Search Results - "Burrows, James F"

Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer by Sereesongsaeng, Naphannop, McDowell, Sara H, Burrows, James F, Scott, Christopher J, Burden, Roberta E

“…Lysosomal cysteine protease cathepsin V has previously been shown to exhibit elevated expression in breast cancer tissue and be associated with distant…”
Get full text

A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells by Chen, Xiaoling, Zhang, Luyao, Ma, Chengbang, Zhang, Yingqi, Xi, Xinping, Wang, Lei, Zhou, Mei, Burrows, James F, Chen, Tianbao

“…Antimicrobial peptides are a promising resource for developing novel antibiotic and even anticancer drugs. Here, a 28-mer polypeptide, Ranatuerin-2PLx (R2PLx),…”
Get full text

Cathepsin V regulates cell cycle progression and histone stability in the nucleus of breast cancer cells by Sereesongsaeng, Naphannop, Burrows, James F., Scott, Christopher J., Brix, Klaudia, Burden, Roberta E.

“…Introduction: We previously identified that Cathepsin V (CTSV) expression is associated with poor prognosis in ER+ breast cancer, particularly within the…”
Get full text

Deubiquitylating enzymes in receptor endocytosis and trafficking by McCann, Aidan P, Scott, Christopher J, Van Schaeybroeck, Sandra, Burrows, James F

“…In recent times, our knowledge of the roles ubiquitin plays in multiple cellular processes has expanded exponentially, with one example being the role of…”
Get more information

CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation by Stewart, Lorna M., Gerner, Lisa, Rettel, Mandy, Stein, Frank, Burrows, James F., Mills, Ian G., Evergren, Emma

“…Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) regulates cell and whole-body metabolism and supports tumorigenesis. The cellular impacts of…”
Get full text

Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N‑methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles by Abdelghany, Sharif M, Schmid, Daniela, Deacon, Jill, Jaworski, Jakub, Fay, Francois, McLaughlin, Kirsty M, Gormley, Julie A, Burrows, James F, Longley, Daniel B, Donnelly, Ryan F, Scott, Christopher J

“…meso-Tetra­(N-methyl-4-pyridyl) porphine tetra tosylate (TMP) is a photosensitizer that can be used in photodynamic therapy (PDT) to induce cell death through…”
Get full text

An Effective Modification Strategy to Build Multifunctional Peptides Based on a Trypsin Inhibitory Peptide of the Kunitz Family by Wang, Ying, Shi, Daning, Zou, Wanchen, Jiang, Yangyang, Wang, Tao, Chen, Xiaoling, Ma, Chengbang, Li, Wei, Chen, Tianbao, Burrows, James F, Wang, Lei, Zhou, Mei

“…Peptides with antimicrobial activity or protease inhibitory activity are potential candidates to supplement traditional antibiotics or cancer chemotherapies…”
Get full text

Regulation of cellular responses by deubiquitinating enzymes: an update by Burrows, James F, Johnston, James A

“…The conjugation of ubiquitin as either a monomer or as a chain has long been known to regulate the stability, localisation, trafficking and/or function of many…”
Get full text

Respiratory Syncytial Virus NS1 Protein Degrades STAT2 by Using the Elongin-Cullin E3 Ligase by ELLIOTT, Joanne, LYNCH, Oonagh T, POWER, Ultan F, JOHNSTON, James A, SUESSMUTH, Yvonne, PING QIAN, BOYD, Caroline R, BURROWS, James F, BUICK, Richard, STEVENSON, Nigel J, TOUZELET, Olivier, GADINA, Massimo

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii by Tan, Yining, Chen, Xiaoling, Ma, Chengbang, Xi, Xinping, Wang, Lei, Zhou, Mei, Burrows, James F, Kwok, Hang Fai, Chen, Tianbao

“…The skin secretions of the subfamily Phyllomedusinae have long been known to contain a number of compounds with antimicrobial potential. Herein, a biosynthetic…”
Get full text

