Search Results - "Burster, Timo"

Occurrence of a novel cleavage site for cathepsin G adjacent to the polybasic sequence within the proteolytically sensitive activation loop of the SARS-CoV-2 Omicron variant: The amino acid substitution N679K and P681H of the spike protein by Mustafa, Zhadyra, Kalbacher, Hubert, Burster, Timo

“…The serine proteases neutrophil elastase (NE), proteinase 3 (PR3), cathepsin G (CatG), and neutrophil serine protease 4 (NSP4) are secreted by activated…”
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Processing and regulation mechanisms within antigen presenting cells: a possibility for therapeutic modulation by Burster, Timo

“…Processing of antigens within antigen presenting cells (APCs) is necessary for an immune response. Two pathways exist to present antigens to T cells: the major…”
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Variation of Proteolytic Cleavage Sites towards the N-Terminal End of the S2 Subunit of the Novel SARS-CoV-2 Omicron Sublineage BA.2.12.1 by Schilling, Nadine Anna, Kalbacher, Hubert, Burster, Timo

“…The prevalence of novel SARS-CoV-2 variants is also accompanied by an increased turnover rate and additional cleavage sites at the positions necessary for…”
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Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D) by Xu, Pengfei, Ianes, Chiara, Gärtner, Fabian, Liu, Congxing, Burster, Timo, Bakulev, Vasiliy, Rachidi, Najma, Knippschild, Uwe, Bischof, Joachim

“…Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles…”
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The Proteolytic Activity of Neutrophil-Derived Serine Proteases Bound to the Cell Surface Arming Lung Epithelial Cells for Viral Defense by Assylbekova, Akmaral, Allayarova, Maiya, Konysbekova, Moldir, Bekturgan, Amanbek, Makhanova, Aiya, Brown, Samantha, Grzegorzek, Norbert, Kalbacher, Hubert, Kalendar, Ruslan, Burster, Timo

“…The collaboration between cellular proteases and host cells is pivotal in mounting an effective innate immune defense. Of particular interest is the…”
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Neutrophil Elastase and Proteinase 3 Cleavage Sites Are Adjacent to the Polybasic Sequence within the Proteolytic Sensitive Activation Loop of the SARS-CoV‑2 Spike Protein by Mustafa, Zhadyra, Zhanapiya, Anuar, Kalbacher, Hubert, Burster, Timo

“…Serine proteases neutrophil elastase (NE), protease 3 (PR3), cathepsin G (CatG), and neutrophil serine protease 4 (NSP4) are released by activated neutrophils…”
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Cathepsin G and its Dichotomous Role in Modulating Levels of MHC Class I Molecules by Burster, Timo, Knippschild, Uwe, Molnár, Ferdinand, Zhanapiya, Anuar

“…Cathepsin G (CatG) is involved in controlling numerous processes of the innate and adaptive immune system. These features include the proteolytic activity of…”
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Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells by Burster, Timo, Gärtner, Fabian, Bulach, Christiane, Zhanapiya, Anuar, Gihring, Adrian, Knippschild, Uwe

“…Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent…”
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Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation by Burster, Timo, Mustafa, Zhadyra, Myrzakhmetova, Dinara, Zhanapiya, Anuar, Zimecki, Michal

“…During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural…”
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Critical View of Novel Treatment Strategies for Glioblastoma: Failure and Success of Resistance Mechanisms by Glioblastoma Cells by Burster, Timo, Traut, Rebecca, Yermekkyzy, Zhanerke, Mayer, Katja, Westhoff, Mike-Andrew, Bischof, Joachim, Knippschild, Uwe

“…According to the invasive nature of glioblastoma, which is the most common form of malignant brain tumor, the standard care by surgery, chemo- and radiotherapy…”
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Influence of obesity on remodeling of lung tissue and organization of extracellular matrix after blunt thorax trauma by Xu, Pengfei, Gärtner, Fabian, Gihring, Adrian, Liu, Congxing, Burster, Timo, Wabitsch, Martin, Knippschild, Uwe, Paschke, Stephan

“…Abstract Background Previously, it has been shown that obesity is a risk factor for recovery, regeneration, and tissue repair after blunt trauma and can affect…”
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Camostat Does Not Inhibit the Proteolytic Activity of Neutrophil Serine Proteases by Assylbekova, Akmaral, Zhanapiya, Anuar, Grzywa, Renata, Sienczyk, Marcin, Schönbach, Christian, Burster, Timo

“…Coronavirus disease 2019 (COVID-19) can lead to multi-organ failure influenced by comorbidities and age. Binding of the severe acute respiratory syndrome…”
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Activity-Based Probes to Utilize the Proteolytic Activity of Cathepsin G in Biological Samples by Burster, Timo, Gärtner, Fabian, Knippschild, Uwe, Zhanapiya, Anuar

“…Neutrophils, migrating to the site of infection, are able to release serine proteases after being activated. These serine proteases comprise cathepsin G…”
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Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex by Gärtner, Fabian, Gihring, Adrian, Roth, Aileen, Bischof, Joachim, Xu, Pengfei, Elad, Leonard, Wabitsch, Martin, Burster, Timo, Knippschild, Uwe

“…Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The immune response requires tight regulation and can be…”
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Immune phenotypes predict survival in patients with glioblastoma multiforme by Mostafa, Haouraa, Pala, Andrej, Högel, Josef, Hlavac, Michal, Dietrich, Elvira, Westhoff, M Andrew, Nonnenmacher, Lisa, Burster, Timo, Georgieff, Michael, Wirtz, C Rainer, Schneider, E Marion

“…Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The…”
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Application of an Activity-Based Probe to Determine Proteolytic Activity of Cell Surface Cathepsin G by Mass Cytometry Data Acquisition by Gärtner, Fabian, Knippschild, Uwe, Burster, Timo

“…During an immune response, cathepsin G (CatG) takes on the role of adaptive and innate immunity and the outcome depends on the localization of CatG. Soluble,…”
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Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells by Bischof, Joachim, Westhoff, Mike-Andrew, Wagner, Johanna Elisabeth, Halatsch, Marc-Eric, Trentmann, Stephanie, Knippschild, Uwe, Wirtz, Christian Rainer, Burster, Timo

“…One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells,…”
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Cathepsin G: Roles in antigen presentation and beyond by Burster, Timo, Macmillan, Henriette, Hou, Tieying, Boehm, Bernhard O., Mellins, Elizabeth D.

“…Contributions from multiple cathepsins within endosomal antigen processing compartments are necessary to process antigenic proteins into antigenic peptides…”
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Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G by Eipper, Steffen, Steiner, Robin, Lesner, Adam, Sienczyk, Marcin, Palesch, David, Halatsch, Marc-Eric, Zaczynska, Ewa, Heim, Christopher, Hartmann, Marcus D, Zimecki, Michal, Wirtz, Christian Rainer, Burster, Timo

“…Protease-mediated degradation of proteins is critical in a plethora of physiological processes. Neutrophils secrete serine proteases including cathepsin G…”
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Considering the Experimental Use of Temozolomide in Glioblastoma Research by Herbener, Verena J., Burster, Timo, Goreth, Alicia, Pruss, Maximilian, von Bandemer, Hélène, Baisch, Tim, Fitzel, Rahel, Siegelin, Markus D., Karpel-Massler, Georg, Debatin, Klaus-Michael, Westhoff, Mike-Andrew, Strobel, Hannah

“…Temozolomide (TMZ) currently remains the only chemotherapeutic component in the approved treatment scheme for Glioblastoma (GB), the most common primary brain…”
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