Search Results - "Burton, Francis L."

Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin β Receptors by Hu, Desheng, Mohanta, Sarajo K., Yin, Changjun, Peng, Li, Ma, Zhe, Srikakulapu, Prasad, Grassia, Gianluca, MacRitchie, Neil, Dever, Gary, Gordon, Peter, Burton, Francis L., Ialenti, Armando, Sabir, Suleman R., McInnes, Iain B., Brewer, James M., Garside, Paul, Weber, Christian, Lehmann, Thomas, Teupser, Daniel, Habenicht, Livia, Beer, Michael, Grabner, Rolf, Maffia, Pasquale, Weih, Falk, Habenicht, Andreas J.R.

“…Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in…”
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Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes by Saleem, Umber, van Meer, Berend J, Katili, Puspita A, Mohd Yusof, Nurul A N, Mannhardt, Ingra, Garcia, Ana Krotenberg, Tertoolen, Leon, de Korte, Tessa, Vlaming, Maria L H, McGlynn, Karen, Nebel, Jessica, Bahinski, Anthony, Harris, Kate, Rossman, Eric, Xu, Xiaoping, Burton, Francis L, Smith, Godfrey L, Clements, Peter, Mummery, Christine L, Eschenhagen, Thomas, Hansen, Arne, Denning, Chris

“…Abstract Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced…”
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Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies by Main, Alice, Boguslavskyi, Andri, Howie, Jacqueline, Kuo, Chien-Wen, Rankin, Aileen, Burton, Francis L, Smith, Godfrey L, Hajjar, Roger, Baillie, George S, Campbell, Kenneth S, Shattock, Michael J, Fuller, William

“…S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in…”
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Electrophysiology of hiPSC-Cardiomyocytes Co-Cultured with HEK Cells Expressing the Inward Rectifier Channel by Costa, Ana Da Silva, Mortensen, Peter, Hortigon-Vinagre, Maria P., van der Heyden, Marcel A. G., Burton, Francis L., Gao, Hao, Simitev, Radostin D., Smith, Godfrey L.

“…The immature electrophysiology of human-induced pluripotent stem cell-derived cardiomyocytes (hiCMs) complicates their use for therapeutic and pharmacological…”
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Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation by Kohl, Peter, Camelliti, Patrizia, Burton, Francis L., Smith, Godfrey L.

“…Myocytes, while giving rise to the bulk volume of normal cardiac muscle, form a “minority cell population” in the heart compared with nonmyocytes, chiefly…”
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MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo by Sala, Luca, van Meer, Berend J, Tertoolen, Leon G.J, Bakkers, Jeroen, Bellin, Milena, Davis, Richard P, Denning, Chris, Dieben, Michel A.E, Eschenhagen, Thomas, Giacomelli, Elisa, Grandela, Catarina, Hansen, Arne, Holman, Eduard R, Jongbloed, Monique R.M, Kamel, Sarah M, Koopman, Charlotte D, Lachaud, Quentin, Mannhardt, Ingra, Mol, Mervyn P.H, Mosqueira, Diogo, Orlova, Valeria V, Passier, Robert, Ribeiro, Marcelo C, Saleem, Umber, Smith, Godfrey L, Burton, Francis L, Mummery, Christine L

“…RATIONALE:There are several methods to measure cardiomyocyte and muscle contraction, but these require customized hardware, expensive apparatus, and advanced…”
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Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes by Lachaud, Quentin, Aziz, Muhamad Hifzhudin Noor, Burton, Francis L, Macquaide, Niall, Myles, Rachel C, Simitev, Radostin D, Smith, Godfrey L

“…Cardiac electrophysiological heterogeneity includes: (i) regional differences in action potential (AP) waveform, (ii) AP waveform differences in cells isolated…”
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Initiation of ventricular arrhythmia in the acquired long QT syndrome by Alexander, Cherry, Bishop, Martin J, Gilchrist, Rebecca J, Burton, Francis L, Smith, Godfrey L, Myles, Rachel C

“…Long QT syndrome (LQTS) carries a risk of life-threatening polymorphic ventricular tachycardia (Torsades de Pointes, TdP) and is a major cause of premature…”
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A comprehensive protocol combining in vivo and ex vivo electrophysiological experiments in an arrhythmogenic animal model by Nyman, Mathias, Stølen, Tomas O, Johnsen, Anne Berit, Garten, Karin, Burton, Francis L, Smith, Godfrey L, Loennechen, Jan Pål

“…Ventricular arrhythmias contribute significantly to cardiovascular mortality, with coronary artery disease as the predominant underlying cause. Understanding…”
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Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell‐derived cardiomyocytes by Huethorst, Eline, Mortensen, Peter, Simitev, Radostin D., Gao, Hao, Pohjolainen, Lotta, Talman, Virpi, Ruskoaho, Heikki, Burton, Francis L., Gadegaard, Nikolaj, Smith, Godfrey L.