Modification and Targeted Design of N-Terminal Truncates Derived from Brevinin with Improved Therapeutic Efficacy by He, Haoyang, Chen, Yuqing, Ye, Zhuming, Chen, Xiaoling, Ma, Chengbang, Zhou, Mei, Xi, Xinping, Burrows, James F, Chen, Tianbao, Wang, Lei

“…Antimicrobial peptides (AMPs) are a class of molecules that play an essential role in innate immune regulation. The Brevinin-1 family are AMPs that show strong…”
Get full text

Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiforme by Jena, Lynn N, Bennie, Lindsey A, McErlean, Emma M, Pentlavalli, Sreekanth, Glass, Kim, Burrows, James F, Kett, Vicky L, Buckley, Niamh E, Coulter, Jonathan A, Dunne, Nicholas J, McCarthy, Helen O

“…Glioblastoma multiforme (GBM) is an incurable aggressive brain cancer in which current treatment strategies have demonstrated limited survival benefit. In…”
Get full text

A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities by Li, Miaoran, Xi, Xinping, Ma, Chengbang, Chen, Xiaoling, Zhou, Mei, Burrows, James F, Chen, Tianbao, Wang, Lei

“…A novel dermaseptin peptide, dermaseptin-PT9 (DPT9), was isolated and identified from by the combination of molecular cloning and LC-MS analysis. Chemically…”
Get full text

Physician Engagement in the Transformation of the Pediatric Patient Experience by Rosen, Paul, MD, MPH, MMM, Burrows, James F., MBA, Greenspan, Jay S., MD, MBA

Get full text

Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISb by Liu, Siyan, Lin, Yaxian, Liu, Jiachen, Chen, Xiaoling, Ma, Chengbang, Xi, Xinping, Zhou, Mei, Chen, Tianbao, Burrows, James F, Wang, Lei

“…Antimicrobial peptides (AMPs) are considered as promising antimicrobial agents due to their potent bioactivity. Palustrin-2 peptides were previously found to…”
Get full text

Factors Influencing Patient Experience in Pediatric Neurology by Singh, Suprit C., BS, Sheth, Raj D., MD, Burrows, James F., MBA, Rosen, Paul, MD, MPH, MMM

“…Abstract Introduction Hospitals have begun to shift toward patient-centered care because of the pay-for-performance system that was established by the Patient…”
Get full text

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells by McCann, Aidan P, Smyth, Peter, Cogo, Francesco, McDaid, William J, Jiang, Lai, Lin, Jia, Evergren, Emma, Burden, Roberta E, Van Schaeybroeck, Sandra, Scott, Christopher J, Burrows, James F

“…The deubiquitinase USP17 is overexpressed in NSCLC and has been shown to be required for the growth and motility of EGFR wild-type (WT) NSCLC cells. USP17 is…”
Get full text

Brevinin-2GHk from Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity by Chen, Guanzhu, Miao, Yuxi, Ma, Chengbang, Zhou, Mei, Shi, Zhanzhong, Chen, Xiaoling, Burrows, James F, Xi, Xinping, Chen, Tianbao, Wang, Lei

“…Brevinins are an important antimicrobial peptide (AMP) family discovered in the skin secretions of Ranidae frogs. The members demonstrate a typical C-terminal…”
Get full text

Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients by Ying, Yuan, Wang, Hui, Xi, Xinping, Ma, Chengbang, Liu, Yue, Zhou, Mei, Du, Qiang, Burrows, James F, Wei, Minjie, Chen, Tianbao, Wang, Lei

“…Dermaseptins are an antimicrobial peptide family widely identified from the skin secretions of phyllomeudusinae frogs. Here, we identify Dermaseptin-PC…”
Get full text

Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor by Miao, Yuxi, Chen, Guanzhu, Xi, Xinping, Ma, Chengbang, Wang, Lei, Burrows, James F, Duan, Jinao, Zhou, Mei, Chen, Tianbao

“…Anuran amphibian skin secretions are a rich source of peptides, many of which represent novel protease inhibitors and can potentially act as a source for…”
Get full text