Search Results - "Buse, Maria G."

Hexosamines, insulin resistance, and the complications of diabetes: current status by Buse, Maria G

“…The hexosamine biosynthesis pathway (HBP) is a relatively minor branch of glycolysis. Fructose 6-phosphate is converted to glucosamine 6-phosphate, catalyzed…”
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O-Linked N-Acetylglucosamine Modification of Insulin Receptor Substrate-1 Occurs in Close Proximity to Multiple SH2 Domain Binding Motifs by Klein, Amanda L., Berkaw, Mary N., Buse, Maria G., Ball, Lauren E.

“…Insulin receptor substrate-1 (IRS-1) is a highly phosphorylated adaptor protein critical to insulin and IGF-1 receptor signaling. Ser/Thr kinases impact the…”
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Mechanisms of high-glucose/insulin-mediated desensitization of acute insulin-stimulated glucose transport and Akt activation by Robinson, Katherine A, Buse, Maria G

“…High-glucose/low-dose insulin-mediated insulin resistance of glucose transport was studied in 3T3-L1 adipocytes. In this model, proximal insulin signaling,…”
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Go-6976 reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes by Robinson, Katherine A, Hegyi, Krisztina, Hannun, Yusuf A, Buse, Maria G, Sethi, Jaswinder K

“…Chronic hyperglycemia induces insulin resistance by mechanisms that are incompletely understood. One model of hyperglycemia-induced insulin resistance involves…”
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Glucose, dexamethasone, and the unfolded protein response regulate TRB3 mRNA expression in 3T3-L1 adipocytes and L6 myotubes by Yacoub Wasef, Sherif Z, Robinson, Katherine A, Berkaw, Mary N, Buse, Maria G

“…Tribbles 3 (TRB3) is a recently recognized atypical inactive kinase that negatively regulates Akt activity in hepatocytes, resulting in insulin resistance…”
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Posttranslational regulation of thioredoxin-interacting protein by Robinson, Katherine A, Brock, Jonathan W, Buse, Maria G

“…Thioredoxin-interacting protein (Txnip) is a metabolic regulator, which modulates insulin sensitivity and likely plays a role in type 2 diabetes. We studied…”
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Reduction of O-GlcNAc protein modification does not prevent insulin resistance in 3T3-L1 adipocytes by Robinson, Katherine A, Ball, Lauren E, Buse, Maria G

“…3T3-L1 adipocytes develop insulin-resistant glucose transport upon preincubation with high (25 mM) glucose, provided that insulin (0.6 nM) is included, Akt…”
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Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1 by Ball, Lauren E, Berkaw, Mary N, Buse, Maria G

“…Signal transduction from the insulin receptor to downstream effectors is attenuated by phosphorylation at a number of Ser/Thr residues of insulin receptor…”
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High glucose and insulin promote O-GlcNAc modification of proteins, including alpha-tubulin by Walgren, Jennie L E, Vincent, Timothy S, Schey, Kevin L, Buse, Maria G

“…Increased flux through the hexosamine biosynthesis pathway has been implicated in the development of glucose-induced insulin resistance and may promote the…”
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Excessive Hexosamines Block the Neuroprotective Effect of Insulin and Induce Apoptosis in Retinal Neurons by Nakamura, Makoto, Barber, Alistair J., Antonetti, David A., LaNoue, Kathryn F., Robinson, Katherine A., Buse, Maria G., Gardner, Thomas W.

“…In addition to microvascular abnormalities, neuronal apoptosis occurs early in diabetic retinopathy, but the mechanism is unknown. Insulin may act as a…”
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Lower calorie intake enhances muscle insulin action and reduces hexosamine levels by Gazdag, A C, Wetter, T J, Davidson, R T, Robinson, K A, Buse, M G, Yee, A J, Turcotte, L P, Cartee, G D

“…Previous studies have demonstrated enhanced insulin sensitivity in calorie-restricted [CR, fed 60% ad libitum (AL) one time daily] compared with AL-fed rats…”
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Enhanced O-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles by Buse, Maria G, Robinson, Katherine A, Marshall, Bess A, Hresko, Richard C, Mueckler, Mike M

“…O-linked glycosylation on Ser/Thr with single N-acetylglucosamine (O-GlcNAcylation) is a reversible modification of many cytosolic/nuclear proteins, regulated…”
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High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes by NELSON, B. A, ROBINSON, K. A, BUSE, M. G

“…High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes. B A Nelson , K A Robinson and M G Buse Department of…”
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At therapeutic concentrations, olanzapine does not affect basal or insulin-stimulated glucose transport in 3T3-L1 adipocytes by Robinson, Katherine A., Yacoub Wasef, Sherif Z., Buse, Maria G.

“…The newer, atypical antipsychotic drugs have improved the treatment of schizophrenia and are widely used. A disadvantage is that they increase food intake,…”
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Defective Akt activation is associated with glucose- but not glucosamine-induced insulin resistance by Nelson, Bryce A, Robinson, Katherine A, Buse, Maria G

“…3T3-L1 adipocytes develop insulin-resistant glucose transport upon preincubation with high glucose or glucosamine, provided insulin (0.6 nM) is present during…”
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Effect of R(+)α-Lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes by Walgren, Jennie L, Amani, Zainab, McMillan, JoEllyn M, Locher, Mathias, Buse, Maria G

“…R-(+)-α-lipoic acid (R-LA) is the naturally occuring enantiomer of LA. It is a strong antioxidant and cofactor of key metabolic enzyme complexes catalyzing the…”
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Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle by KUROWSKI, T. G, YENSHOU LIN, ZHIJUN LUO, TSICHLIS, P. N, BUSE, M. G, HEYDRICK, S. J, RUDERMAN, N. B

“…Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. T G Kurowski , Y Lin , Z Luo ,…”
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Effects of diabetes and hyperglycemia on the hexosamine synthesis pathway in rat muscle and liver by ROBINSON, K. A, WEINSTEIN, M. L, LINDENMAYER, G. E, BUSE, M. G

“…In vitro studies suggested that increased flux of glucose through the hexosamine biosynthesis pathway (HexNSP) contributes to glucose-induced insulin…”
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A novel variant of glutamine: Fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle by DEHAVEN, John E, ROBINSON, Katherine A, NELSON, Bryce A, BUSE, Maria G

“…Glutamine:fructose-6-phosphate amidotransferase(GFAT) is the rate-limiting enzyme of the hexosamine synthesis pathway. Products of this pathway have been…”
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Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles : study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor by ROBINSON, K. A, SENS, D. A, BUSE, M. G

“…Increased routing of glucose through the hexosamine-biosynthetic pathway has been implicated in the development of glucose-induced insulin resistance of…”
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