Search Results - "Burton, Earl G"
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Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5
Published in Drug metabolism and disposition (01-12-2002)“…In vitro studies were conducted to identify the major metabolites of eplerenone (EP) and the cytochrome P450 (P450) isozymes involved in its primary oxidative…”
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2
Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)
Published in Journal of medicinal chemistry (25-04-1997)“…A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and…”
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3
1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents
Published in Journal of medicinal chemistry (01-10-1995)Get full text
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4
Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Celecoxib in Rats
Published in Drug metabolism and disposition (01-05-2000)“…The pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1 H -pyrazol-1-yl]…”
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5
Evidence for Polymorphism in the Canine Metabolism of the Cyclooxygenase 2 Inhibitor, Celecoxib
Published in Drug metabolism and disposition (01-10-1999)“…The pharmacokinetics of celecoxib, a cyclooxygenase-2 inhibitor, was characterized in beagle dogs. Celecoxib is extensively metabolized by dogs to a…”
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6
Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors: Synthesis and Structure−Activity Relationships
Published in Journal of medicinal chemistry (05-01-1996)“…A novel series of 5,6-diarylspiro[2.4]hept-5-enes was shown to provide highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. A study of…”
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7
Properties of Repressible Alkaline Phosphatase from Wild Type and a Wall-less Mutant of Neurospora crassa
Published in The Journal of biological chemistry (10-08-1974)“…The repressible alkaline phosphatase of Neurospora crassa was purified from both the mycelium of a wild type strain and from the medium in which cultures of…”
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8
Novel mutation causing derepression of several enzymes of sulfur metabolism in Neurospora crassa
Published in Journal of Bacteriology (1972)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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9
Aryl Sulfatase in Ascospores of Neurospora crassa
Published in Journal of Bacteriology (01-01-1973)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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10
Plasma protein binding of celecoxib in mice, rat, rabbit, dog and human
Published in Biopharmaceutics & drug disposition (01-09-1999)“…The plasma protein binding of celecoxib was determined for animals and humans using in vitro and ex vivo methods. Eight, healthy, human volunteers (three male,…”
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Identification of N-beta-L-aspartyl-L-phenylalanine as a normal constituent of human plasma and urine
Published in The Journal of nutrition (01-05-1989)“…A new beta-aspartyl dipeptide, N-beta-L-aspartyl-L-phenylalanine (beta-AP), has been isolated and identified in urine and plasma from normal human volunteers…”
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Absorption by the rhesus monkey of phenylalanine methyl ester and species differences in its metabolism by blood, plasma and intestinal mucosa
Published in The Journal of nutrition (01-10-1984)“…Phenylalanine methyl ester (PM) is a decomposition product of the sweetening agent aspartame. The potential for absorption of PM was examined following…”
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Methylenetetrahydrofolate reductase in the rat central nervous system: intracellular and regional distribution
Published in Archives of biochemistry and biophysics (01-01-1975)Get more information
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