Search Results - "Burwinkel, B."

Circulating miRNAs: cell-cell communication function? by Turchinovich, A, Samatov, T R, Tonevitsky, A G, Burwinkel, B

“…Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable;…”
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Inhibition of Id proteins by a peptide aptamer induces cell-cycle arrest and apoptosis in ovarian cancer cells by Mern, D S, Hasskarl, J, Burwinkel, B

“…Background: Inhibitors of DNA-binding proteins (Id1-4), lacking the basic DNA-binding domain, function as dominant inhibitors of cell-cycle regulators…”
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Circulating microRNA's as a diagnostic tool for hepatocellular carcinoma in a hyper endemic HIV setting, KwaZulu-Natal, South Africa: a case control study protocol focusing on viral etiology by Sartorius, K, Sartorius, B, Kramvis, A, Singh, E, Turchinovich, A, Burwinkel, B, Madiba, T, Winkler, C A

“…A wide range of studies has investigated the diagnostic proficiency of extracellular microRNAs (miRNAs) in hepatocellular cancer (HCC). HCC is expected to…”
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Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts by Ek, Weronica E, Reznichenko, Anna, Ripke, Stephan, Niesler, Beate, Zucchelli, Marco, Rivera, Natalia V, Schmidt, Peter T, Pedersen, Nancy L, Magnusson, Patrik, Talley, Nicholas J, Holliday, Elizabeth G, Houghton, Lesley, Gazouli, Maria, Karamanolis, George, Rappold, Gudrun, Burwinkel, Barbara, Surowy, Harald, Rafter, Joseph, Assadi, Ghazaleh, Li, Ling, Papadaki, Evangelia, Gambaccini, Dario, Marchi, Santino, Colucci, Rocchina, Blandizzi, Corrado, Barbaro, Raffaella, Karling, Pontus, Walter, Susanna, Ohlsson, Bodil, Tornblom, Hans, Bresso, Francesca, Andreasson, Anna, Dlugosz, Aldona, Simren, Magnus, Agreus, Lars, Lindberg, Greger, Boeckxstaens, Guy, Bellini, Massimo, Stanghellini, Vincenzo, Barbara, Giovanni, Daly, Mark J, Camilleri, Michael, Wouters, Mira M, D'Amato, Mauro

“…IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by…”
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Interference in transcription of overexpressed genes by promoter-proximal downstream sequences by Turchinovich, A., Surowy, H. M., Tonevitsky, A. G., Burwinkel, B.

“…Despite a high sequence homology among four human RNAi-effectors Argonaute proteins and their coding sequences, the efficiency of ectopic overexpression of…”
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miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome by Wohlfarth, Carolin, Schmitteckert, Stefanie, Härtle, Janina D., Houghton, Lesley A., Dweep, Harsh, Fortea, Marina, Assadi, Ghazaleh, Braun, Alexander, Mederer, Tanja, Pöhner, Sarina, Becker, Philip P., Fischer, Christine, Granzow, Martin, Mönnikes, Hubert, Mayer, Emeran A., Sayuk, Gregory, Boeckxstaens, Guy, Wouters, Mira M., Simrén, Magnus, Lindberg, Greger, Ohlsson, Bodil, Schmidt, Peter Thelin, Dlugosz, Aldona, Agreus, Lars, Andreasson, Anna, D’Amato, Mauro, Burwinkel, Barbara, Bermejo, Justo Lorenzo, Röth, Ralph, Lasitschka, Felix, Vicario, Maria, Metzger, Marco, Santos, Javier, Rappold, Gudrun A., Martinez, Cristina, Niesler, Beate

“…Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT 4 receptors are promising…”
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Plasma miRNAs as prognostic markers in colorectal cancer by Maierthaler, M, Benner, A, Jansen, L, Knebel, P, Chang-Claude, J, Hoffmeister, M, Brenner, H, Burwinkel, B

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Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study by GAST, A, BERMEJO, J. L, FLOHR, T, STANULLA, M, BURWINKEL, B, SCHRAPPE, M, BARTRAM, C. R, HEMMINKI, K, KUMAR, R

“…We genotyped six folate metabolic pathway genes for 11 polymorphisms in 460 cases of childhood acute lymphoblastic leukemia (ALL) and 552 ethnically matched…”
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FGFR4 Arg388 genotype is associated with pathological complete response to neoadjuvant chemotherapy for primary breast cancer by Marmé, F., Werft, W., Benner, A., Burwinkel, B., Sinn, P., Sohn, C., Lichter, P., Hahn, M., Schneeweiss, A.

