Search Results - "Burton, Jack D."

CD74 Is Expressed by Multiple Myeloma and Is a Promising Target for Therapy by BURTON, Jack D, ELY, Scott, REDDY, Praveen K, STEIN, Rhona, GOLD, David V, CARDILLO, Thomas M, GOLDENBERG, David M

“…Purpose: CD74 (HLA-DR-associated invariant chain) plays a role in antigen presentation. In addition to its expression on antigen-presenting cells, it is…”
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Potential of Peroxisome Proliferator-Activated Receptor Gamma Antagonist Compounds as Therapeutic Agents for a Wide Range of Cancer Types by Burton, Jack D., Goldenberg, David M., Blumenthal, Rosalyn D.

“…PPARγ is a therapeutic target that has been exploited for treatment of type II diabetes mellitus (T2DM) with agonist drugs. Since PPARγ is expressed by many…”
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The MTT assay to evaluate chemosensitivity by Burton, Jack D

“…The assessment of the degree or rate of cellular proliferation and cell viability is critical to the assessment of the effects of drugs, antibodies, or…”
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Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells by Tagaya, Yutaka, Burton, Jack D, Miyamoto, Yoshihisa, Waldmann, Thomas A

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Peroxisome proliferator-activated receptor-γ antagonists exhibit potent antiproliferative effects versus many hematopoietic and epithelial cancer cell lines by Burton, Jack D, Castillo, Mary E, Goldenberg, David M, Blumenthal, Rosalyn D

“…Peroxisome proliferator-activated receptor-γ ligands have preclinical and clinical anticancer activity. Most studies in this area address agonists, with…”
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New agents and approaches to the treatment of B-cell non-Hodgkin lymphoma by Burton, Jack D, Goldenberg, David M

“…B-cell non-Hodgkin lymphoma (NHL) is a significant public health problem as the most common hematologic malignancy in many areas of the world. Current…”
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Interleukin (IL) 15/IL-T Production by the Adult T-Cell Leukemia Cell Line HuT-102 is Associated with a Human T-Cell Lymphotrophic Virus Type I R Region/IL-15 Fusion Message that Lacks Many Upstream AUGs that Normally Attenuate IL-15 mRNA Translation by Bamford, Richard N., Battiata, Andrew P., Burton, Jack D., Sharma, Harmesh, Waldmann, Thomas A.

“…We reported previously that the human T-cell lymphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia line HuT-102 produces a cytokine designated…”
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A Lymphokine, Provisionally Designated Interleukin T and Produced by a Human Adult T-Cell Leukemia Line, Stimulates T-Cell Proliferation and the Induction of Lymphokine-Activated Killer Cells by Burton, Jack D., Bamford, Richard N., Peters, Christian, Grant, Angus J., Kurys, Gloria, Goldman, Carolyn K., Brennan, Jennifer, Roessler, Erich, Waldmann, Thomas A.

“…In early phases of human T-cell lymphotropic virus I-induced adult T-cell leukemia (ATL), the malignant cell proliferation is associated with an autocrine…”
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Ibuprofen-associated pure white-cell aplasia by Mamus, S W, Burton, J D, Groat, J D, Schulte, D A, Lobell, M, Zanjani, E D

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Abnormal cytokine expression in Sézary and adult T-cell leukemia cells correlates with the functional diversity between these T-cell malignancies by TENDLER, C. L, BURTON, J. D, JAFFE, J, DANIELPOUR, D, CHARLEY, M, MCCOY, J. P, PITTELKOW, M. R, WALDMANN, T. A

“…The Sézary syndrome (SzS) and adult T-cell leukemia (ATL) are malignant proliferations of mature T-lymphocytes that possess distinct functions. Sézary cells…”
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Erratum To: Identification of a novel receptor/signal transduction pathway for IL‐15/T in mast cells by Tagaya, Yutaka, Burton, Jack D, Miyamoto, Yoshihisa, Waldmann, Thomas A

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The Interleukin (IL) 2 Receptor β Chain is Shared by IL-2 and a Cytokine, Provisionally Designated IL-T, That Stimulates T-Cell Proliferation and the Induction of Lymphokine-Activated Killer Cells by Bamford, Richard N., Grant, Angus J., Burton, Jack D., Peters, Christian, Kurys, Gloria, Goldman, Carolyn K., Brennan, Jennifer, Roessler, Erich, Waldman, Thomas A.

“…Late-phase human T-cell lymphotropic virus I-associated adult T-cell leukemia cells express IL-2 receptors (IL-2R) but no longer produce IL-2. We have reported…”
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Identification of a novel receptor/signal transduction pathway for IL‐15/T in mast cells by Tagaya, Y., Burton, J. D., Miyamoto, Y., Waldmann, T. A.

“…Interleukin‐15/T(IL‐15) is a growth factor that utilizes IL‐2 receptor (IL‐2R) components in addition to its private binding protein IL‐15R(alpha) in T‐cells…”
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Transactivation of Interleukin 2 and Its Receptor Induces Immune Activation in Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy: Pathogenic Implications and a Rationale for Immunotherapy by Tendler, Craig L., Greenberg, Steven J., Blattner, William A., Manns, Angela, Murphy, Edward, Fleisher, Thomas, Hanchard, Barrie, Morgan, Owen, Burton, Jack D., Nelson, David L., Waldmann, Thomas A.

“…A state of T-cell activation, reflected by a marked degree of spontaneous proliferation in vitro, exists among patients with human T-cell lymphotropic virus…”
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Cytokine induction in HTLV-I associated myelopathy and adult T-cell leukemia: alternate molecular mechanisms underlying retroviral pathogenesis by Tendler, C L, Greenberg, S J, Burton, J D, Danielpour, D, Kim, S J, Blattner, W A, Manns, A, Waldmann, T A

“…The human T-cell lymphotropic virus type I (HTLV-I) is capable of inducing a variety of host cellular genes including many of the cytokines responsible for…”
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The interleukin (IL) 2 receptor (beta) chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells by Bamford, Richard N, Grant, Angus J, Burton, Jack D, Peters, Christian

“…It is shown that the interleukin-T-mediated stimulation of cytokine-dependent T-cell line or the activation of large granular lymphocytes is not blocked by the…”
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Malignant chronic lymphocytic leukemia B cells elaborate soluble factors that down-regulate T cell and NK function by Burton, J D, Weitz, C H, Kay, N E

“…To determine if the frequently observed T cell and natural killer dysfunction in B-chronic lymphocytic leukemia might be related to the presence of large…”
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Human B lymphocytes express the p75 component of the interleukin 2 receptor by Begley, C G, Burton, J D, Tsudo, M, Brownstein, B H, Ambrus, Jr, J L, Waldmann, T A

“…The nature of the interleukin 2 (IL-2) receptor on purified human B lymphocytes was examined. Both normal and malignant cells showed evidence of a 70-75,000…”
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