Search Results - "Burrows, Amy C"

The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma by Venere, Monica, Horbinski, Craig, Crish, James F, Jin, Xun, Vasanji, Amit, Major, Jennifer, Burrows, Amy C, Chang, Cathleen, Prokop, John, Wu, Quilian, Sims, Peter A, Canoll, Peter, Summers, Matthew K, Rosenfeld, Steven S, Rich, Jeremy N

“…The proliferative and invasive nature of malignant cancers drives lethality. In glioblastoma, these two processes are presumed mutually exclusive and hence…”
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Skp1-Cul1-F-box Ubiquitin Ligase (SCFβTrCP)-mediated Destruction of the Ubiquitin-specific Protease USP37 during G2-phase Promotes Mitotic Entry by Burrows, Amy C., Prokop, John, Summers, Matthew K.

“…Ubiquitin-mediated proteolysis is a key regulatory process in cell cycle progression. The Skp1-Cul1-F-box (SCF) and anaphase-promoting complex (APC) ubiquitin…”
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Phosphorylation Regulates the p31Comet-Mitotic Arrest-deficient 2 (Mad2) Interaction to Promote Spindle Assembly Checkpoint (SAC) Activity by Date, Dipali A., Burrows, Amy C., Summers, Matthew K.

“…The spindle assembly checkpoint (SAC) ensures the faithful segregation of the genome during mitosis by ensuring that sister chromosomes form bipolar…”
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Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators by Gromovsky, Anthony D, Schugar, Rebecca C, Brown, Amanda L, Helsley, Robert N, Burrows, Amy C, Ferguson, Daniel, Zhang, Renliang, Sansbury, Brian E, Lee, Richard G, Morton, Richard E, Allende, Daniela S, Parks, John S, Spite, Matthew, Brown, J Mark

“…Human genetic variants near the FADS (fatty acid desaturase) gene cluster ( - ) are strongly associated with cardiometabolic traits including dyslipidemia,…”
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The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance by Warrier, Manya, Shih, Diana M., Burrows, Amy C., Ferguson, Daniel, Gromovsky, Anthony D., Brown, Amanda L., Marshall, Stephanie, McDaniel, Allison, Schugar, Rebecca C., Wang, Zeneng, Sacks, Jessica, Rong, Xin, Vallim, Thomas de Aguiar, Chou, Jeff, Ivanova, Pavlina T., Myers, David S., Brown, H. Alex, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Liu, Xiuli, Parini, Paolo, Tontonoz, Peter, Lusis, Aldon J., Hazen, Stanley L., Temel, Ryan E., Brown, J. Mark

“…Circulating levels of the gut microbe-derived metabolite trimethylamine-N-oxide (TMAO) have recently been linked to cardiovascular disease (CVD) risk. Here, we…”
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The deubiquitinating enzyme USP37 enhances CHK1 activity to promote the cellular response to replication stress by Stromberg, Benjamin R., Singh, Mayank, Torres, Adrian E., Burrows, Amy C., Pal, Debjani, Insinna, Christine, Rhee, Yosup, Dickson, Andrew S., Westlake, Christopher J., Summers, Matthew K.

“…The deubiquitinating enzyme USP37 is known to contribute to timely onset of S phase and progression of mitosis. However, it is not clear if USP37 is required…”
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Metaorganismal choline metabolism shapes olfactory perception by Massey, William J., Kay, Kristen E., Jaramillo, Thomas C., Horak, Anthony J., Cao, Shijie, Osborn, Lucas J., Banerjee, Rakhee, Mrdjen, Marko, Hamoudi, Michael K., Silver, Daniel J., Burrows, Amy C., Brown, Amanda L., Reizes, Ofer, Lathia, Justin D., Wang, Zeneng, Hazen, Stanley L., Brown, J. Mark

“…Microbes living in the intestine can regulate key signaling processes in the central nervous system that directly impact brain health. This gut–brain signaling…”
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Abstract 2742: USP37 promote oncogenesis by stabilizing protein involved in DNA damage repair pathway and provides a novel way to modulate Chk1 activity by singh, mayank, Burrows, Amy C., Dickson, Andrew, Summers, Matthew

“…Abstract Dysregulation of the Ubiquitin proteasome system (UPS), which comprises nearly 1000 different components is associated with many aspects of…”
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The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance by Banerjee, Rakhee, Hohe, Rachel C, Cao, Shijie, Jung, Bryan M, Horak, Anthony J, Ramachandiran, Iyappan, Massey, William J, Varadharajan, Venkateshwari, Zajczenko, Natalie I, Burrows, Amy C, Dutta, Sumita, Goudarzi, Maryam, Mahen, Kala, Carter, Abigail, Helsley, Robert N, Gordon, Scott M, Morton, Richard E, Strauch, Christopher, Willard, Belinda, Gogonea, Camelia Baleanu, Gogonea, Valentin, Pedrelli, Matteo, Parini, Paolo, Brown, J Mark

“…The Aster-C protein (encoded by the gene) is an endoplasmic reticulum (ER) resident protein that has been reported to transport cholesterol from the plasma…”
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Coordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferation by Date, Dipali A, Burrows, Amy C, Venere, Monica, Jackson, Mark W, Summers, Matthew K

“…p31(Comet) is a well-known interacting partner of the spindle assembly checkpoint (SAC) effector molecule Mad2. At the molecular level it is well established…”
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Abstract 496: Ubiquitin specific peptidases 37 promotes constitutive replication fork movement by stabilizing Chk1 via its deubiquitination by Singh, Mayank, Burrows, Amy C., Dickson, Andrew, Komal, Komal, Pal, Debjani, Summers, Matthew K.

“…Abstract Protein deubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction…”
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Abstract B23: The deubiquitinating enzyme USP37 stabilizes Chk1 to promote the cellular response to replication stress by Singh, Mayank, Pal, Debjani, Burrows, Amy C., Messina, Abbey, Dickson, Andrew, Summers, Matthew K.

“…Abstract Ubiquitin-mediated proteolysis is a key regulatory process in cell cycle progression. Recently, we identified mutual antagonism between the…”
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The Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Pro-Inflammatory and Pro-Resolving Lipid Mediators by Gromovsky, Anthony D., Schugar, Rebecca C., Brown, Amanda L., Helsley, Robert N., Burrows, Amy C., Ferguson, Daniel, Zhang, Renliang, Sansbury, Brian E., Lee, Richard G., Morton, Richard E., Allende, Daniela S., Parks, John S., Spite, Matthew, Brown, J. Mark

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Abstract 96: The Role of Flavin Monooxygenase 3 (FMO3) in Dietary Choline- and Cholesterol-Driven Atherosclerosis by Schugar, Rebecca C, Gromovsky, Anthony D, Brown, Amanda L, Burrows, Amy C, Ferguson, Daniel L, Graham, Mark J, Crooke, Rosanne M, Lee, Richard G, Wang, Zeneng, Hazen, Stanley L, Brown, J. Mark

“…Abstract only The gut microbiome represents an important endocrine organ generating nutrient metabolites that promote the pathogenesis of cardiovascular…”
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Coordinated regulation of p31Comet and Mad2 expression is required for cellular proliferation by Date, Dipali, Burrows, Amy, Venere, Monica, Jackson, Mark, Summers, Matthew

“…p31 Comet is a well-known interacting partner of the spindle assembly checkpoint (SAC) effector molecule Mad2. At the molecular level it is well established…”
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