Search Results - "Burt Nabors, L."

Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma by BATCHELOR, Tracy T, MULHOLLAND, Paul, DEGROOT, John, GATTAMANENI, Rao, CHER, Lawrence, ROSENTHAL, Mark, PAYER, Franz, JÜRGENSMEIER, Juliane M, JAIN, Rakesh K, GREGORY SORENSEN, A, XU, John, QI LIU, NEYNS, Bart, VAN DEN BENT, Martin, BURT NABORS, L, CAMPONE, Mario, WICK, Antje, MASON, Warren, MIKKELSEN, Tom, PHUPHANICH, Surasak, ASHBY, Lynn S

“…A randomized, phase III, placebo-controlled, partially blinded clinical trial (REGAL [Recent in in Glioblastoma Alone and With Lomustine]) was conducted to…”
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MGMT Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide: A Pooled Analysis of Four Clinical Trials by Hegi, Monika E, Genbrugge, Els, Gorlia, Thierry, Stupp, Roger, Gilbert, Mark R, Chinot, Olivier L, Nabors, L Burt, Jones, Greg, Van Criekinge, Wim, Straub, Josef, Weller, Michael

“…The methylation status of the O -methylguanine DNA methyltransferase ( ) gene promoter is predictive for benefit from temozolomide in glioblastoma (GBM). A…”
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Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma by Happold, Caroline, Gorlia, Thierry, Chinot, Olivier, Gilbert, Mark R, Nabors, L Burt, Wick, Wolfgang, Pugh, Stephanie L, Hegi, Monika, Cloughesy, Timothy, Roth, Patrick, Reardon, David A, Perry, James R, Mehta, Minesh P, Stupp, Roger, Weller, Michael

“…Symptomatic epilepsy is a common complication of glioblastoma and requires pharmacotherapy. Several uncontrolled retrospective case series and a post hoc…”
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Is more better? The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma: a secondary analysis of EORTC and NRG Oncology/RTOG by Blumenthal, Deborah T, Gorlia, Thierry, Gilbert, Mark R, Kim, Michelle M, Burt Nabors, L, Mason, Warren P, Hegi, Monika E, Zhang, Peixin, Golfinopoulos, Vassilis, Perry, James R, Hyun Nam, Do, Erridge, Sara C, Corn, Benjamin W, Mirimanoff, René O, Brown, Paul D, Baumert, Brigitta G, Mehta, Minesh P, van den Bent, Martin J, Reardon, David A, Weller, Michael, Stupp, Roger

“…Radiation with concurrent and adjuvant (6 cycles) temozolomide (TMZ) is the established standard of postsurgical care for newly diagnosed glioblastoma (GBM)…”
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RNA regulation of inflammatory responses in glia and its potential as a therapeutic target in central nervous system disorders by Guha, Abhishek, Husain, Mohammed Amir, Si, Ying, Nabors, L. Burt, Filippova, Natalia, Promer, Grace, Smith, Reed, King, Peter H.

“…A major hallmark of neuroinflammation is the activation of microglia and astrocytes with the induction of inflammatory mediators such as IL‐1β, TNF‐α, iNOS,…”
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Implementation and utilization of the molecular tumor board to guide precision medicine by Harada, Shuko, Arend, Rebecca, Dai, Qian, Levesque, Jessica A, Winokur, Thomas S, Guo, Rongjun, Heslin, Martin J, Nabell, Lisle, Nabors, L Burt, Limdi, Nita A, Roth, Kevin A, Partridge, Edward E, Siegal, Gene P, Yang, Eddy S

“…With rapid advances in genomic medicine, the complexity of delivering precision medicine to oncology patients across a university health system demanded the…”
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Activity of a first-in-class oral HIF2-alpha inhibitor, PT2385, in patients with first recurrence of glioblastoma by Strowd, Roy, Ellingson, Benjamin, Raymond, Catalina, Yao, Jingwen, Wen, Patrick Y., Ahluwalia, Manmeet, Piotrowski, Anna, Desai, Arati, Clarke, Jennifer L., Lieberman, Frank S., Desideri, Serena, Nabors, L. Burt, Ye, Xiaobu, Grossman, Stuart

