Search Results - "Burrows, Jacqueline M."

CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection by Miles, John J, Elhassen, Diah, Borg, Natalie A, Silins, Sharon L, Tynan, Fleur E, Burrows, Jacqueline M, Purcell, Anthony W, Kjer-Nielsen, Lars, Rossjohn, Jamie, Burrows, Scott R, McCluskey, James

“…MHC class I molecules generally present peptides of 8-10 aa long, forming an extended coil in the HLA cleft. Although longer peptides can also bind to class I…”
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CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses by Lineburg, Katie E., Grant, Emma J., Swaminathan, Srividhya, Chatzileontiadou, Demetra S.M., Szeto, Christopher, Sloane, Hannah, Panikkar, Archana, Raju, Jyothy, Crooks, Pauline, Rehan, Sweera, Nguyen, Andrea T., Lekieffre, Lea, Neller, Michelle A., Tong, Zhen Wei Marcus, Jayasinghe, Dhilshan, Chew, Keng Yih, Lobos, Christian A., Halim, Hanim, Burrows, Jacqueline M., Riboldi-Tunnicliffe, Alan, Chen, Weisan, D’Orsogna, Lloyd, Khanna, Rajiv, Short, Kirsty R., Smith, Corey, Gras, Stephanie

“…Efforts are being made worldwide to understand the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for…”
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The impact of HLA‐B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV by Burrows, Jacqueline M., Wynn, Katherine K., Tynan, Fleur E., Archbold, Julia, Miles, John J., Bell, Melissa J., Brennan, Rebekah M., Walker, Susan, McCluskey, James, Rossjohn, Jamie, Khanna, Rajiv, Burrows, Scott R.

“…The factors controlling epitope selection in the T cell response to persistent viruses are not fully understood, and we have examined this issue in the context…”
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Widespread Sequence Variation in Epstein-Barr Virus Nuclear Antigen 1 Influences the Antiviral T Cell Response by Bell, Melissa J., Brennan, Rebekah, Miles, John J., Moss, Denis J., Burrows, Jacqueline M., Burrows, Scott R.

“…Epstein-Barr virus (EBV) nuclear antigen (EBNA) 1 is perhaps the most widely studied EBV protein, because of its critical role in maintaining the EBV episome…”
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Defective T‐cell control of Epstein–Barr virus infection in multiple sclerosis by Pender, Michael P, Csurhes, Peter A, Burrows, Jacqueline M, Burrows, Scott R

“…Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in the pathogenesis of multiple sclerosis (MS). Defective elimination…”
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Contemporaneous fluctuations in T cell responses to persistent herpes virus infections by Crough, Tania, Burrows, Jacqueline M., Fazou, Chrysa, Walker, Susan, Davenport, Miles P., Khanna, Rajiv

“…The classical paradigm for T cell dynamics suggests that the resolution of a primary acute virus infection is followed by the generation of a long‐lived pool…”
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Ex Vivo Analysis of T-Cell Responses to Epstein-Barr Virus-Encoded Oncogene Latent Membrane Protein 1 Reveals Highly Conserved Epitope Sequences in Virus Isolates from Diverse Geographic Regions by Duraiswamy, Jaikumar, Burrows, Jacqueline M, Bharadwaj, Mandvi, Burrows, Scott R, Cooper, Leanne, Pimtanothai, Nattiya, Khanna, Rajiv

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Selection Pressure-Driven Evolution of the Epstein-Barr Virus-Encoded Oncogene LMP1 in Virus Isolates from Southeast Asia by BURROWS, Jacqueline M, BROMHAM, Lindell, MOSS, Denis J, HARYANA, Sofia M, NG, Mun, NICHOLLS, John M, KHANNA, Rajiv, WOOLFIT, Megan, PIGANEAU, Gwenaël, TELLAM, Judy, CONNOLLY, Geoff, WEBB, Natasha, POULSEN, Leith, COOPER, Leanne, BURROWS, Scott R

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HLA peptide length preferences control CD8+ T cell responses by Rist, Melissa J, Theodossis, Alex, Croft, Nathan P, Neller, Michelle A, Welland, Andrew, Chen, Zhenjun, Sullivan, Lucy C, Burrows, Jacqueline M, Miles, John J, Brennan, Rebekah M, Gras, Stephanie, Khanna, Rajiv, Brooks, Andrew G, McCluskey, James, Purcell, Anthony W, Rossjohn, Jamie, Burrows, Scott R

“…Class I HLAs generally present peptides of 8-10 aa in length, although it is unclear whether peptide length preferences are affected by HLA polymorphism. In…”
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T cell epitope clustering in the highly immunogenic BZLF1 antigen of Epstein-Barr virus by Rist, Melissa J, Neller, Michelle A, Burrows, Jacqueline M, Burrows, Scott R