“…A single-nucleotide polymorphism (SNP) in the FGFR4 gene is associated with poor prognosis in solid tumors. A recent study presented the first evidence that…”
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Genetic variants in DNA repair genes as potential predictive markers for oxaliplatin chemotherapy in colorectal cancer by Kap, E J, Seibold, P, Richter, S, Scherer, D, Habermann, N, Balavarca, Y, Jansen, L, Becker, N, Pfütze, K, Popanda, O, Hoffmeister, M, Ulrich, A, Benner, A, Ulrich, C M, Burwinkel, B, Brenner, H, Chang-Claude, J

“…Oxaliplatin-based chemotherapy exerts its effects through generating DNA damage. Hence, genetic variants in DNA repair pathways could modulate treatment…”
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Chromosome copy number variation and breast cancer risk by Tchatchou, S, Burwinkel, B

“…Breast cancer is the most frequent cancer among women. It is caused by genetic and environmental factors. Whereas mutations in high-penetrance susceptibility…”
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847 Identification of a Biomarker Signature to Predict the Need for Chemotherapy in Patients With Hormone Receptor Positive Breast Cancer by Korf, U, Sonntag, J, Bender, C, Wiemann, S, Aulmann, S, Sinn, P, Burwinkel, B, Schneeweiss, A, Beissbarth, T

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291 Comparison of Conventional Cell Lines and Improved Models for Ovarian Carcinoma – Drug Targets and Cancer-stem Cell Markers by Wagner, S, Schillert, A, Burwinkel, B, Klein, C, Vogel, V, Weichert, W, Schirmacher, P, Sprick, M, Trumpp, A

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Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer by Wirtenberger, Michael, Tchatchou, Sandrine, Hemminki, Kari, Schmutzhard, Julia, Sutter, Christian, Schmutzler, Rita K., Meindl, Alfons, Wappenschmidt, Barbara, Kiechle, Marion, Arnold, Norbert, Weber, Bernhard H. F., Niederacher, Dieter, Bartram, Claus R., Burwinkel, Barbara

“…The mitogen effect of the ovarian steroid estrogen is a strong risk factor for breast cancer development. This effect is mainly mediated by the estrogen…”
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The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer by Wirtenberger, Michael, Schmutzhard, Julia, Hemminki, Kari, Meindl, Alfons, Sutter, Christian, Schmutzler, Rita K., Wappenschmidt, Barbara, Kiechle, Marion, Arnold, Norbert, Weber, Bernhard H.F., Niederacher, Dieter, Bartram, Claus R., Burwinkel, Barbara

“…Overexpression of cAMP-dependent protein kinase A (PKA) is a hallmark of the great majority of human cancers including breast cancer. A-kinase anchoring…”
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A BRCA1 promoter variant (rs11655505) and breast cancer risk by Verderio, Paolo, Pizzamiglio, Sara, Southey, Melissa C, Spurdle, Amanda B, Hopper, John L, Chen, Xiaoqing, Beesley, Jonathan, Schmutzler, Rita K, Engel, Christoph, Burwinkel, Barbara, Bugert, Peter, Ficarazzi, Filomena, Manoukian, Siranoush, Barile, Monica, Wappenschmidt, Barbara, Chenevix-Trench, Georgia, Radice, Paolo, Peterlongo, Paolo

“…A study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.-2265C-->T) increases promoter activity and has a…”
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miRNA-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in Irritable Bowel Syndrome (IBS) by Schmitteckert, S, Wohlfarth, C, Hartle, JD, Houghton, L, Dweep, H, Fortea, M, Ghazaleh, A, Braun, A, Mederer, T, Sarina, P, Becker, PP, Fischer, C, Granzow, M, Monnikes, H, Mayer, EA, Sayuk, G, Boeckxstaens, G, Wouters, M, Simren, M, Lindberg, G, Ohlsson, B, Schmidt, PT, Dlugosz, A, Agreus, L, Andreasson, A, D'Amato, M, Burwinkel, B, Lorenzo, J, Roth, R, Lastischka, F, Vicario, M, Metzger, M, Santos, J, Rappold, GA, Martinez, C, Niesler, B

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Genetic susceptibility to pancreatic cancer and its functional characterization: The PANcreatic Disease ReseArch (PANDoRA) consortium by Canzian, F, Rizzato, C, Werner, J, Capurso, G, Greenhalf, W, Talar-Wojnarowska, R, Jamroziak, K, Pezzilli, R, Imbrogno, A, Delle Fave, G, Costello, E, Khaw, K.T, Key, T.J, Siddiq, A, Burwinkel, B, Landi, S, Neoptolemos, J.P, Bugert, P, Vodicka, P, Soucek, P, Büchler, M.W, Giese, N, Campa, D

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Gene-wide association study on the TERT locus and PDAC susceptibility – Results from the PANDoRA consortium by Campa, D, Rizzato, C, Werner, J, Capurso, G, Greenhalf, W, Talar-Wojnarowska, R, Jamroziak, K, Pezzilli, Imbrogno, A, Valente, R, Costello, E, Khaw, K.T, Key, T.J, Siddiq, A, Burwinkel, B, Landi, S, Neoptolemos, J.P, Bugert, P, Vodicka, P, Soucek, P, Büchler, M.W, Giese, N, Canzian, F

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Genetic susceptibility to pancreatic cancer and its functional characterization: The PANcreatic Disease ReseArch (PANDoRA) consortium by Canzian, F, Rizzato, C, Werner, J, Capurso, G, Greenhalf, W, Talar-Wojnarowska, R, Jamroziak, K, Pezzilli, R, Imbrogno, A, Delle Fave, G, Costello, E, Khaw, K.T, Key, T.J, Siddiq, A, Burwinkel, B, Landi, S, Neoptolemos, J.P, Bugert, P, Vodicka, P, Soucek, P, Büchler, M.W, Giese, N, Campa, D

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