“…Introduction Hypoxia inducible factor 2-alpha (HIF2α) mediates cellular responses to hypoxia and is over-expressed in glioblastoma (GBM). PT2385 is an oral…”
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Do statins, ACE inhibitors or sartans improve outcome in primary glioblastoma? by Happold, Caroline, Gorlia, Thierry, Nabors, L. Burt, Erridge, Sara C., Reardon, David A., Hicking, Christine, Picard, Martin, Stupp, Roger, Weller, Michael

“…Glioblastomas are malignant brain tumors with poor prognosis. Lately, data from clinical studies assessing the role of co-medications in different cancer types…”
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Phase I and Correlative Biology Study of Cilengitide in Patients With Recurrent Malignant Glioma by BURT NABORS, L, MIKKELSEN, Tom, DIMITRIOS COLEVAS, A, GROSSMAN, Stuart A, ROSENFELD, Steven S, HOCHBERG, Fred, AKELLA, Narasimha S, FISHER, Joy D, CLOUD, Gretchen A, YU ZHANG, CARSON, Kathryn, WITTEMER, Sabine M

“…This multi-institutional phase I trial was designed to determine the maximum-tolerated dose (MTD) of cilengitide (EMD 121974) and to evaluate the use of…”
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Letter: When Less is More: Dexamethasone Dosing for Brain Tumors by Lim-Fat, Mary Jane, Bi, Wenya Linda, Lo, Janet, Lee, Eudocia Quant, Ahluwalia, Manmeet S, Batchelor, Tracy T, Chang, Susan M, Chiocca, Antonio E, Chukwueke, Ugonma, Cloughesy, Timothy F, Colman, Howard, Deangelis, Lisa M, Galanis, Evanthia, Gilbert, Mark R, De Groot, John F, Lassman, Andrew B, Liau, Linda M, Mason, Warren, McFaline-Figueroa, Ricardo J, Mehta, Minesh P, Mellinghoff, Ingo K, Nabors, Burt L, Nayak, Lakshmi, Reardon, David A, Wen, Patrick Y

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Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme by REARDON, David A, FINK, Karen L, SCHIFF, David, SHAPIRO, William R, BURDETTE-RADOUX, Susan, DROPCHO, Edward J, WITTEMER, Sabine M, NIPPGEN, Johannes, PICARD, Martin, BURTNABORS, L, MIKKELSEN, Tom, CLOUGHESY, Timothy F, O'NEILL, Alison, PLOTKIN, Scott, GLANTZ, Michael, RAVIN, Paula, RAIZER, Jeffrey J, RICH, Keith M

“…Cilengitide, an inhibitor of alphavbeta3 and alphavbeta5 integrin receptors, demonstrated minimal toxicity and durable activity across a wide range of doses…”
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Mapping uncharted territory: a gene expression signature for precision glioblastoma therapeutics by Skinner, Kasey R, Nabors, L Burt, Miller, C Ryan

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“It's Not Just the Seizures”: Brain Tumor Caregivers’ Experiences and Educational Needs in Out-of-Hospital Seizure Management by Ejem, Deborah, Stockdill, Macy, Edwards, Rebecca, Dionne-Odom, J. Nicholas, Taylor, Richard, Baehr, Walter, Nabors, L. Burt, Bakitas, Marie, Warren, Paula

“…Objective: Family caregivers (FCGs) of persons with primary brain tumors (PBTs) report high levels of distress related to concerns about out-of-hospital…”
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Baseline requirements for novel agents being considered for phase II/III brain cancer efficacy trials: conclusions from the Adult Brain Tumor Consortium’s first workshop on CNS drug delivery by Grossman, Stuart A, Romo, Carlos G, Rudek, Michelle A, Supko, Jeffrey, Fisher, Joy, Nabors, L Burt, Wen, Patrick Y, Peereboom, David M, Ellingson, Benjamin M, Elmquist, William, Barker, Fred G, Kamson, David, Sarkaria, Jann N, Timmer, William, Bindra, Ranjit S, Ye, Xiaobu

