Search Results - "Burzyn, Dalia"

Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature by Stangenberg, Lars, Burzyn, Dalia, Binstadt, Bryce A., Weissleder, Ralph, Mahmood, Umar, Benoist, Christophe, Mathis, Diane

“…Two-way communication between the mammalian nervous and immune systems is increasingly recognized and appreciated. An intriguing example of such crosstalk…”
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842 Exosome mediated reprogramming of tumor associated macrophages by exoASO-STAT6 for the treatment of hepatocellular carcinoma (HCC) by Kamerkar, Sushrut, Leng, Charan, Zhang, Kelvin, Burenkova, Olga, Jang, Su Chul, Kasera, Samuel, Zi, Tong, Economides, Kyriakos, Soos, Timothy, Burzyn, Dalia, Sathyanaryanan, Sriram

“…BackgroundTumor associated macrophages (TAMs) play a critical role in tumor immunosuppression and resistance to immune checkpoint blockade. Reprogramming ‘M2’…”
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703 Engineered exosomes with altered cellular tropism achieve targeted STING agonist delivery and single-agent tumor control in vivo by Kauke, Monique, Ross, Nikki, Burzyn, Dalia, Martin, Shelly, Xu, Ke, Lewis, Nuruddeen, Leng, Charan, Jang, Su Chul, McCoy, Christine, Yu, Stephanie, Dooley, Kevin, Sathyanarayanan, Sriram, Finn, Jonathan

“…BackgroundExosomes are natural, abundant extracellular vesicles capable of transferring complex molecules between neighboring and distant cell types…”
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Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by a Retrovirus by BURZYN, Dalia, RASSA, John C, KIM, David, NEPOMNASCHY, Irene, ROSS, Susan R, PIAZZON, Isabel

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Critical Role of Dendritic Cells in Mouse Mammary Tumor Virus In Vivo Infection by COURREGES, Maria Cecilia, BURZYN, Dalia, NEPOMNASCHY, Irene, PIAZZON, Isabel, ROSS, Susan R

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Regulatory T cells in nonlymphoid tissues by Burzyn, Dalia, Benoist, Christophe, Mathis, Diane

“…Regulatory T (T reg ) cells modulate immune cell responses. Mathis and colleagues review the specialized roles played by tissue-specific Treg cells and reveal…”
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Early Increases in Superantigen-Specific Foxp3+ Regulatory T Cells during Mouse Mammary Tumor Virus Infection by CABRERA, Gabriel, BURZYN, Dalia, MUNDINANO, Juliana, COURREGES, M. Cecilia, CAMICIA, Gabriela, LORENZO, Daniela, COSTA, Héctor, ROSS, Susan R, NEPOMNASCHY, Irene, PIAZZON, Isabel

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Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells by Kuswanto, Wilson, Burzyn, Dalia, Panduro, Marisella, Wang, Kathy K., Jang, Young Charles, Wagers, Amy J., Benoist, Christophe, Mathis, Diane

“…Normal repair of skeletal muscle requires local expansion of a special population of Foxp3+CD4+ regulatory T (Treg) cells. Such cells failed to accumulate in…”
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Individual intestinal symbionts induce a distinct population of RORγ+regulatory T cells by Sefik, Esen, Geva-Zatorsky, Naama, Oh, Sungwhan, Konnikova, Liza, Zemmour, David, McGuire, Abigail Manson, Burzyn, Dalia, Ortiz-Lopez, Adriana, Lobera, Mercedes, Yang, Jianfei, Ghosh, Shomir, Earl, Ashlee, Snapper, Scott B., Jupp, Ray, Kasper, Dennis, Mathis, Diane, Benoist, Christophe

“…T regulatory cells that express the transcription factor Foxp3 (Foxp3+ Tregs) promote tissue homeostasis in several settings. We now report that symbiotic…”
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Binding of natural variants of staphylococcal superantigens SEG and SEI to TCR and MHC class II molecule by Fernández, Marisa M., De Marzi, Mauricio C., Berguer, Paula, Burzyn, Dalia, Langley, Ries J., Piazzon, Isabel, Mariuzza, Roy A., Malchiodi, Emilio L.

“…SEG and SEI are staphylococcal superantigens (SAgs) identified recently that belong to the egc operon and whose genes are in tandem orientation. Only a few…”
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A Special Population of Regulatory T Cells Potentiates Muscle Repair by Burzyn, Dalia, Kuswanto, Wilson, Kolodin, Dmitriy, Shadrach, Jennifer L., Cerletti, Massimiliano, Jang, Young, Sefik, Esen, Tan, Tze Guan, Wagers, Amy J., Benoist, Christophe, Mathis, Diane

“…Long recognized to be potent suppressors of immune responses, Foxp3+CD4+ regulatory T (Treg) cells are being rediscovered as regulators of nonimmunological…”
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A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties by Dooley, Kevin, McConnell, Russell E., Xu, Ke, Lewis, Nuruddeen D., Haupt, Sonya, Youniss, Madeleine R., Martin, Shelly, Sia, Chang Ling, McCoy, Christine, Moniz, Raymond J., Burenkova, Olga, Sanchez-Salazar, Jorge, Jang, Su Chul, Choi, Bryan, Harrison, Rane A., Houde, Damian, Burzyn, Dalia, Leng, Charan, Kirwin, Katherine, Ross, Nikki L., Finn, Jonathan D., Gaidukov, Leonid, Economides, Kyriakos D., Estes, Scott, Thornton, James E., Kulman, John D., Sathyanarayanan, Sriram, Williams, Douglas E.

