Interleukin-3 Receptor α-Chain Augments the Efficacy of a Cytarabine/Daunorubicin Induction-Type Therapy in Preclinical Xenograft Models of Acute Myelogenous Leukemia by Lee, Erwin M, Yee, Dean, Busfield, Samantha J, Vairo, Gino, Lock, Richard B.

“…Abstract 3599 Despite the development of many new agents for the treatment of acute myelogenous leukemia (AML), the prognosis for most patients remains dismal…”
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High Plasma Levels of TGF-α and IL-6 at Diagnosis Predict Early Molecular Response Failure and Transformation in CML by Nievergall, Eva, Reynolds, John, Kok, Chung H, Watkins, Dale, Biondo, Mark, Busfield, Samantha J, Vairo, Gino, Yeung, David T, Lopez, Angel, Hiwase, Devendra K, White, Deborah L, Hughes, Timothy P

“…Introduction: Early molecular response (EMR, BCR-ABL (IS) ≤ 10% at 3 months) is a strong predictor of outcome in imatinib-treated chronic phase chronic myeloid…”
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Effective Elimination of CML Progenitor and Stem Cells Through Combination of α-CD123 Antibody-Dependent Cell-Mediated Cytotoxicity and Tyrosine Kinase Inhibitor Treatment by Nievergall, Eva, White, Deborah L., Yong, Agnes S.M., Ramshaw, Hayley S., Busfield, Samantha J., Vairo, Gino, Lopez, Angel F., Hughes, Timothy P., Hiwase, Devendra K.

“…Abstract 32 Since the introduction of tyrosine kinase inhibitor (TKI) therapy overall survival and complete molecular response rates in chronic phase chronic…”
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First-in Man, Phase 1 Study of CSL362 (Anti-IL3Rα / Anti-CD123 Monoclonal Antibody) in Patients with CD123+ Acute Myeloid Leukemia (AML) in CR at High Risk for Early Relapse by Smith, B. Douglas, Roboz, Gail J., Walter, Roland B., Altman, Jessica K., Ferguson, Anna, Curcio, Tania J., Orlowski, Kaysey F., Garrett, Linda, Busfield, Samantha J, Barnden, Megan, Sedgmen, Brad, Ghosh, Souravi, Hosback, Sarah, Davis, Roslyn, Dyson, Allison, Dasen, Sue, DeWitte, Mark, Bensen-Kennedy, Debra M., Roberts, Andrew W.

“…Background: Most patients with acute myeloid leukemia (AML) die from relapsed disease, including those who attain complete remission (CR). Post-remission…”
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78: Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123 by Hercus, Tim R., Broughton, Sophie E., Hardy, Matthew P., Nero, Tracy L., McClure, Barbara J., Dottore, Mara, Dhagat, Urmi, Barry, Emma F., Kan, Winnie L., Busfield, Samantha J., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

“…The ßc family of cytokines (GM-CSF, IL-3 and IL-5) are largely products of activated T cells and regulate the survival, proliferation, differentiation and…”
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