“…Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) in monolayers interact mechanically via cell–cell and cell–substrate adhesion…”
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Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive? by de Korte, Tessa, Katili, Puspita A, Mohd Yusof, Nurul A.N, van Meer, Berend J, Saleem, Umber, Burton, Francis L, Smith, Godfrey L, Clements, Peter, Mummery, Christine L, Eschenhagen, Thomas, Hansen, Arne, Denning, Chris

“…In recent decades, drug development costs have increased by approximately a hundredfold, and yet about 1 in 7 licensed drugs are withdrawn from the market,…”
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Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarizations, and fibrillation by Kettlewell, Sarah, Burton, Francis L, Smith, Godfrey L, Workman, Antony J

“…Atrial fibrillation (AF) is increased in patients with heart failure resulting from myocardial infarction (MI). We aimed to determine the effects of chronic…”
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The Use of Voltage Sensitive Dye di-4-ANEPPS and Video-Based Contractility Measurements to Assess Drug Effects on Excitation–Contraction Coupling in Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes by Hortigon-Vinagre, Maria Pura, Zamora, Victor, Burton, Francis L., Smith, Godfrey L.

“…ABSTRACTSince cardiotoxicity is one of the leading causes of drug failure and attrition, the design of new protocols and technologies to assess pro-arrhythmic…”
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Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: Role of fibrosis and connexin remodelling by Nisbet, Ashley M., Camelliti, Patrizia, Walker, Nicola L., Burton, Francis L., Cobbe, Stuart M., Kohl, Peter, Smith, Godfrey L.

“…Conduction abnormalities are frequently associated with cardiac disease, though the mechanisms underlying the commonly associated increases in PQ interval are…”
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Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations by Di Diego, José M, Sicouri, Serge, Myles, Rachel C, Burton, Francis L, Smith, Godfrey L, Antzelevitch, Charles

“…Abstract The electrophysiological heterogeneity that exists across the ventricular wall in the mammalian heart has long been recognized, but remains an area…”
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Effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium by Myles, Rachel C, Bernus, Olivier, Burton, Francis L, Cobbe, Stuart M, Smith, Godfrey L

“…Although transmural heterogeneity of action potential duration (APD) is established in single cells isolated from different tissue layers, the extent to which…”
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Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction by Myles, Rachel C, Burton, Francis L, Cobbe, Stuart M, Smith, Godfrey L

“…Abstract T-wave alternans may predict the occurrence of ventricular arrhythmias in patients with left ventricular dysfunction and experimental work has linked…”
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2-Photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca(2+) in intact mice, rat, and rabbit hearts by Ghouri, Iffath A, Kelly, Allen, Burton, Francis L, Smith, Godfrey L, Kemi, Ole Johan

“…We describe a novel two-photon (2P) laser scanning microscopy (2PLSM) protocol that provides ratiometric transmural measurements of membrane voltage (Vm ) via…”
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2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+ in intact mice, rat, and rabbit hearts by Ghouri, Iffath A., Kelly, Allen, Burton, Francis L., Smith, Godfrey L., Kemi, Ole Johan

“…We describe a novel two‐photon (2P) laser scanning microscopy (2PLSM) protocol that provides ratiometric transmural measurements of membrane voltage (Vm) via…”
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Subepicardial Action Potential Characteristics Are a Function of Depth and Activation Sequence in Isolated Rabbit Hearts by Kelly, Allen, Ghouri, Iffath A., Kemi, Ole J., Bishop, Martin J., Bernus, Olivier, Fenton, Flavio H., Myles, Rachel C., Burton, Francis L., Smith, Godfrey L.

“…BACKGROUND—Electric excitability in the ventricular wall is influenced by cellular electrophysiology and passive electric properties of the myocardium. Action…”
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