Search Results - "Bursten, Stuart L"

Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells by Lavie, Y, Cao, H, Bursten, S L, Giuliano, A E, Cabot, M C

“…Multidrug-resistant (MDR) tumors and cancer cell lines demonstrate a wide variety of biochemical changes. In this study we used drug-sensitive wild-type (wt)…”
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An increase in serum C18 unsaturated free fatty acids as a predictor of the development of acute respiratory distress syndrome by Bursten, Stuart L, Federighi, David A, Parsons, Polly E, Harris, Ward E, Abraham, Edward, Moore, Ernest E. Jr, Moore, Fredrick A, Bianco, James A, Singer, Jack W, Repine, John E

“…OBJECTIVE No means exist for predicting the acute respiratory distress syndrome (ARDS), which complicates sepsis, trauma, and a variety of clinical disorders…”
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Lisofylline causes rapid and prolonged suppression of serum levels of free fatty acids by Bursten, S L, Federighi, D, Wald, J, Meengs, B, Spickler, W, Nudelman, E

“…Lisofylline (LSF), a novel anti-inflammatory compound that modulates stress-associated changes in lipid metabolism, is under development to modify toxicity for…”
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Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs by Guidot, D M, Bursten, S L, Rice, G C, Chaney, R B, Singer, J W, Repine, A J, Hybertson, B M, Repine, J E

“…We determined that lisofylline, a potent inhibitor of oleate- and linoleate-containing phosphatidic acid formation (half-maximal inhibitory concentration = 40…”
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Lisofylline prevents leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally by Hybertson, Brooks M, Bursten, Stuart L, Leff, Jonathan A, Lee, Young M, Jepson, Eric K, Dewitt, Chris R, Zagorski, John, Cho, Hyun G, Repine, John E

“…Brooks M. Hybertson 1 , Stuart L. Bursten 2 , Jonathan A. Leff 1 , Young M. Lee 1 , Eric K. Jepson 1 , Chris R. Dewitt 1 , John Zagorski 3 , Hyun G. Cho 4 ,…”
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Rapid activation of phosphatidate phosphohydrolase in mesangial cells by lipid A by Bursten, Stuart L, Harris, Ward E

“…Knowledge of rapid events in cell signaling initiated by lipid A, the core moiety of bacterial lipopolysaccharide, is limited. In the present study we have…”
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The 31-kDa Precursor of Interleukin 1α is Myristoylated on Specific Lysines within the 16-kDa N-Terminal Propiece by Stevenson, Frazier T., Bursten, Stuart L., Fanton, Christie, Locksley, Richard M., Lovett, David H.

“…The cytokine interleukin 1α (IL-1α) is a critical mediator of the immune and inflammatory responses. A unique determinant of its activity as compared with…”
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Myristyl acylation of the tumor necrosis factor α precursor on specific lysine residues by STEVENSON, F. T, BURSTEN, S. L, LOCKSLEY, R. M, LOVETT, D. H

“…NH2-terminal glycine myristyl acylation is a cotranslational modification that affects both protein localization and function. However, several proteins that…”
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Lisofylline, an inhibitor of unsaturated phosphatidic acid generation, ameliorates interleukin-1 beta-induced dysfunction in cultured rat islets by Bleich, D, Chen, S, Bursten, S L, Nadler, J L

“…Interleukin-1 beta (IL-1 beta) causes rat islet cell dysfunction through mechanisms that involve inducible nitric oxide synthase (iNOS). However, IL-1 beta…”
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Lisofylline, a Modulator of Fatty Acid Metabolism, Increases Peripheral Insulin Sensitivity by BALON, THOMAS W, JASMAN, ARNIE P, BURSTEN, STUART L, NADLER, JERRY L

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Interleukin-1 rapidly stimulates lysophosphatidate acyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells by Bursten, S.L., Harris, W.E., Bomsztyk, K., Lovett, D.

“…Phosphatidic acid (PA) is a cytokine in a variety of cell types, and an intermediary in cell activation. It is produced from membrane phospholipids by either…”
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Human mesangial cells are resistant to productive infection by multiple strains of human immunodeficiency virus types 1 and 2 by Alpers, C E, McClure, J, Bursten, S L

“…Human immunodeficiency virus-associated nephropathy (HIVAN) is a recognized clinical entity of unknown pathogenesis. A role for viral infection of renal cells…”
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The 31-kDa precursor of interleukin 1(alpha) is myristoylated on specific lysines within the 16-kDa N-terminal propiece by Stevenson, Frazier T, Bursten, Stuart L, Fanton, Christie, Locksley, Richard M, Lovett, David H

“…Results of a study show that acylation of the interleukin-1alpha precursor by a previously unrecognized lysyl epsilon-amino N-myristoyltransferase activity may…”
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Mesangial cell activation by bacterial endotoxin. Induction of rapid cytoskeletal reorganization and gene expression by Bursten, SL, Stevenson, F, Torrano, F, Lovett, DH

“…Cultured glomerular mesangial cells (MC) respond to low concentrations of bacterial endotoxin (ET) by secreting prostaglandins and interleukin-1. To evaluate…”
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Generation of phosphatidic acid and diacylglycerols following ligation of surface immunoglobulin in human B lymphocytes: potential role in PKC activation by Valentine, M A, Bursten, S L, Harris, W E, Draves, K E, Pollok, B A, Ostrowski, J, Bomsztyk, K, Clark, E A

“…We have examined signal transduction via membrane IgM (mIgM) in resting and cycling human B cells. Crosslinking mIgM on all of the cell types studied…”
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Oral nifedipine for the treatment of patients with severe hypertension by Davidson, R C, Bursten, S L, Keeley, P A, Kenny, M A, Stewart, D K

“…Ten mg of nifedipine was administered to 19 patients with severe hypertension (mean blood pressure 187 +/- 17/122 +/- 12 mm Hg) without intensive care…”
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