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The RNA-binding protein HuR promotes glioma growth and treatment resistance by Filippova, Natalia, Yang, Xiuhua, Wang, Yimin, Gillespie, G Yancey, Langford, Cathy, King, Peter H, Wheeler, Crystal, Nabors, L Burt

“…Posttranscriptional regulation is a critical control point for the expression of genes that promote or retard tumor growth. We previously found that the…”
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Phase II Study of Iniparib with Concurrent Chemoradiation in Patients with Newly Diagnosed Glioblastoma by Blakeley, Jaishri O, Grossman, Stuart A, Chi, Andrew S, Mikkelsen, Tom, Rosenfeld, Myrna R, Ahluwalia, Manmeet S, Nabors, L Burt, Eichler, April, Ribas, Ignacio Garcia, Desideri, Serena, Ye, Xiaobu

“…Iniparib is a purported prodrug causing cell death through intracellular conversion to nitro radical ions. We assessed the efficacy and safety of iniparib with…”
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Mitochondrial DNA sequence variation and risk of meningioma by Samanic, Claudine M., Teer, Jamie K., Thompson, Zachary J., Creed, Jordan H., Mokhtari, Sepideh, Fridley, Brooke L., Nabors, L. Burt, Williams, Sion L., Egan, Kathleen M.

“…Background Risk factors for meningioma include female gender, African American race, high body mass index (BMI), and exposure to ionizing radiation. Although…”
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Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics by Ostrom, Quinn T., Egan, Kathleen M., Nabors, L. Burt, Gerke, Travis, Thompson, Reid C., Olson, Jeffrey J., LaRocca, Renato, Chowdhary, Sajeel, Eckel‐Passow, Jeanette E., Armstrong, Georgina, Wiencke, John K., Bernstein, Jonine L., Claus, Elizabeth B., Il'yasova, Dora, Johansen, Christoffer, Lachance, Daniel H., Lai, Rose K., Merrell, Ryan T., Olson, Sara H., Sadetzki, Siegal, Schildkraut, Joellen M., Shete, Sanjay, Houlston, Richard S., Jenkins, Robert B., Wrensch, Margaret R., Melin, Beatrice, Amos, Christopher I., Huse, Jason T., Barnholtz‐Sloan, Jill S., Bondy, Melissa L.

“…Glioma incidence is highest in non‐Hispanic Whites, and to date, glioma genome‐wide association studies (GWAS) to date have only included European ancestry…”
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Mitochondrial DNA sequence variation and risk of glioma by Samanic, Claudine M., Teer, Jamie K., Thompson, Zachary J., Creed, Jordan H., Fridley, Brooke L., Burt Nabors, L., Williams, Sion L., Egan, Kathleen M.

“…•The mitochondrial genome (mtDNA) is polymorphic in human populations.•Inherited variants in mtDNA may play a role in cancer risk and progression.•Array-based…”
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Phase I Single-Dose Study of Intracavitary-Administered Iodine-131-TM-601 in Adults With Recurrent High-Grade Glioma by Mamelak, Adam N, Rosenfeld, Steven, Bucholz, Richard, Raubitschek, Andrew, Nabors, L Burt, Fiveash, John B, Shen, Sui, Khazaeli, M B, Colcher, David, Liu, An, Osman, Medhat, Guthrie, Bart, Schade-Bijur, Susan, Hablitz, Diana M, Alvarez, Vernon L, Gonda, Matthew A

“…TM-601 binds to malignant brain tumor cells with high affinity and does not seem to bind to normal brain tissue. Preclinical studies suggest that iodine-131…”
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