Search Results - "Bus, James"

IARC use of oxidative stress as key mode of action characteristic for facilitating cancer classification: Glyphosate case example illustrating a lack of robustness in interpretative implementation by Bus, James S.

“…The International Agency for Research on Cancer (IARC) has formulated 10 key characteristics of human carcinogens to incorporate mechanistic data into cancer…”
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Analysis of Moms Across America report suggesting bioaccumulation of glyphosate in U.S. mother's breast milk: Implausibility based on inconsistency with available body of glyphosate animal toxicokinetic, human biomonitoring, and physico-chemical data by Bus, James S.

“…The non-peer-reviewed biomonitoring report published online by Moms Across America (MAA; Honeycutt and Rowlands, 2014) does not support the conclusion that…”
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Relevance of mouse lung tumors to human risk assessment by Cohen, Samuel M., Zhongyu, Yan, Bus, James S.

“…Mouse lung is a common site for chemical tumorigenicity, but the relevance to human risk remains debated. Long-term bioassays need to be assessed for…”
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Consideration of Styrene Transcriptomic Data Informs Mouse Lung Cyp2F2-Mediated Adverse Outcome Pathway by Andersen, Melvin E, Bus, James S

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A review of the genotoxicity of the industrial chemical cumene by Gollapudi, B. Bhaskar, Williams, Amy L., Bus, James S.

“…The purpose of this review is to evaluate the literature on the genotoxicity of cumene (CAS # 98−82-8) and to assess the role of mutagenicity, if any, in the…”
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FutureTox: building the road for 21st century toxicology and risk assessment practices by Rowlands, J Craig, Sander, Miriam, Bus, James S

“…This article reports on the outcome of FutureTox, a Society of Toxicology (SOT) Contemporary Concepts in Toxicology (CCT) workshop, whose goal was to address…”
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Cancer Mortality of Workers Exposed to Styrene in the U.S. Reinforced Plastics and Composite Industry by Collins, James J., Bodner, Kenneth M., Bus, James S.

“…Background: Epidemiologic studies have reported increased risk of lymphohematopoietic cancers, lung cancer, and pancreatic cancer after exposure to styrene,…”
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Methyl-tert-butyl ether (MTBE): integration of rat and mouse carcinogenicity data with mode of action and human and rodent bioassay dosimetry and toxicokinetics indicates MTBE is not a plausible human carcinogen by Bus, James S., Gollapudi, B. Bhaskar, Hard, Gordon C.

“…Methyl-tert-butyl ether (MTBE) is a fuel oxygenate used in non-United States geographies. Multiple health reviews conclude that MTBE is not a human-relevant…”
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Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance by Cruzan, George, Bus, James S, Banton, Marcy I, Sarang, Satinder S, Waites, Robbie, Layko, Debra B, Raymond, James, Dodd, Darol, Andersen, Melvin E

“…Styrene is a mouse-specific lung carcinogen, and short-term mode of action studies have demonstrated that cytotoxicity and/or cell proliferation, and genomic…”
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How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data? by Becker, Richard A., Dreier, David A., Manibusan, Mary K., Cox, Louis A. (Tony), Simon, Ted W., Bus, James S.

“…IARC has begun using ToxCast/Tox21 data in efforts to represent key characteristics of carcinogens to organize and weigh mechanistic evidence in cancer hazard…”
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Based on an analysis of mode of action, styrene-induced mouse lung tumors are not a human cancer concern by Cruzan, George, Bus, James S., Andersen, Melvin E., Carlson, Gary P., Banton, Marcy I., Sarang, Satinder S., Waites, Robbie

“…Based on 13 chronic studies, styrene exposure causes lung tumors in mice, but no tumor increases in other organs in mice or rats. Extensive research into the…”
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Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures by Andersen, Melvin E., Cruzan, George, Black, Michael B., Pendse, Salil N., Dodd, Darol, Bus, James S., Sarang, Satinder S., Banton, Marcy I., Waites, Robbie, McMullen, Patrick D.

“…Styrene increased lung tumors in mice at chronic inhalation exposures of 20ppm and greater. MIEs, KEs and MFs were examined using gene expression in three…”
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RE: Knapp DW, Peer WA, Conteh A, Diggs AR, Cooper BR, Glickman NW, et al. Detection of herbicides in the urine of pet dogs following home lawn application. Sci Total Env 2013; 456–457: 34–41 by Bus, James S., Hammond, Larry

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Ethylene Oxide Exposure in U.S. Populations Residing Near Sterilization and Other Industrial Facilities: Context Based on Endogenous and Total Equivalent Concentration Exposures by Sheehan, Patrick J, Lewis, Ryan C, Kirman, Christopher R, Watson, Heather N, Winegar, Eric D, Bus, James S

“…Given ubiquitous human exposure to ethylene oxide (EO), regardless of occupation or geography, the current risk-specific concentrations (RSCs: 0.0001-0.01 ppb)…”
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Toxicity Testing in the 21st Century: A View from the Chemical Industry by Bus, James S., Becker, Richard A.

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Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop by Andersen, Melvin E., Gentry, P. Robinan, Swenberg, James A., Mundt, Kenneth A., White, Kimberly W., Thompson, Chad, Bus, James, Sherman, James H., Greim, Helmut, Bolt, Hermann, Marsh, Gary M., Checkoway, Harvey, Coggon, David, Clewell, Harvey J.

“…Anticipating the need to evaluate and integrate scientific evidence to inform new risk assessments or to update existing risk assessments, the Formaldehyde…”
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Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver by Andersen, Melvin E., Black, Michael B., Campbell, Jerry L., Pendse, Salil N., Clewell III, Harvey J., Pottenger, Lynn H., Bus, James S., Dodd, Darol E., Kemp, Daniel C., McMullen, Patrick D.

“…Dichloromethane (DCM) is a lung and liver carcinogen in mice at inhalation exposures≥2000ppm. The modes of action (MOA) of these responses have been attributed…”
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Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment by Andersen, Melvin E., Cruzan, George, Black, Michael B., Pendse, Salil N., Dodd, Darol E., Bus, James S., Sarang, Satinder S., Banton, Marcy I., Waites, Robbie, Layko, Debra B., McMullen, Patrick D.

“…Both CD-1 and C57BL/6 wildtype (C57BL/6-WT) mice show equivalent short-term lung toxicity from exposures to styrene, while long-term tumor responses are…”
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An F1-extended one-generation reproductive toxicity study in Crl:CD(SD) rats with 2,4-dichlorophenoxyacetic acid by Marty, Mary Sue, Neal, Barbara H, Zablotny, Carol L, Yano, Barry L, Andrus, Amanda K, Woolhiser, Michael R, Boverhof, Darrell R, Saghir, Shakil A, Perala, Adam W, Passage, Julie K, Lawson, Marie A, Bus, James S, Lamb, 4th, James C, Hammond, Larry

“…2,4-Dichlorophenoxyacetic acid (2,4-D) was assessed for systemic toxicity, reproductive toxicity, developmental neurotoxicity (DNT), developmental…”
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Life-stage-, sex-, and dose-dependent dietary toxicokinetics and relationship to toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D) in rats: implications for toxicity test dose selection, design, and interpretation by Saghir, Shakil A, Marty, Mary S, Zablotny, Carol L, Passage, Julie K, Perala, Adam W, Neal, Barbara H, Hammond, Larry, Bus, James S

“…Life-stage-dependent toxicity and dose-dependent toxicokinetics (TK) were evaluated in Sprague Dawley rats following dietary exposure to…”
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