Search Results - "Burtner, Christopher"

Progeria syndromes and ageing: what is the connection? by Kennedy, Brian K, Burtner, Christopher R

“…Key Points Despite decades of research, the extent to which human progerias resemble accelerated ageing is still unclear and highly debated. To understand this…”
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Recent developments in yeast aging by Kaeberlein, Matt, Burtner, Christopher R, Kennedy, Brian K

“…In the last decade, research into the molecular determinants of aging has progressed rapidly and much of this progress can be attributed to studies in…”
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A molecular mechanism of chronological aging in yeast by Burtner, Christopher R., Murakami, Christopher J., Kennedy, Brian K., Kaeberlein, Matt

“…The molecular mechanisms that cause organismal aging are a topic of intense scrutiny and debate.  Dietary restriction extends the life span of many organisms,…”
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A genomic analysis of chronological longevity factors in budding yeast by Burtner, Christopher R., Murakami, Christopher J., Olsen, Brady, Kennedy, Brian K., Kaeberlein, Matt

“…Chronological life span (CLS) has been studied as an aging paradigm in yeast. A few conserved aging genes have been identified that modulate both chronological…”
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Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53 by Kudlow, Brian A, Stanfel, Monique N, Burtner, Christopher R, Johnston, Elijah D, Kennedy, Brian K

“…Hutchinson-Gilford progeria syndrome (HGPS) is a rare, debilitating disease with early mortality and rapid onset of aging-associated pathologies. It is linked…”
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Intravenous injection of a foamy virus vector to correct canine SCID-X1 by Burtner, Christopher R., Beard, Brian C., Kennedy, Douglas R., Wohlfahrt, Martin E., Adair, Jennifer E., Trobridge, Grant D., Scharenberg, Andrew M., Torgerson, Troy R., Rawlings, David J., Felsburg, Peter J., Kiem, Hans-Peter

“…Current approaches to hematopoietic stem cell (HSC) gene therapy involve the collection and ex vivo manipulation of HSCs, a process associated with loss of…”
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Bridging the Divide: Student Grand Rounds at the Interface of Basic Science and Clinical Medicine by Hollenhorst, Marie A, Braun, David A, Burtner, Christopher R, Cajigas, Iahn, Cunningham-Bussel, Amy C, Eser, Pinar Ö, Nabel, Christopher S, Tsai, Frederick D, Weeks, Lachelle D, Michel, Thomas, Yialamas, Maria A

“…PROBLEMAs biomedical research and clinical medicine become increasingly complex, physician–scientists and clinically oriented biomedical researchers play…”
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A Method for High-Throughput Quantitative Analysis of Yeast Chronological Life Span by Murakami, Christopher J., Burtner, Christopher R., Kennedy, Brian K., Kaeberlein, Matt

“…Chronological aging in yeast has been studied by maintaining cells in a quiescent-like stationary phase culture and monitoring cell survival over time. The…”
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(211)Astatine-Conjugated Monoclonal CD45 Antibody-Based Nonmyeloablative Conditioning for Stem Cell Gene Therapy by Burtner, Christopher R, Chandrasekaran, Devikha, Santos, Erlinda B, Beard, Brian C, Adair, Jennifer E, Hamlin, Donald K, Wilbur, D Scott, Sandmaier, Brenda M, Kiem, Hans-Peter

“…Most hematopoietic stem cell gene therapy studies require host conditioning to allow for efficient engraftment of gene-modified cells. Conditioning regimens…”
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Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy by Humbert, Olivier, Chan, Frieda, Rajawat, Yogendra S., Torgerson, Troy R., Burtner, Christopher R., Hubbard, Nicholas W., Humphrys, Daniel, Norgaard, Zachary K., O'Donnell, Patricia, Adair, Jennifer E., Trobridge, Grant D., Scharenberg, Andrew M., Felsburg, Peter J., Rawlings, David J., Kiem, Hans-Peter

“…Hematopoietic stem-cell gene therapy is a promising treatment of X-linked severe combined immunodeficiency disease (SCID-X1), but currently, it requires…”
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Pigtailed macaques as a model to study long-term safety of lentivirus vector-mediated gene therapy for hemoglobinopathies by Kiem, Hans-Peter, Arumugam, Paritha I, Burtner, Christopher R, Fox, Catherine F, Beard, Brian C, Dexheimer, Phillip, Adair, Jennifer E, Malik, Punam

