Search Results - "Burrows, N"

The open access malaria box: a drug discovery catalyst for neglected diseases by Spangenberg, Thomas, Burrows, Jeremy N, Kowalczyk, Paul, McDonald, Simon, Wells, Timothy N C, Willis, Paul

“…Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the…”
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Hit and lead criteria in drug discovery for infectious diseases of the developing world by Katsuno, Kei, Burrows, Jeremy N., Duncan, Ken, van Huijsduijnen, Rob Hooft, Kaneko, Takushi, Kita, Kiyoshi, Mowbray, Charles E., Schmatz, Dennis, Warner, Peter, Slingsby, B. T.

“…The quality of the chemical starting points for small-molecule drug discovery is a key factor in improving the likelihood of clinical success. In this article,…”
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The state of the art in anti-malarial drug discovery and development by Burrows, Jeremy N, Chibale, Kelly, Wells, Timothy N C

“…Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet, unfortunately, apart from artemisinin combination therapies there…”
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2SXPS: An Improved and Expanded Swift X-Ray Telescope Point-source Catalog by Evans, P. A., Page, Kim, Osborne, J. P., Beardmore, A. P., Willingale, R., Burrows, D. N., Kennea, J A, Perri, M., Capalbi, M., Tagliaferri, G., Cenko, S. B.

“…We present the 2SXPS (Swift-XRT Point Source) catalog, containing 206,335 point sources detected by the Swift X-ray Telescope (XRT) in the 0.3–10 keV energy…”
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CHANDRA OBSERVES THE END OF AN ERA IN SN 1987A by Frank, Kari A., Zhekov, Svetozar A., Park, Sangwook, McCray, Richard, Dwek, Eli, Burrows, David N.

“…ABSTRACT Updated imaging and photometric results from Chandra observations of SN 1987A, covering the last 16 years, are presented. We find that the 0.5-2 keV…”
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Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials by Duffey, Maëlle, Blasco, Benjamin, Burrows, Jeremy N., Wells, Timothy N.C., Fidock, David A., Leroy, Didier

“…Strategies to counteract or prevent emerging drug resistance are crucial for the design of next-generation antimalarials. In the past, resistant parasites were…”
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New developments in anti-malarial target candidate and product profiles by Burrows, Jeremy N, Duparc, Stephan, Gutteridge, Winston E, Hooft van Huijsduijnen, Rob, Kaszubska, Wiweka, Macintyre, Fiona, Mazzuri, Sébastien, Möhrle, Jörg J, Wells, Timothy N C

“…A decade of discovery and development of new anti-malarial medicines has led to a renewed focus on malaria elimination and eradication. Changes in the way new…”
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Swift Spectra of AT2018cow: A White Dwarf Tidal Disruption Event? by Kuin, N Paul M, Wu, Kinwah, Oates, Samantha, Lien, Amy, Emery, Sam, Kennea, Jamie A., Pasquale, Massimiliano de, Brown, Peter J., Tohuvavohu, Aaron, Breeveld, Alice, Burrows, David N., Cenko, S Bradley, Campana, Sergio, Levan, Andrew, Markwardt, Craig, Osborne, Julian P, Page, Mat J, Page, Kim L, Sbarufatti, Boris, Siegel, Michael, Troja, Eleonora

“…The bright transient AT2018cow has been unlike any other known type of transient. Its high brightness, rapid rise and decay, and initially nearly featureless…”
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Linking fire ecology and fire management in south-west Australian forest landscapes by Burrows, N.D.

“…South-west Australia is a region of remarkable biological diversity, predominantly shaped by diversity of climate and geomorphology. Fire has also played an…”
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Analysis of XMM-Newton Observations of Supernova Remnant W49B and Clues to the Progenitor by Siegel, Jared, Dwarkadas, Vikram V., Frank, Kari A., Burrows, David N.

“…W49B is a supernova remnant (SNR) discovered over 60 yr ago in early radio surveys. It has since been observed over the entire wavelength range, with the X-ray…”
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Dermoscopy for melanoma detection and triage in primary care: a systematic review by Jones, OT, Jurascheck, LC, van Melle, MA, Hickman, S, Burrows, NP, Hall, PN, Emery, J, Walter, FM

“…ObjectiveMost skin lesions first present in primary care, where distinguishing rare melanomas from benign lesions can be challenging. Dermoscopy improves…”
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Physical Processes Shaping Gamma-Ray Burst X-Ray Afterglow Light Curves: Theoretical Implications from the Swift X-Ray Telescope Observations by Zhang, Bing, Fan, Y. Z, Dyks, Jaroslaw, Kobayashi, Shiho, Mészáros, Peter, Burrows, David N, Nousek, John A, Gehrels, Neil

