Search Results - "Buschman, Matthew D."

GOLPH3 links the Golgi, DNA damage, and cancer by Buschman, Matthew D, Rahajeng, Juliati, Field, Seth J

“…GOLPH3 is the first example of an oncogene that functions in secretory trafficking at the Golgi. The discovery of GOLPH3's roles in both cancer and Golgi…”
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Efficient Golgi Forward Trafficking Requires GOLPH3-Driven, PI4P-Dependent Membrane Curvature by Rahajeng, Juliati, Kuna, Ramya S., Makowski, Stefanie L., Tran, Thuy T.T., Buschman, Matthew D., Li, Sheng, Cheng, Norton, Ng, Michelle M., Field, Seth J.

“…Vesicle budding for Golgi-to-plasma membrane trafficking is a key step in secretion. Proteins that induce curvature of the Golgi membrane are predicted to be…”
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DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3 by Farber-Katz, Suzette E., Dippold, Holly C., Buschman, Matthew D., Peterman, Marshall C., Xing, Mengke, Noakes, Christopher J., Tat, John, Ng, Michelle M., Rahajeng, Juliati, Cowan, David M., Fuchs, Greg J., Zhou, Huilin, Field, Seth J.

“…The response to DNA damage, which regulates nuclear processes such as DNA repair, transcription, and cell cycle, has been studied thoroughly. However, the…”
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The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation by Buschman, Matthew D, Bromann, Paul A, Cejudo-Martin, Pilar, Wen, Fang, Pass, Ian, Courtneidge, Sara A

“…Metastatic cancer cells have the ability to both degrade and migrate through the extracellular matrix (ECM). Invasiveness can be correlated with the presence…”
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The GOLPH3 pathway regulates Golgi shape and function and is activated by DNA damage by Buschman, Matthew D, Xing, Mengke, Field, Seth J

“…The Golgi protein GOLPH3 binds to PtdIns(4)P and MYO18A, linking the Golgi to the actin cytoskeleton. The GOLPH3 pathway is essential for vesicular trafficking…”
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GOLPH3L antagonizes GOLPH3 to determine Golgi morphology by Ng, Michelle M, Dippold, Holly C, Buschman, Matthew D, Noakes, Christopher J, Field, Seth J

“…GOLPH3 is a phosphatidylinositol-4-phosphate (PI4P) effector that plays an important role in maintaining Golgi architecture and anterograde trafficking. GOLPH3…”
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Interleukin-15 Enhances Proteasomal Degradation of Bid in Normal Lymphocytes: Implications for Large Granular Lymphocyte Leukemias by HODGE, Deborah L, JUN YANG, LOUGHRAN, Thomas P, YOUNG, Howard A, BUSCHMAN, Matthew D, SCHAUGHENCY, Paul M, HONG DANG, BERE, William, YILI YANG, SAVAN, Ram, SUBLESKI, Jeff J, YIN, Xiao-Ming

“…Large granular lymphocyte (LGL) leukemia is a clonal proliferative disease of T and natural killer (NK) cells. Interleukin (IL)-15 is important for the…”
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The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma by Iizuka, Shinji, Abdullah, Christopher, Buschman, Matthew D, Diaz, Begoña, Courtneidge, Sara A

“…Metastatic cancer cells are characterized by their ability to degrade and invade through extracellular matrix. We previously showed that the Tks adaptor…”
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A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin by Aznar, Nicolas, Sun, Nina, Dunkel, Ying, Ear, Jason, Buschman, Matthew D, Ghosh, Pradipta

“…Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a…”
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MYO18A: An unusual myosin by Buschman, Matthew D., Field, Seth J.

“…MYO18A is a divergent member of the myosin family characterized by the presence of an amino-terminal PDZ domain. MYO18A has been found in a few different…”
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Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction by Akizu, Naiara, Cantagrel, Vincent, Zaki, Maha S, Al-Gazali, Lihadh, Wang, Xin, Rosti, Rasim Ozgur, Dikoglu, Esra, Gelot, Antoinette Bernabe, Rosti, Basak, Vaux, Keith K, Scott, Eric M, Silhavy, Jennifer L, Schroth, Jana, Copeland, Brett, Schaffer, Ashleigh E, Gordts, Philip L S M, Esko, Jeffrey D, Buschman, Matthew D, Field, Seth J, Napolitano, Gennaro, Abdel-Salam, Ghada M, Ozgul, R Koksal, Sagıroglu, Mahmut Samil, Azam, Matloob, Ismail, Samira, Aglan, Mona, Selim, Laila, Mahmoud, Iman G, Abdel-Hadi, Sawsan, Badawy, Amera El, Sadek, Abdelrahim A, Mojahedi, Faezeh, Kayserili, Hulya, Masri, Amira, Bastaki, Laila, Temtamy, Samia, Müller, Ulrich, Desguerre, Isabelle, Casanova, Jean-Laurent, Dursun, Ali, Gunel, Murat, Gabriel, Stacey B, de Lonlay, Pascale, Gleeson, Joseph G

“…Joseph Gleeson and colleagues report that biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy marked by lysosome-autophagosome…”
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IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice by Hodge, Deborah L, Berthet, Cyril, Coppola, Vincenzo, Kastenmüller, Wolfgang, Buschman, Matthew D, Schaughency, Paul M, Shirota, Hidekazu, Scarzello, Anthony J, Subleski, Jeff J, Anver, Miriam R, Ortaldo, John R, Lin, Fanching, Reynolds, Della A, Sanford, Michael E, Kaldis, Philipp, Tessarollo, Lino, Klinman, Dennis M, Young, Howard A

“…Abstract We generated a mouse model with a 162 nt AU-rich element (ARE) region deletion in the 3′ untranslated region (3′UTR) of the interferon-gamma (IFN-γ)…”
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Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis by Edavettal, Suzanne, Cejudo-Martin, Pilar, Dasgupta, Bidisha, Yang, Danlin, Buschman, Matthew D, Domingo, Derrick, Van Kolen, Kristof, Jaiprasat, Pharavee, Gordon, Renata, Schutsky, Keith, Geist, Brian, Taylor, Natalie, Soubrane, Camille Helene, Van Der Helm, Elisabeth, LaCombe, Ann, Ainekulu, Zemeda, Lacy, Eilyn, Aligo, Jason, Ho, Jason, He, Yingbo, Lebowitz, Peter F, Patterson, James T, Scheer, Justin M, Singh, Sanjaya

“…The near impermeability of the blood-brain barrier (BBB) and the unique neuroimmune environment of the CNS prevents the effective use of antibodies in…”
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The proinflammatory cytokine interleukin-18 alters multiple signaling pathways to inhibit natural killer cell death by Hodge, Deborah L, Subleski, Jeff J, Reynolds, Della A, Buschman, Matthew D, Schill, William B, Burkett, Mark W, Malyguine, Anatoli M, Young, Howard A

“…The proinflammatory cytokine, interleukin-18 (IL-18), is a natural killer (NK) cell activator that induces NK cell cytotoxicity and interferon-gamma…”
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Abstract 3155: Tks adaptor proteins and invadopodia formation in the growth and metastasis of melanoma by Iizuka, Shinji, Gould, Christine M., Buschman, Matthew D., Begoña, Diaz, Abdullah, Christopher, Courtneidge, Sara

“…Abstract Invadopodia are actin-based proteolytic structures which facilitate cancer cell invasion and metastasis. While it was previously believed that…”
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