“…Extracellular vesicles (EVs) are an important intercellular communication system facilitating the transfer of macromolecules between cells. Delivery of…”
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Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity by Kamerkar, Sushrut, Leng, Charan, Burenkova, Olga, Jang, Su Chul, McCoy, Christine, Zhang, Kelvin, Dooley, Kevin, Kasera, Samuel, Zi, Tong, Sisó, Sílvia, Dahlberg, William, Sia, Chang Ling, Patel, Shil, Schmidt, Karl, Economides, Kyriakos, Soos, Timothy, Burzyn, Dalia, Sathyanarayanan, Sriram

“…Effectiveness of checkpoint immunotherapy in cancer can be undermined by immunosuppressive tumor-associated macrophages (TAMs) with an M2 phenotype…”
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Decrease in cAMP levels modulates adhesion to fibronectin and immunostimulatory ability of human dendritic cells by Burzyn, Dalia, Jancic, Carolina C., Zittermann, Sandra, Keller Sarmiento, María I., Fainboim, Leonardo, Rosenstein, Ruth E., Chuluyan, H. Eduardo

“…The aim of the present study was to analyze the early events elicited by tumor necrosis factor α (TNF‐α) on monocyte‐derived dendritic cells (moDC) adhesion to…”
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REGULATORY T CELLS IN NON-LYMPHOID TISSUES by Burzyn, Dalia, Benoist, Christophe, Mathis, Diane

“…Both Foxp3 + CD4 + regulatory T cells (T reg cells) and local immune responses within non-lymphoid tissues have long been recognized as important elements of a…”
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Abstract 1792: Engineered exosome- mediated STAT6 knockdown in tumor associated macrophages (TAMs) results in potent single agent activity in a hepatocellular carcinoma (HCC) model by Kamerkar, Sushrut, Leng, Charan, Burenkova, Olga, Jang, Su Chul, McCoy, Christine, Zhang, Kelvin, Dahlberg, William, Leblanc, Marie, Quillery, Hugo, Maubant, Sylvie, Duchamp, Olivier, Economides, Kyriakos, Soos, Timothy, Burzyn, Dalia, Sathyanarayanan, Sriram

“…Background: Tumor-associated macrophages (TAMs) promote tumor progression and resistance to immune checkpoint inhibitors and are thus attractive targets for…”
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Abstract 5696: Genetic reprogramming of TAMs by engineered exosomes results in potent single agent anti-tumor activity by Kamerkar, Sushrut, Burzyn, Dalia, Burenkova, Olga, Leng, Charan, Yang, Raymond, Kirwin, Katherin, Zi, Tong, Jang, Su Chul, Dahlberg, William, Zhang, Eric, Estes, Scott, Maubant, Sylvie, Duchamp, Olivier, Economides, Kyriakos, Soos, Timothy, Sathyanarayanan, Sriram

“…Background: Tumor-associated macrophages (TAMs) are potent drivers of an immunosuppressive tumor microenvironment by reducing T cell recruitment and…”
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Abstract 3508: Exosome-mediated delivery of antisense oligonucleotides targeting C/EBPβ reprograms tumor-associated macrophages and induces potent single agent anti-tumor activity by Kamerkar, Sushrut, Leng, Charan, Burenkova, Olga, Jang, SuChul, Zhang, Kelvin, Liu, Yanyan, Dahlberg, William, Economides, Kyriakos, Soos, Timothy, Burzyn, Dalia, Sathyanarayanan, Sriram

“…Background: Tumor-associated macrophages (TAMs) and myeloid derived suppressor cells (MDSCs) promote an immunosuppressive milieu by inhibiting T-cell…”
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Individual intestinal symbionts induce a distinct population of ROR[gamma]+ regulatory T cells by Esen Sefik, Geva-Zatorsky, Naama, Oh, Sungwhan, Konnikova, Liza, Zemmour, David, Abigail Manson McGuire, Burzyn, Dalia, Ortiz-Lopez, Adriana, Lobera, Mercedes, Yang, Jianfei, Ghosh, Shomir, Earl, Ashlee, Snapper, Scott B, Jupp, Ray, Kasper, Dennis, Mathis, Diane

“…Our guts harbor trillions of microbial inhabitants, some of which regulate the types of immune cells that are present in the gut. For instance, Clostridium…”
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Cathepsin-L Influences the Expression of Extracellular Matrix in Lymphoid Organs and Plays a Role in the Regulation of Thymic Output and of Peripheral T Cell Number by Lombardi, Gabriela, Burzyn, Dalia, Mundinano, Juliana, Berguer, Paula, Bekinschtein, Pedro, Costa, Hector, Castillo, Lilian Fedra, Goldman, Alejandra, Meiss, Roberto, Piazzon, Isabel, Nepomnaschy, Irene

“…Nackt mice, which are deficient in cathepsin-L (CTSL), show an early impairment during positive selection in the context of class II MHC molecules and as a…”
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