“…With the successful launch of the Swift Gamma-Ray Burst Explorer, a rich trove of early X-ray afterglow data has been collected by its onboard X-Ray Telescope…”
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Relativistic jet activity from the tidal disruption of a star by a massive black hole by Burrows, D. N., Kennea, J. A., Ghisellini, G., Mangano, V., Zhang, B., Page, K. L., Eracleous, M., Romano, P., Sakamoto, T., Falcone, A. D., Osborne, J. P., Campana, S., Beardmore, A. P., Breeveld, A. A., Chester, M. M., Corbet, R., Covino, S., Cummings, J. R., D'Avanzo, P., D'Elia, V., Esposito, P., Evans, P. A., Fugazza, D., Gelbord, J. M., Hiroi, K., Holland, S. T., Huang, K. Y., Im, M., Israel, G., Jeon, Y., Jeon, Y.-B., Jun, H. D., Kawai, N., Kim, J. H., Krimm, H. A., Marshall, F. E., P. Mészáros, Negoro, H., Omodei, N., Park, W.-K., Perkins, J. S., Sugizaki, M., Sung, H.-I., Tagliaferri, G., Troja, E., Ueda, Y., Urata, Y., Usui, R., Antonelli, L. A., Barthelmy, S. D., Cusumano, G., Giommi, P., Melandri, A., Perri, M., Racusin, J. L., Sbarufatti, B., Siegel, M. H., Gehrels, N.

“…Birth of a black-hole relativistic jet Two groups report observations of the X-ray source Swift J164449.3+573451, which was discovered when it triggered the…”
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Spectral Evolution of the X-Ray Remnant of SN 1987A: A High-resolution Chandra HETG Study by Ravi, Aravind P., Park, Sangwook, Zhekov, Svetozar A., Miceli, Marco, Orlando, Salvatore, Frank, Kari A., Burrows, David N.

“…Abstract Based on observations with the Chandra X-ray Observatory, we present the latest spectral evolution of the X-ray remnant of SN 1987A (SNR 1987A). We…”
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Latest Evolution of the X-Ray Remnant of SN 1987A: Beyond the Inner Ring by Ravi, Aravind P., Park, Sangwook, Zhekov, Svetozar A., Orlando, Salvatore, Miceli, Marco, Frank, Kari A., Broos, Patrick S., Burrows, David N.

“…Abstract Based on our Chandra imaging-spectroscopic observations, we present the latest evolution of the X-ray remnant of SN 1987A. Recent changes in the…”
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The unusual X-ray emission of the short Swift GRB 090515: evidence for the formation of a magnetar? by Rowlinson, A., O'Brien, P. T., Tanvir, N. R., Zhang, B., Evans, P. A., Lyons, N., Levan, A. J., Willingale, R., Page, K. L., Onal, O., Burrows, D. N., Beardmore, A. P., Ukwatta, T. N., Berger, E., Hjorth, J., Fruchter, A. S., Tunnicliffe, R. L., Fox, D. B., Cucchiara, A.

“…The majority of short gamma-ray bursts (SGRBs) are thought to originate from the merger of compact binary systems collapsing directly to form a black hole…”
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Branchio‐oculo‐facial syndrome with bilateral postauricular aplasia cutis by Stembridge, N., Burrows, N. P., Holden, S. T.

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Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Deng, Xiaoyi, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, Burrows, Jeremy N, Kaminsky, Werner, Charman, Susan A, Matthews, David, Rathod, Pradipsinh K, Phillips, Margaret A

“…Malaria is one of the most serious global infectious diseases. The pyrimidine biosynthetic enzyme Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH)…”
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Methods and results of an automatic analysis of a complete sample of Swift-XRT observations of GRBs by Evans, P. A., Beardmore, A. P., Page, K. L., Osborne, J. P., O'Brien, P. T., Willingale, R., Starling, R. L. C., Burrows, D. N., Godet, O., Vetere, L., Racusin, J., Goad, M. R., Wiersema, K., Angelini, L., Capalbi, M., Chincarini, G., Gehrels, N., Kennea, J. A., Margutti, R., Morris, D. C., Mountford, C. J., Pagani, C., Perri, M., Romano, P., Tanvir, N.

“…We present a homogeneous X-ray analysis of all 318 gamma-ray bursts detected by the X-ray telescope (XRT) on the Swift satellite up to 2008 July 23; this…”
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THE DEFINITIVE X-RAY LIGHT CURVE OF SWIFT J164449.3+573451 by Mangano, V., Burrows, D. N., Sbarufatti, B., Cannizzo, J. K.

“…ABSTRACT On 2011 March 28, the Swift Burst Alert Telescope triggered on an object that had no analog in over six years of Swift operations. Follow-up…”
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