“…Polymorphism in the human leukocyte antigen (HLA) loci ensures that the CD8(+) T cell response to viruses is directed against a diverse range of antigenic…”
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Allelic polymorphism in the T cell receptor and its impact on immune responses by Gras, Stephanie, Chen, Zhenjun, Miles, John J, Liu, Yu Chih, Bell, Melissa J, Sullivan, Lucy C, Kjer-Nielsen, Lars, Brennan, Rebekah M, Burrows, Jacqueline M, Neller, Michelle A, Khanna, Rajiv, Purcell, Anthony W, Brooks, Andrew G, McCluskey, James, Rossjohn, Jamie, Burrows, Scott R

“…In comparison to human leukocyte antigen (HLA) polymorphism, the impact of allelic sequence variation within T cell receptor (TCR) loci is much less…”
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The impact of a large and frequent deletion in the human TCR β locus on antiviral immunity by Brennan, Rebekah M, Petersen, Jan, Neller, Michelle A, Miles, John J, Burrows, Jacqueline M, Smith, Corey, McCluskey, James, Khanna, Rajiv, Rossjohn, Jamie, Burrows, Scott R

“…The TCR plays a critical role in recognizing intracellular pathogens and initiating pathways leading to the destruction of infected cells by the immune system…”
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T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide by McCluskey, James, Rossjohn, Jamie, Tynan, Fleur E, Burrows, Scott R, Buckle, Ashley M, Clements, Craig S, Borg, Natalie A, Miles, John J, Beddoe, Travis, Whisstock, James C, Wilce, Matthew C, Silins, Sharon L, Burrows, Jacqueline M, Kjer-Nielsen, Lars, Kostenko, Lyudmila, Purcell, Anthony W

“…Unusually long major histocompatibility complex (MHC) class I-restricted epitopes are important in immunity, but their 'bulged' conformation represents a…”
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T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B18:01+ Cells by Rist, Melissa J, Hibbert, Kelly M, Croft, Nathan P, Smith, Corey, Neller, Michelle A, Burrows, Jacqueline M, Miles, John J, Purcell, Anthony W, Rossjohn, Jamie, Gras, Stephanie, Burrows, Scott R

“…T cell cross-reactivity underpins the molecular mimicry hypothesis in which microbial peptides sharing structural features with host peptides stimulate T cells…”
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Molecular Imprint of Exposure to Naturally Occurring Genetic Variants of Human Cytomegalovirus on the T cell Repertoire by Smith, Corey, Gras, Stephanie, Brennan, Rebekah M., Bird, Nicola L., Valkenburg, Sophie A., Twist, Kelly-Anne, Burrows, Jacqueline M., Miles, John J., Chambers, Daniel, Bell, Scott, Campbell, Scott, Kedzierska, Katherine, Burrows, Scott R., Rossjohn, Jamie, Khanna, Rajiv

“…Exposure to naturally occurring variants of herpesviruses in clinical settings can have a dramatic impact on anti-viral immunity. Here we have evaluated the…”
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Missense single nucleotide polymorphisms in the human T cell receptor loci control variable gene usage in the T cell repertoire by Brennan, Rebekah M., Burrows, Jacqueline M., Elliott, Thomas, Neller, Michelle A., Gras, Stephanie, Rossjohn, Jamie, Miles, John J., Burrows, Scott R.

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Defective T‐cell control of Epstein–Barr virus infection in multiple sclerosis by Pender, Michael P, Csurhes, Peter A, Burrows, Jacqueline M, Burrows, Scott R

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The peptide length specificity of some HLA class I alleles is very broad and includes peptides of up to 25 amino acids in length by Bell, Melissa J., Burrows, Jacqueline M., Brennan, Rebekah, Miles, John J., Tellam, Judy, McCluskey, James, Rossjohn, Jamie, Khanna, Rajiv, Burrows, Scott R.

“…The major ligands presented by MHC class I molecules after natural antigen processing are peptides of eight to ten residues in length, and it is widely…”
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TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope by Miles, John J, Borg, Natalie A, Brennan, Rebekah M, Tynan, Fleur E, Kjer-Nielsen, Lars, Silins, Sharon L, Bell, Melissa J, Burrows, Jacqueline M, McCluskey, James, Rossjohn, Jamie, Burrows, Scott R

“…The underlying generic properties of alphabeta TCRs that control MHC restriction remain largely unresolved. To investigate MHC restriction, we have examined…”
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The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation by Tynan, Fleur E, Elhassen, Diah, Purcell, Anthony W, Burrows, Jacqueline M, Borg, Natalie A, Miles, John J, Williamson, Nicholas A, Green, Kate J, Tellam, Judy, Kjer-Nielsen, Lars, McCluskey, James, Rossjohn, Jamie, Burrows, Scott R

“…Thousands of potentially antigenic peptides are encoded by an infecting pathogen; however, only a small proportion induce measurable CD8(+) T cell responses…”
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