“…Safely achieving long-term engraftment of genetically modified hematopoietic stem cells (HSCs) that maintain therapeutic transgene expression is the benchmark…”
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A genomic approach to yeast chronological aging by Burtner, Christopher R, Murakami, Christopher J, Kaeberlein, Matt

“…Yeast is a useful model organism to study the genetic and biochemical mechanisms of aging. Genomic studies of aging in yeast have been limited, however, by…”
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Maintenance of Leukocyte Telomere Length after Transplant and Chemoselection in Macaques with Polyclonal Gene Modified Cell Engraftment by Adair, Jennifer E, Burtner, Christopher R, Kiem, Hans-Peter

“…Hematopoietic stem and progenitor cell (HSPC) gene therapy relies on stable therapeutic levels of gene-modified HSC engraftment. The variant methylguanine…”
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242. Leukocyte Telomere Length Is Maintained Following Transplant and Chemoselection in Macaques with Polyclonal Engraftment of Gene Modified Blood Cells by Burtner, Christopher R., Kibui, Julie, Kiem, Hans-Peter, Adair, Jennifer E.

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284. Long-Term Therapeutic Immune Reconstitution in XSCID Canine Model via In Vivo Foamy Virus Delivery of Common Gamma Chain by Chan, Frieda, Humbert, Olivier, Burtner, Christopher, Humphrys, Daniel, Adair, Jennifer, Trobridge, Grant, O'Donnell, Patricia, Hubbard, Nicholas, Torgerson, Troy, Scharenberg, Andrew, Rawlings, David, Felsburg, Peter J., Kiem, Hans-Peter

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Safety Of a Gamma Globin Expressing Lentivirus Vector In a Non-Human Primate Model For Gene Therapy Of Sickle Cell Disease by Kiem, Hans-Peter, Arumugam, Paritha, Christopher, Burtner, Adair, Jennifer E, Beard, Brian C, Fox, Catherine, Malik, Punam

“…Strategies for human gene therapy trials targeting hematopoietic stem cells (HSCs) are complicated by studies in murine models due to differences in stem cell…”
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Pgk-Mediated Expression of Common Gamma Chain Is More Effective Than EF1a for Therapeutic Immune Reconstitution of X-SCID Dogs after In Vivo Gene Therapy with Foamy Virus Vector by Humbert, Olivier, Burtner, Christopher R, O'Donnell, Patricia, Humphrys, Daniel R, Hubbard, Nicholas, Chan, Frieda, Adair, Jennifer E, Trobridge, Grant D., Torgerson, Troy, Scharenberg, Andrew M., Rawlings, David J., Felsburg, Peter, Kiem, Hans-Peter

“…In vivo gene therapy has several benefits over ex vivo hematopoietic stem cell gene therapy, including the correction of progenitor cells in their native…”
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Robust Therapeutic Expression of the Common Gamma Chain with the Human Pgk Promoter Using Foamy Virus in Vivo Gene Therapy in a Canine Model of Severe Combined Immunodeficiency by Burtner, Christopher R, Humbert, Olivier, O’Donnell, Patricia, Hubbard, Nicholas, Humphrys, Daniel, Adair, Jennifer E, Trobridge, Grant D, Torgerson, Troy R, Scharenberg, Andrew M, Rawlings, David, Felsburg, Peter J, Kiem, Hans-Peter

“…In vivo gene therapy has several benefits over ex vivo hematopoietic stem cell gene therapy, including the correction of progenitor cells in their native…”
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441. Direct Comparison of EF1α and PGK Promoters Reveals Superior Performance of the PGK Promoter for Expression of the Common Gamma Chain in a Canine Model of In Vivo Foamy Virus Gene Therapy for Severe Combined Immunodeficiency by Burtner, Christopher R., Olivier, Humbert, O'Donnell, Patricia, Hubbard, Nicholas, Humphrys, Daniel, Adair, Jennifer E., Trobridge, Grant D., Torgerson, Troy R., Scharenberg, Andrew M., Rawlings, David J., Felsburg, Peter J., Kiem, Hans-Peter

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Naturally Occurring IgM Anti-Leukocyte Autoantibodies (IgM-ALA) Inhibit T Cell Activation and Chemotaxis by Lobo, Peter I, Schlegel, Kailo H, Spencer, Clinton E, Okusa, Mark D, Chisholm, Christopher, Mchedlishvili, Nino, Park, Andrew, Christ, Constance, Burtner, Christopher

“…The physiological relevance of naturally occurring IgM-ALA remains to be elucidated. These autoantibodies are present from birth and increase in diverse…”
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